INT49702

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 1.77
Pain Relevance 3.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Grip2) plasma membrane (Grip2) cytoskeleton (Grip2)
cytoplasm (Grip2)
Anatomy Link Frequency
soma 3
nerve cells 2
synapses 2
proximal 1
Grip2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 14 99.80 Very High Very High Very High
noradrenaline 5 99.52 Very High Very High Very High
nMDA receptor 17 99.34 Very High Very High Very High
Inflammation 13 99.22 Very High Very High Very High
Pain 3 98.24 Very High Very High Very High
Eae 1 98.20 Very High Very High Very High
Dopamine 108 96.84 Very High Very High Very High
Glutamate 29 96.68 Very High Very High Very High
antagonist 29 95.08 Very High Very High Very High
Spinal cord 18 94.48 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 9 99.22 Very High Very High Very High
Pain 3 98.24 Very High Very High Very High
Hyperalgesia 1 92.40 High High
Heart Rate Under Development 37 90.04 High High
Depression 28 86.96 High High
Nociception 2 75.00 Quite High
Peripheral Arterial Disease 1 61.56 Quite High
Aids-related Complex 1 53.76 Quite High
Injury 1 47.44 Quite Low
Headache 1 43.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The novel finding of this study is that carrageenan-induced inflammation, in the presence of cyclothiazide, an inhibitor of AMPA receptor desensitization, produces a sustained facilitation of the AMPA-mediated membrane current and rises in [Ca2+]i in both the soma and proximal dendrites of SG neurons recorded on the injected side 3 h after the induction of inflammation.
Negative_regulation (inhibitor) of Negative_regulation (desensitization) of AMPA in soma associated with substantia gelatinosa and inflammation
1) Confidence 0.43 Published 2004 Journal Cell Calcium Section Abstract Doc Link 15003855 Disease Relevance 0.35 Pain Relevance 0.48
The present results suggest that pharmacological block of AMPA receptor desensitization led to strong excitation of motoneurons and indicate a physiological role of desensitization in protecting these nerve cells from overactivity.
Negative_regulation (block) of Negative_regulation (desensitization) of AMPA receptor in nerve cells
2) Confidence 0.42 Published 1995 Journal Eur. J. Neurosci. Section Abstract Doc Link 7582096 Disease Relevance 0.09 Pain Relevance 0.19
The present findings point out a selective down-regulation of AMPA receptor subunits in the transduction of trigeminal pain.
Negative_regulation (down) of Negative_regulation (regulation) of AMPA receptor associated with pain
3) Confidence 0.36 Published 1999 Journal Neuroscience Section Abstract Doc Link 10188946 Disease Relevance 0.53 Pain Relevance 0.52
AMPA down-regulation reduced the agonist stimulated increase in cortical O2 consumption.
Negative_regulation (reduced) of Negative_regulation (down-regulation) of AMPA associated with agonist
4) Confidence 0.23 Published 2004 Journal Neurochem. Res. Section Abstract Doc Link 15202775 Disease Relevance 0 Pain Relevance 0.29
The novel finding of this study is that carrageenan-induced inflammation, in the presence of cyclothiazide, an inhibitor of AMPA receptor desensitization, produces a sustained facilitation of the AMPA-mediated membrane current and rises in [Ca2+]i in both the soma and proximal dendrites of SG neurons recorded on the injected side 3 h after the induction of inflammation.
Negative_regulation (inhibitor) of in proximal Negative_regulation (desensitization) of AMPA in soma associated with substantia gelatinosa and inflammation
5) Confidence 0.15 Published 2004 Journal Cell Calcium Section Abstract Doc Link 15003855 Disease Relevance 0.35 Pain Relevance 0.48
Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) also evoked release of [3H]NA, which was enhanced by blocking AMPA receptor desensitization with cyclothiazide.
Negative_regulation (blocking) of Negative_regulation (desensitization) of AMPA associated with noradrenaline
6) Confidence 0.10 Published 1998 Journal Neurochem. Res. Section Abstract Doc Link 9821153 Disease Relevance 0 Pain Relevance 0.65
These actions at inspiratory XII MN synapses are consistent with those cyclothiazide, which also inhibits AMPA receptor desensitization and slows deactivation [22] They are also consistent with those reported for AMPA/glutamate currents in hippocampal slices [37], and for the high-impact AMPAKINES in general which potently slow the kinetics of both channel closing and desensitization.
Negative_regulation (inhibits) of Negative_regulation (desensitization) of AMPA receptor in synapses associated with glutamate
7) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808240 Disease Relevance 0.16 Pain Relevance 0.23
In the present study, inhibition of NMDA receptors modestly attenuated BRS whereas blockade of AMPA receptors completely abolished baroreflex control of HR.
Negative_regulation (abolished) of Negative_regulation (blockade) of AMPA associated with nmda receptor
8) Confidence 0.08 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2964734 Disease Relevance 0.29 Pain Relevance 0.19
did not fully prevent the suppression of AMPA-mediated EPSPs (see Figure 4(b1)),
Negative_regulation (prevent) of Negative_regulation (suppression) of AMPA
9) Confidence 0.01 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2519792 Disease Relevance 0 Pain Relevance 0.49

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox