INT49759

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Context Info
Confidence 0.58
First Reported 1995
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 43
Total Number 48
Disease Relevance 52.00
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (CETP) transport (CETP) extracellular space (CETP)
small molecule metabolic process (CETP) extracellular region (CETP) lipid metabolic process (CETP)
Anatomy Link Frequency
blood 3
plasma 3
coronary artery 2
liver 1
heart 1
CETP (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 178 98.68 Very High Very High Very High
alcohol 123 98.22 Very High Very High Very High
Angina 57 97.56 Very High Very High Very High
Bile 231 94.04 High High
headache 25 91.96 High High
Pain 16 83.36 Quite High
imagery 75 76.08 Quite High
cva 36 75.00 Quite High
Inflammation 136 74.32 Quite High
backache 5 64.80 Quite High
Disease Link Frequency Relevance Heat
Hyperlipoproteinemia Type Ii 92 99.90 Very High Very High Very High
Disorder Of Lipid Metabolism 4549 99.88 Very High Very High Very High
Coronary Artery Disease 770 99.72 Very High Very High Very High
Myocardial Infarction 323 99.60 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

330 99.24 Very High Very High Very High
Atherosclerosis 576 99.20 Very High Very High Very High
Coronary Heart Disease 336 99.20 Very High Very High Very High
Cardiovascular Disease 401 99.18 Very High Very High Very High
Disease 131 99.06 Very High Very High Very High
Pressure And Volume Under Development 126 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the effect of increased HDL-C levels caused by partial deficiency of CETP is insufficient to prevent CHD in FH.
Negative_regulation (deficiency) of CETP associated with coronary artery disease, hyperlipoproteinemia type ii and disorder of lipid metabolism
1) Confidence 0.58 Published 1997 Journal Atherosclerosis Section Abstract Doc Link 9242969 Disease Relevance 1.81 Pain Relevance 0.09
To further clarify the characteristics of marked HALP in patients with ACD, we compared the plasma lipids, lipoproteins, CETP, and HTGL activities between heterozygotes for CETP deficiency who were with and without ACD.
Negative_regulation (deficiency) of CETP in plasma associated with cardiovascular disease
2) Confidence 0.57 Published 1995 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 7583564 Disease Relevance 1.25 Pain Relevance 0.09
Ten patients with HALP who had ACD were identified to be heterozygotes for CETP deficiency.
Negative_regulation (deficiency) of CETP associated with cardiovascular disease
3) Confidence 0.57 Published 1995 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 7583564 Disease Relevance 1.15 Pain Relevance 0.10
One potential mechanism of increasing HDL-C is inhibition of cholesteryl ester transfer protein (CETP).
Negative_regulation (inhibition) of CETP associated with disorder of lipid metabolism
4) Confidence 0.51 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.67 Pain Relevance 0.31
One potential mechanism of increasing HDL-C is inhibition of cholesteryl ester transfer protein (CETP).
Negative_regulation (inhibition) of cholesteryl ester transfer protein associated with disorder of lipid metabolism
5) Confidence 0.51 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.67 Pain Relevance 0.31
CETP is synthesized in the liver, and transfers cholesteryl esters from HDL-C to LDL-C or TG-rich lipoproteins in exchange for TG.11 After addition of TG to HDL-C, HDL-C is more readily catabolized in the liver.11 Partial inhibition of CETP is associated with an increase in HDL-C of up to 100%, and may also decrease LDL-C levels.
Spec (Partial) Negative_regulation (inhibition) of CETP in liver associated with disorder of lipid metabolism
6) Confidence 0.51 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 1.58 Pain Relevance 0.23
Combined reduction of cholesteryl ester transfer protein and hepatic triglyceride lipase.
Negative_regulation (reduction) of cholesteryl ester transfer protein
7) Confidence 0.50 Published 1995 Journal Arterioscler. Thromb. Vasc. Biol. Section Title Doc Link 7583564 Disease Relevance 0.86 Pain Relevance 0
We found that familial hyperalphalipoproteinemia can be produced by CETP deficiency due to a CETP gene.
Negative_regulation (deficiency) of CETP
8) Confidence 0.49 Published 1995 Journal Rinsho Byori Section Abstract Doc Link 7739114 Disease Relevance 1.37 Pain Relevance 0.06
Elevated HDL secondary to CETP deficiency may not then be entirely atheroprotective.
Negative_regulation (deficiency) of CETP associated with disorder of lipid metabolism
9) Confidence 0.41 Published 2006 Journal Cardiovasc Diabetol Section Body Doc Link PMC1592077 Disease Relevance 1.04 Pain Relevance 0
Another potential mechanism for increased HDL-C levels in response to statin therapy is by inhibiting CETP activity.
Negative_regulation (inhibiting) of CETP associated with disorder of lipid metabolism
10) Confidence 0.41 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 0.86 Pain Relevance 0
For this reason, partial inhibition of CETP activity has been the focus of novel therapeutic strategies employing CETP inhibition as discussed below.


Negative_regulation (inhibition) of CETP
11) Confidence 0.41 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.13 Pain Relevance 0.07
Mechanisms by which alcohol consumption increases HDL-C may involve changes in Apo AI synthesis and transportation, inhibition of CETP activity and stimulation of early steps in RCT (Van der Gaag et al 2001).
Negative_regulation (inhibition) of CETP associated with disorder of lipid metabolism and alcohol
12) Confidence 0.41 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.07 Pain Relevance 0.25
Accordingly, statin monotherapy may not be efficient for comprehensive management of the lipid profile in these patients and concomitant therapy with other drugs for dyslipidemia, including fibrates and niacins, and cholesteryl ester transfer protein (CETP) inhibitors, which are under development, may be indicated.
Negative_regulation (inhibitors) of CETP
13) Confidence 0.41 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788597 Disease Relevance 1.14 Pain Relevance 0
In this study, the use of dalcetrapib to inhibit CETP activity did not appear to be associated with any off-target, compound-specific, cardiovascular or non-cardiovascular safety concerns, except for an increased incidence of gastrointestinal events and headache.
Negative_regulation (inhibit) of CETP associated with headache
14) Confidence 0.40 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2821630 Disease Relevance 0.76 Pain Relevance 0.09
Decreased plasma levels of CETP are associated with increased levels of HDL-C and, in turn, decreased risk of coronary artery disease (CAD).8–10 These effects have been correlated also with specific mutations in the CETP gene.8,11,12
Negative_regulation (Decreased) of CETP in coronary artery associated with coronary artery disease and disorder of lipid metabolism
15) Confidence 0.40 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2821630 Disease Relevance 1.25 Pain Relevance 0
One potential strategy towards raising HDL-C is through inhibition of cholesteryl ester transfer protein (CETP).
Negative_regulation (inhibition) of cholesteryl ester transfer protein associated with disorder of lipid metabolism
16) Confidence 0.40 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2821630 Disease Relevance 1.24 Pain Relevance 0
One potential strategy towards raising HDL-C is through inhibition of cholesteryl ester transfer protein (CETP).
Negative_regulation (inhibition) of CETP associated with disorder of lipid metabolism
17) Confidence 0.40 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2821630 Disease Relevance 1.24 Pain Relevance 0
Torcetrapib, the first inhibitor of CETP activity to enter extensive evaluation in humans, was associated with increases in blood pressure (BP) in several clinical trials, which appears to be a compound-specific, off-target effect.13–17 Notably, the phase III Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events (ILLUMINATE) trial of torcetrapib in combination with atorvastatin was halted very early due to increased CVD events and all-cause mortality compared with atorvastatin alone;13 further development of torcetrapib was terminated.
Spec (Investigation) Negative_regulation (inhibitor) of CETP in blood associated with pressure and volume under development, cardiovascular disease and atherosclerosis
18) Confidence 0.40 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2821630 Disease Relevance 1.31 Pain Relevance 0
However, two FH patients with CETP deficiency suffered myocardial infarction, and six patients had effort angina pectoris and/or coronary atherosclerosis.
Negative_regulation (deficiency) of CETP associated with angina, coronary artery disease, hyperlipoproteinemia type ii and myocardial infarction
19) Confidence 0.37 Published 1997 Journal Atherosclerosis Section Abstract Doc Link 9242969 Disease Relevance 1.69 Pain Relevance 0.10
These findings suggest that the atherogenicity of hyper-LDL-cholesterolemia in FH is more powerful than antiatherogenicity of hyper-HDL-cholesterolemia in CETP deficiency.
Negative_regulation (deficiency) of CETP associated with hyperlipoproteinemia type ii and disorder of lipid metabolism
20) Confidence 0.36 Published 1995 Journal Rinsho Byori Section Abstract Doc Link 7739114 Disease Relevance 1.15 Pain Relevance 0.09

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