INT49731

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Context Info
Confidence 0.44
First Reported 1995
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.95
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Agtr2) transcription factor binding (Agtr2) signal transducer activity (Agtr2)
Agtr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcium channel 4 100.00 Very High Very High Very High
depression 1 99.16 Very High Very High Very High
tricyclic antidepressant 4 98.34 Very High Very High Very High
Desipramine 5 97.76 Very High Very High Very High
narcan 1 94.44 High High
antagonist 7 94.08 High High
opiate 1 93.60 High High
Enkephalin 2 92.96 High High
Analgesic 1 91.20 High High
Opioid 3 90.40 High High
Disease Link Frequency Relevance Heat
Depression 1 99.16 Very High Very High Very High
Pancreatitis 3 90.16 High High
Fibrosis 5 88.16 High High
INFLAMMATION 3 78.56 Quite High
Hypertension 11 59.60 Quite High
Myocardial Infarction 2 5.00 Very Low Very Low Very Low
Cardiovascular Disease 1 5.00 Very Low Very Low Very Low
Headache 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The high dose enhanced the expression of angiotensinogen and angiotensin II receptor type 2 mRNA and suppressed the overexpression of transforming growth factor-beta1 mRNA.
Transcription (expression) of angiotensin II receptor type 2 mRNA
1) Confidence 0.44 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12944495 Disease Relevance 0.74 Pain Relevance 0.65
There was nearly full consensus among our respondents that marketing by pharmaceutical companies is the main explanatory variable for prescribing choices, and particularly the driving force behind the prescribing of newer drugs, such as calcium channel blockers and angiotensin II receptor blockers.
Transcription (prescribing) of angiotensin II receptor associated with calcium channel
2) Confidence 0.20 Published 2005 Journal BMC Health Serv Res Section Body Doc Link PMC1079831 Disease Relevance 0.11 Pain Relevance 0.05
Desipramine (DMI), a tricyclic antidepressant drug used in the treatment of depression, has been shown to increase steady-state levels of glucocorticoid receptor type II (GRII) mRNA in vitro and in vivo.
Transcription (levels) of glucocorticoid receptor type II associated with desipramine, depression and tricyclic antidepressant
3) Confidence 0.08 Published 1995 Journal Brain Res. Section Abstract Doc Link 7583316 Disease Relevance 0.10 Pain Relevance 0.52
DPDPE also was transported by rat Oatp1 (K(m) approximately 48 microM) and Oatp2 (K(m) approximately 19 microM), whereas deltorphin II was only transported by Oatp1 (K(m) approximately 137 microM).
Transcription (transported) of deltorphin II
4) Confidence 0.00 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10871297 Disease Relevance 0 Pain Relevance 0.85

General Comments

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