INT49701

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Context Info
Confidence 0.58
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 3.01
Pain Relevance 5.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf) extracellular space (Ngf) aging (Ngf)
extracellular region (Ngf) molecular_function (Ngf)
Anatomy Link Frequency
PSC 2
neurons 2
skin 2
lactotrophs 2
dorsal horn 2
Ngf (Rattus norvegicus)
Ngf - R221W (1)
Pain Link Frequency Relevance Heat
Nerve growth factor 94 100.00 Very High Very High Very High
tetrodotoxin 9 99.84 Very High Very High Very High
Glutamate 21 98.84 Very High Very High Very High
Trk A 5 96.76 Very High Very High Very High
spinal dorsal horn 1 95.80 Very High Very High Very High
Inflammation 31 91.72 High High
pain insensitivity 2 90.64 High High
sodium channel 1 89.12 High High
antagonist 45 87.44 High High
Pain 18 87.28 High High
Disease Link Frequency Relevance Heat
Frailty 2 98.20 Very High Very High Very High
Primary Sclerosing Cholangitis 6 94.88 High High
Cirrhosis 3 93.48 High High
Nociception 6 92.92 High High
Hypersensitivity 1 92.72 High High
INFLAMMATION 32 91.72 High High
Pain 13 90.08 High High
Mycobacterium Infection 9 85.60 High High
Apoptosis 2 81.12 Quite High
Pancreatic Cancer 1 78.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reduction in numbers of sensory fibers observed in the patients is therefore probably due to loss of trophic support as a result of drastically reduced secretion of NGF from the target organs.
Negative_regulation (reduced) of Localization (secretion) of NGF
1) Confidence 0.58 Published 2009 Journal Neurobiol. Dis. Section Abstract Doc Link 19038341 Disease Relevance 0.21 Pain Relevance 0.25
The combination of both treatments reduced NGF release to below the detection limit, suggesting that basal release has constitutive and regulated components, the latter presumably resulting from spontaneous activity of interconnected neurons.
Negative_regulation (reduced) of Localization (release) of NGF in neurons associated with nerve growth factor
2) Confidence 0.56 Published 1995 Journal Eur. J. Neurosci. Section Abstract Doc Link 7582095 Disease Relevance 0 Pain Relevance 0.78
The KCl- and veratridine-initiated NGF release was suppressed by tetrodotoxin; release by glutamate was less sensitive to tetrodotoxin but was sodium-dependent.
Negative_regulation (suppressed) of Localization (release) of NGF associated with tetrodotoxin, glutamate and nerve growth factor
3) Confidence 0.56 Published 1995 Journal Eur. J. Neurosci. Section Abstract Doc Link 7582095 Disease Relevance 0 Pain Relevance 0.88
Keratinocyte trk A expression (which mediates an autocrine role for NGF) was increased in clinically affected and unaffected skin, suggesting a compensatory mechanism secondary to reduced NGF secretion at both sites.
Negative_regulation (reduced) of Localization (secretion) of NGF in skin associated with nerve growth factor and trk a
4) Confidence 0.52 Published 2000 Journal Pain Section Abstract Doc Link 10692623 Disease Relevance 0.99 Pain Relevance 0.98
We also show that the inability of PC12 cells to differentiate is due to a markedly reduced secretion of mature R221W NGF.
Negative_regulation (reduced) of Localization (secretion) of R221W NGF (R221W)
5) Confidence 0.50 Published 2009 Journal Neurobiol. Dis. Section Abstract Doc Link 19038341 Disease Relevance 0.24 Pain Relevance 0.28
Basal NGF release could be reduced by either temperature block (15 degrees C) or tetrodotoxin to approximately 50%.
Negative_regulation (reduced) of Localization (release) of NGF associated with tetrodotoxin and nerve growth factor
6) Confidence 0.41 Published 1995 Journal Eur. J. Neurosci. Section Abstract Doc Link 7582095 Disease Relevance 0 Pain Relevance 0.84
NGF secretion was diminished by the activin-like kinase (ALK)-5 inhibitor SB431542, indicating the predominant role of ALK5 in activating the NGF system in PSC.
Negative_regulation (diminished) of Localization (secretion) of NGF in PSC associated with nerve growth factor and primary sclerosing cholangitis
7) Confidence 0.40 Published 2009 Journal Growth Factors Section Abstract Doc Link 19639490 Disease Relevance 1.01 Pain Relevance 0.72
Immunoneutralisation of secreted NGF completely prevented the generation of lactotrophs (391).
Negative_regulation (prevented) of Localization (secreted) of NGF in lactotrophs associated with nerve growth factor
8) Confidence 0.24 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.33
Blockade of NGF transport is followed by transganglionic degenerative atrophy in the segmentally related, ipsilateral superficial spinal dorsal horn, characterized by depletion of the marker enzymes of nociception, fluoride resistant acid phosphatase (FRAP) and thiamine monophosphatase (TMP) from the Rolando substance and by decrease of the pain-related neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) from lamina I-II-III.
Negative_regulation (Blockade) of Localization (transport) of NGF in dorsal horn associated with nociception, pain, spinal dorsal horn, calcitonin gene-related peptide, nerve growth factor, neuropeptide, frailty and substance p
9) Confidence 0.15 Published 2010 Journal Ideggyogy Sz Section Abstract Doc Link 20648783 Disease Relevance 0.56 Pain Relevance 0.70

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