INT49657

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Context Info
Confidence 0.46
First Reported 1993
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 3.00
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pyy) extracellular region (Pyy)
Anatomy Link Frequency
plasma 1
nerve 1
colon 1
sympathetic 1
Pyy (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 3 98.32 Very High Very High Very High
tetrodotoxin 5 98.24 Very High Very High Very High
Cholecystokinin 9 98.04 Very High Very High Very High
lidocaine 2 97.08 Very High Very High Very High
antagonist 4 92.52 High High
Neuropeptide 3 85.12 High High
Spinal cord 4 82.88 Quite High
abdominal pain 1 77.44 Quite High
anesthesia 3 67.68 Quite High
Inflammation 3 60.12 Quite High
Disease Link Frequency Relevance Heat
Necrosis 9 99.24 Very High Very High Very High
Pancreatitis 12 98.72 Very High Very High Very High
Congenital Anomalies 1 91.68 High High
Adenocarcinoma 2 90.60 High High
Cryptosporidiosis 6 90.20 High High
Diarrhoea 4 89.08 High High
Injury 9 85.28 High High
Pressure And Volume Under Development 6 84.88 Quite High
Frailty 4 83.16 Quite High
Constipation 1 79.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Peptide YY (PYY), a known inhibitor of both pancreatic secretion and the release of cholecystokinin (CCK), may play a role in the pathophysiology of acute pancreatitis (AP).
Negative_regulation (inhibitor) of PYY associated with pancreatitis and cholecystokinin
1) Confidence 0.46 Published 1993 Journal Am. J. Surg. Section Abstract Doc Link 7685154 Disease Relevance 0.48 Pain Relevance 0.14
The inhibitory effect of PYY was eliminated with the prostaglandin synthesis inhibitor indomethacin and with the nerve conduction blocker tetrodotoxin.
Negative_regulation (effect) of PYY in nerve associated with tetrodotoxin
2) Confidence 0.37 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353387 Disease Relevance 0.25 Pain Relevance 0.14
Peptide YY (PYY) is a powerful inhibitor of intestinal secretion mediated by cAMP agonists such as vasoactive intestinal peptide and prostaglandin E2.
Negative_regulation (inhibitor) of PYY associated with agonist
3) Confidence 0.36 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353387 Disease Relevance 0.25 Pain Relevance 0.10
We previously documented significant decreases in plasma PYY in sodium taurocholate-induced AP in the anesthetized pig, with exogenous PYY suppressing plasma amylase activity.
Negative_regulation (decreases) of PYY in plasma associated with pancreatitis
4) Confidence 0.34 Published 1993 Journal Am. J. Surg. Section Abstract Doc Link 7685154 Disease Relevance 0.55 Pain Relevance 0.21
In addition, pancreatic histologic findings were significantly improved in those rats receiving PYY (decreased vacuolization and necrosis).
Negative_regulation (decreased) of PYY associated with necrosis
5) Confidence 0.34 Published 1993 Journal Am. J. Surg. Section Abstract Doc Link 7685154 Disease Relevance 0.68 Pain Relevance 0.03
Partial inhibition of PYY responses was observed following BIBP3226 pretreatment of rat colon mucosal preparations in the presence and absence of tetrodotoxin.
Negative_regulation (inhibition) of PYY in colon associated with tetrodotoxin
6) Confidence 0.32 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8880067 Disease Relevance 0.15 Pain Relevance 0.34
The inhibitory effect of peptide YY was suppressed, or strongly and significantly reduced, by tetrodotoxin, hexamethonium, lidocaine, idazoxan and BMY14,802 (51-(4-fluorophenyl)-4-(-4-(5-fluoro-2pyrimidinyl)-1-piperazinyl)- 1-butanol), whereas devazepide and L-NAME (L-omega-N-arginine methyl ester) had no effect.
Negative_regulation (suppressed) of peptide YY associated with tetrodotoxin and lidocaine
7) Confidence 0.17 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9311665 Disease Relevance 0 Pain Relevance 0.24
The inhibitory effect of peptide YY was suppressed, or strongly and significantly reduced, by tetrodotoxin, hexamethonium, lidocaine, idazoxan and BMY14,802 (51-(4-fluorophenyl)-4-(-4-(5-fluoro-2pyrimidinyl)-1-piperazinyl)- 1-butanol), whereas devazepide and L-NAME (L-omega-N-arginine methyl ester) had no effect.
Negative_regulation (effect) of peptide YY associated with tetrodotoxin and lidocaine
8) Confidence 0.17 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9311665 Disease Relevance 0 Pain Relevance 0.24
We hypothesized that abdominal sympathetic pathways provide tonic inhibition of peptide YY and motilin release and that postprandial increases in these gut hormones are mediated through spinal pathways.
Negative_regulation (inhibition) of peptide YY in sympathetic
9) Confidence 0.03 Published 1995 Journal Am J Phys Med Rehabil Section Abstract Doc Link 7576409 Disease Relevance 0.64 Pain Relevance 0.20

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