INT49660

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Context Info
Confidence 0.69
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 54
Total Number 55
Disease Relevance 32.17
Pain Relevance 9.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (EGR1) nucleus (EGR1) intracellular (EGR1)
DNA binding (EGR1) cytoplasm (EGR1)
Anatomy Link Frequency
endothelial cells 4
epithelial cells 4
spinal cord 1
finger 1
apoptotic cell 1
EGR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 298 100.00 Very High Very High Very High
cINOD 109 100.00 Very High Very High Very High
substance P 18 99.54 Very High Very High Very High
Spinal cord 3 99.04 Very High Very High Very High
cytokine 113 98.66 Very High Very High Very High
Inflammatory mediators 5 95.24 Very High Very High Very High
aspirin 29 94.68 High High
agonist 117 94.32 High High
Pain 16 92.80 High High
antagonist 104 92.24 High High
Disease Link Frequency Relevance Heat
Cancer 570 100.00 Very High Very High Very High
INFLAMMATION 343 100.00 Very High Very High Very High
Apoptosis 1105 99.46 Very High Very High Very High
Nicotine Addiction 63 99.36 Very High Very High Very High
Pulmonary Disease 194 99.32 Very High Very High Very High
Shock 11 99.12 Very High Very High Very High
Increased Venous Pressure Under Development 79 98.64 Very High Very High Very High
Leukemia 44 98.04 Very High Very High Very High
Injury 41 98.04 Very High Very High Very High
Lung Cancer 44 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Extending the previous study, EGR-1 induction by sulindac sulfide was observed both in the non-transformed and transformed human intestinal epithelial cell lines.
Positive_regulation (induction) of EGR-1 in epithelial cell
1) Confidence 0.69 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17599376 Disease Relevance 0.71 Pain Relevance 0.35
Previously we reported that sulindac sulfide can suppress tumor cell invasion by inducing EGR-1.
Positive_regulation (inducing) of EGR-1 associated with cancer
2) Confidence 0.69 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17599376 Disease Relevance 0.71 Pain Relevance 0.36
Taken all together, sulindac sulfide activated ERK1/2 MAP kinases which then mediated EGR-1 induction and nuclear translocation, all of which played important roles in the cellular survival from NSAID-mediated cytotoxicity in the human intestinal epithelial cells, implicating the protective roles of EGR-1 in the NSAID-mediated mucosal injuries.
Positive_regulation (induction) of EGR-1 in epithelial cells associated with injury and cinod
3) Confidence 0.69 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17599376 Disease Relevance 0.62 Pain Relevance 0.24
The early growth response factor (Egr-1) is a transcription factor, which is rapidly activated by a variety of extracellular signals or tissue injury and is important for angiogenesis to occur.
Positive_regulation (activated) of Egr-1 associated with injury
4) Confidence 0.68 Published 2001 Journal J. Physiol. Paris Section Abstract Doc Link 11595463 Disease Relevance 0.37 Pain Relevance 0.42
VEGF treatment caused a significant elevation of Egr-1 mRNA (261+/-21%, P<0.001) and protein expression (174+/-15%, P<0.01) vs. vehicle.
Positive_regulation (elevation) of Egr-1
5) Confidence 0.68 Published 2001 Journal J. Physiol. Paris Section Abstract Doc Link 11595463 Disease Relevance 0.27 Pain Relevance 0.38
Since transcriptional activation of egr-1 is responsible for expression of proteins involved in proliferation of endothelial cells essential for angiogenesis, these results provide a new mechanism for NSAIDs' interference with angiogenesis.
Positive_regulation (activation) of egr-1 in endothelial cells associated with cinod
6) Confidence 0.68 Published 2001 Journal J. Physiol. Paris Section Abstract Doc Link 11595463 Disease Relevance 0.12 Pain Relevance 0.20
NSAIDs inhibit the activation of egr-1 gene in microvascular endothelial cells.
Positive_regulation (activation) of egr-1 in endothelial cells associated with cinod
7) Confidence 0.68 Published 2001 Journal J. Physiol. Paris Section Title Doc Link 11595463 Disease Relevance 0.35 Pain Relevance 0.47
Additionally, the transcription factor early growth response-1 (Egr-1) gene was transcriptionally activated and the levels of non-steroidal anti-inflammatory drug (NSAID)-activated gene-1 (NAG-1) protein were elevated in platycodon D-treatedU937 cells.
Positive_regulation (activated) of Egr-1 associated with inflammation and cinod
8) Confidence 0.66 Published 2009 Journal Biomed. Pharmacother. Section Abstract Doc Link 18804340 Disease Relevance 0.95 Pain Relevance 0.18
ATF3 and Egr-1 mRNA and protein and ATF3 promoter activity were induced by these compounds, whereas induction of ATF3 by these compounds was blocked by Egr-1 small interfering RNA.
Positive_regulation (induced) of Egr-1 mRNA
9) Confidence 0.62 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0.21 Pain Relevance 0.07
Moreover, induced EGR-1 ameliorated sulindac sulfide-mediated apoptotic cell death and enhanced the cellular survival.
Positive_regulation (induced) of EGR-1 in apoptotic cell associated with apoptosis and death
10) Confidence 0.60 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17599376 Disease Relevance 0.68 Pain Relevance 0.23
Our findings suggest that NAG-1 expression is up-regulated by isochaihulactone through an ERK-dependent pathway involving the activation of EGR-1.
Positive_regulation (activation) of EGR-1
11) Confidence 0.59 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17715378 Disease Relevance 0.53 Pain Relevance 0.07
Additionally, the transcription factor early growth response-1 (Egr-1) gene was transcriptionally activated and the levels of non-steroidal anti-inflammatory drug (NSAID)-activated gene-1 (NAG-1) protein were elevated in platycodon D-treatedU937 cells.
Positive_regulation (activated) of factor early growth response-1 associated with inflammation and cinod
12) Confidence 0.57 Published 2009 Journal Biomed. Pharmacother. Section Abstract Doc Link 18804340 Disease Relevance 0.96 Pain Relevance 0.18
Up-regulation of early growth response gene 1 (EGR-1) via ERK1/2 signals attenuates sulindac sulfide-mediated cytotoxicity in the human intestinal epithelial cells.
Positive_regulation (Up-regulation) of EGR-1 in epithelial cells
13) Confidence 0.50 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 17599376 Disease Relevance 0.66 Pain Relevance 0.41
Up-regulation of early growth response gene 1 (EGR-1) via ERK1/2 signals attenuates sulindac sulfide-mediated cytotoxicity in the human intestinal epithelial cells.
Positive_regulation (Up-regulation) of early growth response gene 1 in epithelial cells
14) Confidence 0.50 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 17599376 Disease Relevance 0.60 Pain Relevance 0.41
Our results suggest that EGR-1 induction is a unique property of TGZ, but is independent of PPARgamma activation.
Positive_regulation (induction) of EGR-1
15) Confidence 0.50 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14662774 Disease Relevance 0.18 Pain Relevance 0.16
Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growth response gene EGR-1.
Positive_regulation (requires) of EGR-1 associated with cytokine
16) Confidence 0.50 Published 2004 Journal J. Biol. Chem. Section Title Doc Link 14662774 Disease Relevance 0.41 Pain Relevance 0.16
In this report, we show that the expression of the antitumorigenic and/or pro-apoptotic gene NAG-1 (nonsteroidal anti-inflammatory drug-activated gene-1) is induced by TGZ and correlates with EGR-1 induction.
Positive_regulation (induction) of EGR-1 associated with inflammation, cinod and apoptosis
17) Confidence 0.50 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14662774 Disease Relevance 0.43 Pain Relevance 0.20
Though we have focused on only one IEG, c-fos, and attempted to relate appearance to known functional changes within the spinal cord, there are in fact many more genes known to be upregulated with the same or slower kinetics (e.g.
Positive_regulation (upregulated) of NGFI-A in spinal cord associated with spinal cord
18) Confidence 0.49 Published 1995 Journal Br J Anaesth Section Abstract Doc Link 7577252 Disease Relevance 0.51 Pain Relevance 0.93
Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene.
Positive_regulation (involves) of early growth response-1
19) Confidence 0.49 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 16079301 Disease Relevance 0.28 Pain Relevance 0.10
Immediate early genes (IEGs), including the fos, jun, and NGFI-A families, are induced by a wide variety of intracellular signaling pathways.
Positive_regulation (induced) of NGFI-A
20) Confidence 0.49 Published 1993 Journal Crit Rev Neurobiol Section Abstract Doc Link 8221912 Disease Relevance 0.07 Pain Relevance 0.15

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