INT49751

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Context Info
Confidence 0.45
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 4.73
Pain Relevance 7.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (PTGS1) small molecule metabolic process (PTGS1) aging (PTGS1)
Golgi apparatus (PTGS1) endoplasmic reticulum (PTGS1) lipid metabolic process (PTGS1)
Anatomy Link Frequency
platelets 3
joint 2
colon 2
mononuclear cells 1
PTGS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 68 99.98 Very High Very High Very High
Paracetamol 34 99.92 Very High Very High Very High
COX2 10 99.92 Very High Very High Very High
acular 15 99.68 Very High Very High Very High
cOX1 9 99.68 Very High Very High Very High
Inflammation 10 99.48 Very High Very High Very High
aspirin 8 98.78 Very High Very High Very High
Inflammatory stimuli 1 98.48 Very High Very High Very High
Analgesic 42 93.36 High High
Potency 18 93.00 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 23 99.48 Very High Very High Very High
Arthropathy 1 98.64 Very High Very High Very High
Reprotox - General 1 1 98.44 Very High Very High Very High
Colon Cancer 4 98.04 Very High Very High Very High
Overdose 2 97.76 Very High Very High Very High
Injury 9 97.20 Very High Very High Very High
Apoptosis 1 95.28 Very High Very High Very High
Toxicity 17 95.08 Very High Very High Very High
Polyps 2 91.92 High High
Cancer 11 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of constitutive and inducible cyclooxygenase activity in human platelets and mononuclear cells by NSAIDs and Cox 2 inhibitors.
Negative_regulation (Inhibition) of Positive_regulation (inducible) of cyclooxygenase in platelets associated with cinod
1) Confidence 0.45 Published 1995 Journal Inflamm. Res. Section Title Doc Link 7583521 Disease Relevance 0 Pain Relevance 0.39
Numerous experimental, epidemiologic, and clinical studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs), particularly the highly selective cyclooxygenase (COX)-2 inhibitors, have promise as anticancer agents.
Negative_regulation (inhibitors) of Positive_regulation (selective) of cyclooxygenase associated with inflammation and cinod
2) Confidence 0.32 Published 2002 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 11854387 Disease Relevance 0.85 Pain Relevance 0.59
All compounds tested were either equipotent at inhibiting constitutive and inducible cyclooxygenase or were selective for the inducible form.
Negative_regulation (inhibiting) of Positive_regulation (inducible) of cyclooxygenase
3) Confidence 0.29 Published 1995 Journal Inflamm. Res. Section Abstract Doc Link 7583521 Disease Relevance 0 Pain Relevance 0.32
The clinical efficacy of non-steroidal anti-inflammatory drugs (NSAIDs) is believed to result from the ability of these compounds to inhibit the inducible isoform of the enzyme cyclooxygenase, COX2.
Negative_regulation (inhibit) of Positive_regulation (inducible) of enzyme cyclooxygenase associated with inflammation, cinod and cox2
4) Confidence 0.16 Published 1996 Journal J. Enzym. Inhib. Section Abstract Doc Link 8835932 Disease Relevance 0.10 Pain Relevance 0.47
Inhibition of constitutive and inducible cyclooxygenase activity in human platelets and mononuclear cells by NSAIDs and Cox 2 inhibitors.
Negative_regulation (Inhibition) of in mononuclear cells Positive_regulation (inducible) of cyclooxygenase in platelets associated with cinod
5) Confidence 0.15 Published 1995 Journal Inflamm. Res. Section Title Doc Link 7583521 Disease Relevance 0 Pain Relevance 0.39
Most existing NSAIDs are unselective and inhibit the activity of the constitutive cyclooxygenase (COX) 1 enzyme in the stomach as much as the cyclooxygenase (COX) 2 enzyme which is induced at sites of inflammation such as joint disease.
Negative_regulation (inhibit) of Positive_regulation (induced) of cyclooxygenase in joint associated with inflammation, cinod and arthropathy
6) Confidence 0.13 Published 1996 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 8898449 Disease Relevance 1.00 Pain Relevance 1.22
The stereoselective inhibition of inducible cyclooxygenase (COX-2) by chiral nonsteroidal antiinflammatory drugs (NSAIDs)--ketoprofen, flurbiprofen, and ketorolac--has been investigated.
Spec (investigated) Negative_regulation (inhibition) of Spec (investigated) Positive_regulation (inducible) of cyclooxygenase associated with inflammation, acular and cinod
7) Confidence 0.11 Published 1996 Journal J Clin Pharmacol Section Abstract Doc Link 8809635 Disease Relevance 0.24 Pain Relevance 0.19
Stereoselective inhibition of inducible cyclooxygenase by chiral nonsteroidal antiinflammatory drugs.
Negative_regulation (inhibition) of Positive_regulation (inducible) of cyclooxygenase associated with inflammation and cox1
8) Confidence 0.11 Published 1996 Journal J Clin Pharmacol Section Title Doc Link 8809635 Disease Relevance 0.27 Pain Relevance 0.42
This effect is due in part to their ability to inhibit the inducible isoform of cyclooxygenase (COX-2).
Negative_regulation (inhibit) of Positive_regulation (inducible) of cyclooxygenase
9) Confidence 0.09 Published 2002 Journal J. Pathol. Section Abstract Doc Link 12434411 Disease Relevance 0.63 Pain Relevance 0.10
NSAIDs inhibit the enzyme cyclooxygenase (COX), reduce the production of prostaglandins at the site of tissue injury, and diminish the inflammatory cascade.
Negative_regulation (inhibit) of Positive_regulation (enzyme) of cyclooxygenase associated with inflammation, injury and cinod
10) Confidence 0.07 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004641 Disease Relevance 0.79 Pain Relevance 1.55
However, high levels of peroxynitrite or other peroxides such as lipid peroxides formed at inflammatory sites might overwhelm the ability of acetaminophen to decrease PGHS activation.
Negative_regulation (decrease) of Positive_regulation (activation) of PGHS associated with paracetamol and inflammation
11) Confidence 0.06 Published 2008 Journal FASEB J. Section Abstract Doc Link 17724253 Disease Relevance 0.10 Pain Relevance 0.83
Anti-inflammatories that selectively inhibit inducible cyclooxygenase (COX)-2 are being investigated in colon as alternatives to the NSAID, which inhibit both COX-1 and COX-2 and derive their toxicity from COX-1 inhibition.
Negative_regulation (inhibit) of Positive_regulation (inducible) of cyclooxygenase in colon associated with toxicity and cinod
12) Confidence 0.03 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10668477 Disease Relevance 0.59 Pain Relevance 0.21
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, and indomethacin (INN, indometacin) inhibit both the constitutive (COX-1) and inducible (COX-2) isoforms of cyclooxygenase.
Negative_regulation (inhibit) of Positive_regulation (inducible) of cyclooxygenase associated with aspirin, inflammation and cinod
13) Confidence 0.01 Published 1999 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 10096266 Disease Relevance 0.17 Pain Relevance 0.53

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