INT49706

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1995
Last Reported 2008
Negated 3
Speculated 2
Reported most in Body
Documents 22
Total Number 27
Disease Relevance 12.65
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TNNT2) ATPase activity (TNNT2)
Anatomy Link Frequency
chest 4
internal 1
heart 1
TNNT2 (Homo sapiens)
TNNT2 - R92Q (1)
Pain Link Frequency Relevance Heat
Angina 169 97.60 Very High Very High Very High
cocaine 6 50.00 Quite Low
imagery 1 30.68 Quite Low
ischemia 99 5.00 Very Low Very Low Very Low
Inflammation 76 5.00 Very Low Very Low Very Low
metalloproteinase 20 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Inflammatory marker 4 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asphyxia 9 99.98 Very High Very High Very High
Myocardial Infarction 196 99.96 Very High Very High Very High
Sudden Death 6 99.52 Very High Very High Very High
Muscle Disease 7 99.24 Very High Very High Very High
Coronary Heart Disease 69 99.20 Very High Very High Very High
Stress 48 99.00 Very High Very High Very High
Renal Failure 16 98.68 Very High Very High Very High
Acute Coronary Syndrome 282 98.56 Very High Very High Very High
Injury 136 98.56 Very High Very High Very High
Hypoxia 39 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated cTnT levels have been reported in children with septicemia before [9].
Positive_regulation (Elevated) of cTnT associated with sepsis
1) Confidence 0.69 Published 2006 Journal Crit Care Section Body Doc Link PMC1751080 Disease Relevance 1.12 Pain Relevance 0
The duration of mechanical ventilation was not different between patients with and without elevated cTnT levels, with a median of 3.0 days in both groups (p = 0.66).
Neg (without) Positive_regulation (elevated) of cTnT
2) Confidence 0.69 Published 2006 Journal Crit Care Section Body Doc Link PMC1751080 Disease Relevance 0.33 Pain Relevance 0
CONCLUSION: In patients with clinically documented acute coronary syndrome who are treated with glycoprotein IIb/IIIa inhibitors, even small elevations in cTnI and cTnT identify high-risk patients who derive a large clinical benefit from an early invasive strategy.


Positive_regulation (elevations) of cTnT
3) Confidence 0.67 Published 2001 Journal JAMA Section Body Doc Link 11712935 Disease Relevance 0 Pain Relevance 0
The diagnosis of myocardial infarction (MI) is established in patients with chest pain and equivocal electrocardiogram changes by demonstrating a rise in blood levels of creatine kinase MB (CK-MB) and/or an increase in cardiac troponin I (cTnI) or cardiac troponin T (cTnT).
Positive_regulation (increase) of cTnT in chest associated with angina and myocardial infarction
4) Confidence 0.67 Published 2002 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 11848617 Disease Relevance 0.34 Pain Relevance 0.10
CONCLUSION: We don't observe an increase in c-TNT in the group of cocaine abusers that evidence myocardial cellular damage.


Positive_regulation (increase) of c-TNT
5) Confidence 0.67 Published 2000 Journal An Med Interna Section Body Doc Link 10829457 Disease Relevance 0.16 Pain Relevance 0
RESULTS: An increase in c-TNT or CK was not observed in both groups.
Positive_regulation (increase) of c-TNT
6) Confidence 0.67 Published 2000 Journal An Med Interna Section Body Doc Link 10829457 Disease Relevance 0.16 Pain Relevance 0
In neonates with moderate asphyxia elevated cTnT levels of up to 110 pg/ml on day 7 decreasing to about 30 pg/ml on day 15 of life have been observed [18].
Positive_regulation (elevated) of cTnT associated with asphyxia
7) Confidence 0.61 Published 2006 Journal Crit Care Section Body Doc Link PMC1751080 Disease Relevance 0.45 Pain Relevance 0
METHODS: The diagnostic performances of ECG, creatine kinase (CK) and creatine kinase isoenzyme MB (CKMB) activities, CKMB mass, myoglobin, and cardiac troponin T (cTnT) were compared for early diagnosis of AMI in 60 non-traumatic chest pain patients (22 AMI, 29 unstable angina, nine other diseases) on presentation to an internal medicine emergency department and 1 h thereafter.
Positive_regulation (performances) of cTnT in internal
8) Confidence 0.49 Published 1995 Journal Coron. Artery Dis. Section Body Doc Link 7582192 Disease Relevance 0.19 Pain Relevance 0
Samples were measured for creatine kinase (CK), cardiac troponin T (cTnT), myoglobin, CK isoenzyme MB (CK-MB) and cardiac troponin I (cTnI).
Positive_regulation (measured) of cTnT
9) Confidence 0.49 Published 2001 Journal Ann. Clin. Biochem. Section Abstract Doc Link 11587129 Disease Relevance 0.21 Pain Relevance 0.05
We evaluated cardiac troponin T (cTnT) and creatine kinase-MB (CK-MB) for risk stratification of chest pain unit (CPU) patients.
Positive_regulation (evaluated) of cTnT in chest associated with angina
10) Confidence 0.49 Published 2000 Journal Am. J. Cardiol. Section Abstract Doc Link 10758916 Disease Relevance 0.35 Pain Relevance 0.26
Early sensitivities of creatine kinase (CK), CKMB (activity and mass), CKMM and CKMB isoform ratios, myoglobin, cardiac troponin I (cTnI), and cardiac troponin T (cTnT) were compared to find the most sensitive serum marker for acute myocardial infarction (AMI) during the first hours after onset of chest pain.
Positive_regulation (sensitivities) of cTnT in chest associated with angina and myocardial infarction
11) Confidence 0.49 Published 1995 Journal Clin. Chem. Section Abstract Doc Link 7656437 Disease Relevance 0.52 Pain Relevance 0.17
Cardiac troponin T (cTnT) increased and mostly peaked parallel to cTnI. cTnT sensitivity on the 7th day after AMI was significantly higher than that of cTnI.
Positive_regulation (increased) of cTnT associated with myocardial infarction
12) Confidence 0.49 Published 1996 Journal Clin. Chim. Acta Section Abstract Doc Link 8646813 Disease Relevance 1.35 Pain Relevance 0.47
These marginal elevations of cTnT are associated with increased hospital morbidity and mortality in adult patients following admission [3,4].
Positive_regulation (elevations) of cTnT
13) Confidence 0.47 Published 2006 Journal Crit Care Section Body Doc Link PMC1751080 Disease Relevance 0.53 Pain Relevance 0
In neonates elevation of cTnT may relate to perinatal stress factors [5].
Positive_regulation (elevation) of cTnT associated with stress
14) Confidence 0.47 Published 2006 Journal Crit Care Section Body Doc Link PMC1751080 Disease Relevance 0.44 Pain Relevance 0
Infants with elevated cTnT levels were significantly younger that patients without.
Positive_regulation (elevated) of cTnT
15) Confidence 0.47 Published 2006 Journal Crit Care Section Body Doc Link PMC1751080 Disease Relevance 0.32 Pain Relevance 0
Our objectives were to investigate whether cTnT levels are elevated in infants without congenital heart disease admitted to the paediatric intensive care unit (PICU) and whether levels are associated with increased disease severity.


Spec (whether) Positive_regulation (elevated) of cTnT in heart associated with disease and coronary heart disease
16) Confidence 0.47 Published 2006 Journal Crit Care Section Abstract Doc Link PMC1751080 Disease Relevance 0.63 Pain Relevance 0
Moreover, mutations in the TNNT2 gene (R92Q and ?
Positive_regulation (mutations) of TNNT2 (R92Q)
17) Confidence 0.46 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2630295 Disease Relevance 0.69 Pain Relevance 0
Cardiac Troponin T (cTnT) was found to be positive at 0.1 microg/L using a Cardiac Reader, subsequently confirmed on an Elecsys 1010 (both from Roche Diagnostics, Lewes, UK). cTnT may therefore be a useful biomarker in examining subclinical cardiac involvement in GSD-II patients.
Positive_regulation (positive) of cTnT
18) Confidence 0.45 Published 2007 Journal Ann. Clin. Biochem. Section Abstract Doc Link 17270099 Disease Relevance 0.65 Pain Relevance 0.09
OBJECTIVE: To study if in the chest pain appeared after cocaine consumption a c-TNT increased is objective, showing myocardial cellular damage.
Positive_regulation (increased) of c-TNT in chest
19) Confidence 0.45 Published 2000 Journal An Med Interna Section Body Doc Link 10829457 Disease Relevance 0.19 Pain Relevance 0
cTnT is not normally distributed.
Neg (not) Positive_regulation (distributed) of cTnT
20) Confidence 0.41 Published 2006 Journal Crit Care Section Body Doc Link PMC1751080 Disease Relevance 0.05 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox