INT49659

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Context Info
Confidence 0.43
First Reported 1994
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 1.71
Pain Relevance 3.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fosl2) nucleolus (Fosl2) nucleus (Fosl2)
DNA binding (Fosl2) response to stress (Fosl2)
Anatomy Link Frequency
spinal cord 1
brain 1
nucleus 1
PGE2 1
Fosl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nicotine 10 99.62 Very High Very High Very High
withdrawal 7 99.42 Very High Very High Very High
qutenza 2 99.10 Very High Very High Very High
Spinal cord 3 99.04 Very High Very High Very High
Nucleus accumbens 4 98.36 Very High Very High Very High
cerebral cortex 2 95.52 Very High Very High Very High
conotoxin 1 94.56 High High
Morphine 7 94.44 High High
cocaine 2 89.52 High High
Pain 4 84.80 Quite High
Disease Link Frequency Relevance Heat
Stress 10 99.40 Very High Very High Very High
Nociception 2 92.44 High High
Bordatella Infection 2 85.80 High High
Pain 3 84.80 Quite High
Vibrio Infection 2 77.68 Quite High
Injury 1 74.28 Quite High
Disease 1 61.84 Quite High
Substance Withdrawal Syndrome 1 61.12 Quite High
Nervous System Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The time course of the induction of NGFI-A, NGFI-B, fra-2 and TIS11 was similar to that previously observed with c-fos and the members of the jun family.
Positive_regulation (induction) of fra-2
1) Confidence 0.43 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7808222 Disease Relevance 0.41 Pain Relevance 0.13
Capsaicin-induced stress caused a rapid and transient induction of NGFI-A, NGFI-B, fra-2 and TIS11 in the hypothalamic paraventricular nucleus.
Positive_regulation (induction) of fra-2 in nucleus associated with stress and qutenza
2) Confidence 0.31 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7808222 Disease Relevance 0.42 Pain Relevance 0.14
Additionally, repeated administrations of nicotine transiently induced the c-fos and c-jun mRNA levels after the first-third nicotine administration, and the c-fos and c-jun mRNA levels were returned to the basal level after the seventh administration of nicotine. c-Fos, c-Jun and Fra-2 protein levels were persistently increased until the seventh administration.
Positive_regulation (increased) of Fra-2 associated with nicotine
3) Confidence 0.28 Published 2002 Journal Life Sci. Section Abstract Doc Link 12269402 Disease Relevance 0 Pain Relevance 0.50
Withdrawal studies demonstrated robust induction of several known acute Fras, including c-Fos, FosB, Fra-1, Fra-2, and delta FosB, at 6 hr after naltrexone precipitation of withdrawal in the striatum, nucleus accumbens, and several other brain regions.
Positive_regulation (induction) of Fra-2 in brain associated with nucleus accumbens and withdrawal
4) Confidence 0.21 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8609891 Disease Relevance 0.06 Pain Relevance 1.02
The increases of proENK and proDYN mRNA levels induced by KA were well-correlated with the increases of c-Fos, Fra-2, FosB, c-Jun, and JunB protein levels, which were significantly increased 3 h after KA administration and effectively inhibited by administration with melatonin.
Positive_regulation (increases) of Fra-2
5) Confidence 0.18 Published 2000 Journal Hippocampus Section Abstract Doc Link 10902893 Disease Relevance 0 Pain Relevance 0.08
The pre-administration with L-NAME further increased KA-induced c-jun and c-fos mRNA levels in addition to their protein product levels, although the pre-treatment with L-NAME did not affect KA-induced FosB, Fra-2, JunB, and JunD protein levels at 6 h after treatment.
Positive_regulation (induced) of Fra-2
6) Confidence 0.15 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.07
The treatment with CTX, but not PTX, increased c-Fos and Fra-2 protein levels as well as AP-1, CRE, or ENKCRE-2 DNA binding activity, but neither toxin affected Fra-1, c-Jun, JunB, and JunD protein levels.
Positive_regulation (increased) of Fra-2
7) Confidence 0.13 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11295234 Disease Relevance 0.31 Pain Relevance 0.04
In addition to the proENK mRNA level, PGE2 also increased c-Fos (approximately 4.3-fold), Fra-1 ( approximately 3.8 fold), and Fra-2 (approximately 8.2-fold) protein levels at 4 h after drug treatment.
Positive_regulation (increased) of Fra-2 in PGE2
8) Confidence 0.13 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9757037 Disease Relevance 0 Pain Relevance 0.05
The increases of proENK and proDYN mRNA levels induced by KA were well-correlated with the increases of c-Fos, Fra-2, FosB, c-Jun, and JunB protein levels, which were significantly increased 3 h after KA administration and effectively inhibited by administration with melatonin.
Positive_regulation (increased) of Fra-2
9) Confidence 0.12 Published 2000 Journal Hippocampus Section Abstract Doc Link 10902893 Disease Relevance 0 Pain Relevance 0.08
While c-Fos, Fra-2 and JunB were increased in response to either stimuli, only Fra-1, c-Jun and JunD were increased by PMA.
Positive_regulation (increased) of Fra-2
10) Confidence 0.11 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11113530 Disease Relevance 0 Pain Relevance 0.04
Though we have focused on only one IEG, c-fos, and attempted to relate appearance to known functional changes within the spinal cord, there are in fact many more genes known to be upregulated with the same or slower kinetics (e.g.
Positive_regulation (upregulated) of FRA-2 in spinal cord associated with spinal cord
11) Confidence 0.01 Published 1995 Journal Br J Anaesth Section Abstract Doc Link 7577252 Disease Relevance 0.51 Pain Relevance 0.93

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