INT49748

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Context Info
Confidence 0.47
First Reported 1995
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 3.03
Pain Relevance 4.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR2C) nucleus (HTR2C) cytoplasm (HTR2C)
signal transducer activity (HTR2C)
Anatomy Link Frequency
glial cells 1
brain 1
HTR2C (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 23 99.98 Very High Very High Very High
sSRI 13 99.92 Very High Very High Very High
antidepressant 170 99.78 Very High Very High Very High
agonist 29 97.08 Very High Very High Very High
Dopamine 19 97.00 Very High Very High Very High
monoamine 2 96.56 Very High Very High Very High
Potency 4 96.42 Very High Very High Very High
opiate 3 95.76 Very High Very High Very High
Serotonin 27 94.40 High High
noradrenaline 7 93.72 High High
Disease Link Frequency Relevance Heat
Schizophrenia 1 98.96 Very High Very High Very High
Anxiety Disorder 91 93.56 High High
Vomiting 2 92.68 High High
Body Weight 2 91.40 High High
Headache 1 89.60 High High
Hypoglycemia 86 84.48 Quite High
Phobia 1 83.48 Quite High
Impulse Control Disorders 1 81.00 Quite High
Depression 17 80.84 Quite High
Disease 3 76.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further evidence that fluoxetine interacts with a 5-HT2C receptor in glial cells.
5-HT2C Binding (interacts) of in glial cells associated with fluoxetine
1) Confidence 0.47 Published 1995 Journal Brain Res. Bull. Section Title Doc Link 7583341 Disease Relevance 0 Pain Relevance 0.75
It binds equipotently and with the greatest affinity to 5HT2C and 5HT3 receptor subtypes, and to a lesser extent to 5HT1A and 5HT1D receptors (Gross et al 1998; McDougle 1999).
5HT2C Binding (binds) of
2) Confidence 0.47 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2416754 Disease Relevance 0.86 Pain Relevance 0.50
We evaluated the 5-HT2C receptor's role in Ro 60-0175 by studying its interaction with SB-242,084, a selective 5-HT2C antagonist.
5-HT2C Binding (interaction) of
3) Confidence 0.47 Published 2008 Journal Psychopharmacology (Berl.) Section Body Doc Link 17899022 Disease Relevance 0 Pain Relevance 0
Compounds interacting with 5-HT1F, 5-HT2C, 5-HT6 and 5-HT7 receptors are currently under investigation and may prove to have important therapeutic applications in the future.
5-HT2C Binding (interacting) of
4) Confidence 0.47 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11888547 Disease Relevance 0.60 Pain Relevance 0.26
Ibogaine's hallucinogenic effects may be explained by its interactions with 5-HT2A and 5-HT2C receptors, while its putative antiaddictive properties may result from its interactions with sigma 2 and opiate receptors.
5-HT2C Binding (interactions) of associated with opiate
5) Confidence 0.47 Published 2001 Journal Alkaloids Chem Biol Section Abstract Doc Link 11705117 Disease Relevance 0 Pain Relevance 0.19
In addition, we estimated the potencies of 5-HT receptor ligands in inhibiting specific [3H]5-HT binding (in the presence of 8-hydroxy-2(di-n-propylamino)tetralin and mesulergine to prevent binding to 5-HT1A and 5-HT2C sites) to guinea-pig cortical synaptosomes and membranes. 5-HT receptor agonists inhibited the K(+)-evoked tritium overflow from synaptosomes and slices.
5-HT2C Binding (binding) of associated with agonist
6) Confidence 0.47 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8692282 Disease Relevance 0 Pain Relevance 0.23
The inhibitory potency of the drugs was significantly correlated with their affinity for 5-HTID receptors in human brain and for cloned human 5-HT1D alpha and 5-HT1D beta receptors, but not with their affinity for 5-HT1B, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT5B and 5-HT7 receptors.
5-HT2C Neg (not) Binding (affinity) of in brain associated with potency
7) Confidence 0.47 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8692281 Disease Relevance 0 Pain Relevance 0.49
In other receptor binding studies, an affinity for the adrenergic alpha 1 receptor (Ki = 200 nM) and 5-HT2C receptor (Ki = 680 nM) was observed.
5-HT2C Binding (affinity) of
8) Confidence 0.36 Published 1996 Journal Neuropharmacology Section Abstract Doc Link 9025110 Disease Relevance 0.05 Pain Relevance 0.54
The association between antidepressant use and hyperglycaemia was most pronounced for antidepressants with high affinity for the NE reuptake transporter, 5-HT2c receptor and H1 receptor.
5-HT2c Binding (affinity) of associated with antidepressant
9) Confidence 0.36 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2668653 Disease Relevance 0.43 Pain Relevance 0.47
We found that the association between hyperglycaemia and use of antidepressants was most pronounced for antidepressants from cluster 2 and cluster 3 with corresponding binding properties for the NE reuptake transporter, 5-HT2c receptor and H1 receptor.
5-HT2c Binding (binding) of associated with antidepressant
10) Confidence 0.36 Published 2008 Journal Eur J Clin Pharmacol Section Body Doc Link PMC2668653 Disease Relevance 0.78 Pain Relevance 0.33
Affinity for neuroreceptors, such as sigma1, muscarinic and 5-HT2c, also differs widely.
5-HT2c Binding (Affinity) of
11) Confidence 0.35 Published 1998 Journal J. Psychopharmacol. (Oxford) Section Abstract Doc Link 9808077 Disease Relevance 0.31 Pain Relevance 1.00

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