INT49672

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Context Info
Confidence 0.21
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.07
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1) extracellular space (IGF1) extracellular region (IGF1)
Anatomy Link Frequency
Chondrocytes 2
IGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 54 98.30 Very High Very High Very High
palliative 1 97.00 Very High Very High Very High
Somatostatin 5 94.96 High High
Inflammatory mediators 2 26.96 Quite Low
Inflammation 6 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 54 98.30 Very High Very High Very High
Obesity 104 98.24 Very High Very High Very High
Overweight 13 91.80 High High
Disease 1 76.88 Quite High
Advanced Or Metastatic Breast Cancer 5 75.00 Quite High
INFLAMMATION 7 26.96 Quite Low
Body Weight 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chondrocytes from obese OA patients exhibited an opposite response to the adipokine with a lack of significant effect on IGF-1 expression at 100 ng/ml but a strong up-regulation of IGF-1 at 500 ng/ml of leptin (Figure 2).
Regulation (effect) of Negative_regulation (regulation) of IGF-1 in Chondrocytes associated with obesity and osteoarthritis
1) Confidence 0.21 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.71 Pain Relevance 0.05
Further studies should be undertaken to investigate the effect of higher drug doses, given subcutaneously or by means of continuous infusion, in suppressing GH and IGF-1 serum levels.
Spec (investigate) Regulation (effect) of Negative_regulation (suppressing) of IGF-1
2) Confidence 0.09 Published 1995 Journal Breast Cancer Res. Treat. Section Abstract Doc Link 7579488 Disease Relevance 0.35 Pain Relevance 0.28

General Comments

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