INT49761

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Context Info
Confidence 0.62
First Reported 1994
Last Reported 2005
Negated 3
Speculated 4
Reported most in Abstract
Documents 6
Total Number 9
Disease Relevance 3.83
Pain Relevance 7.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf) extracellular space (Ngf) aging (Ngf)
extracellular region (Ngf) molecular_function (Ngf)
Anatomy Link Frequency
nerve 6
sensory neurons 2
spinal cord 2
astrocytes 2
Ngf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 208 100.00 Very High Very High Very High
Inflammation 23 100.00 Very High Very High Very High
agonist 12 100.00 Very High Very High Very High
Spinal cord 9 100.00 Very High Very High Very High
substance P 7 100.00 Very High Very High Very High
Enkephalin 2 100.00 Very High Very High Very High
qutenza 67 99.82 Very High Very High Very High
trigeminal ganglion 59 99.24 Very High Very High Very High
Pain 12 99.20 Very High Very High Very High
Hyperalgesia 14 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 19 100.00 Very High Very High Very High
Ganglion Cysts 74 99.24 Very High Very High Very High
Pain 8 99.20 Very High Very High Very High
Hyperalgesia 18 99.16 Very High Very High Very High
Nociception 9 98.82 Very High Very High Very High
Polycystic Ovary Syndrome 64 94.04 High High
Hypersensitivity 6 93.72 High High
Hypoalagesia 1 83.80 Quite High
Injury 25 83.00 Quite High
Follicular Cyst 3 70.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The capsaicin-induced increase of NGF was not significantly affected by indomethacin administered at a dose (2 mg/kg) that abolishes prostaglandin E2 biosynthesis.
Neg (not) Regulation (affected) of Positive_regulation (increase) of NGF associated with nerve growth factor and qutenza
1) Confidence 0.62 Published 2004 Journal Pain Section Abstract Doc Link 15494187 Disease Relevance 0.25 Pain Relevance 1.17
We have now examined whether the elevation in nerve growth factor (NGF) induced by the inflammation contributes to this progressive hyperalgesia.
Spec (whether) Regulation (contributes) of Spec (whether) Positive_regulation (elevation) of NGF in nerve associated with hyperalgesia, inflammation and nerve growth factor
2) Confidence 0.45 Published 1997 Journal Neuroreport Section Abstract Doc Link 9141043 Disease Relevance 0.89 Pain Relevance 0.70
We have now examined whether the elevation in nerve growth factor (NGF) induced by the inflammation contributes to this progressive hyperalgesia.
Spec (whether) Regulation (contributes) of Spec (whether) Positive_regulation (elevation) of nerve growth factor in nerve associated with hyperalgesia, inflammation and nerve growth factor
3) Confidence 0.45 Published 1997 Journal Neuroreport Section Abstract Doc Link 9141043 Disease Relevance 0.89 Pain Relevance 0.70
Terbutaline also inhibited the increase in NGF caused by intraplantar injection of the NK1 receptor agonist substance P (SP), but did not significantly affect that caused by carrageenan.
Neg (not) Regulation (affect) of Positive_regulation (increase) of NGF associated with nerve growth factor, agonist and substance p
4) Confidence 0.45 Published 2004 Journal Pain Section Abstract Doc Link 15494187 Disease Relevance 0.19 Pain Relevance 1.29
Treatment of newborn rats for 7 days with the opiate antagonist naltrexone, prior to preparation of astrocytes, had no effect on PE mRNA or met-enkephalin content but resulted in a significant increase in NGF content.
Neg (no) Regulation (effect) of Positive_regulation (increase) of NGF in astrocytes associated with nerve growth factor, antagonist, enkephalin and opiate
5) Confidence 0.45 Published 1994 Journal Glia Section Abstract Doc Link 7927646 Disease Relevance 0 Pain Relevance 1.07
In addition, the concentration of NGF protein and the expression of NGF mRNA in the ovary, the adrenal gland, and the spinal cord were analysed.
Spec (analysed) Regulation (analysed) of Positive_regulation (concentration) of NGF protein in spinal cord associated with nerve growth factor and spinal cord
6) Confidence 0.44 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC155675 Disease Relevance 0.39 Pain Relevance 0.45
Both the NGF- and GDNF-induced upregulation of TRPV1 appears to be translationally regulated, as neither of these growth factors altered TRPV1 mRNA levels.
Spec (appears) Regulation (regulated) of Positive_regulation (upregulation) of NGF associated with nerve growth factor
7) Confidence 0.43 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.59 Pain Relevance 0.72
In the combination model, there were more pronounced changes in nerve growth factor induction and both mechanical and thermal threshold during 7 days after surgery (P < 0.05).
Regulation (changes) of Positive_regulation (induction) of nerve growth factor in nerve
8) Confidence 0.26 Published 2005 Journal Spine Section Body Doc Link 15644754 Disease Relevance 0 Pain Relevance 0
These data suggest that peripherally produced NGF normally acts to maintain the sensitivity of nociceptive sensory neurons and that, in some inflammatory states, an upregulation of NGF is responsible for alterations in pain-related behaviour.
Regulation (responsible) of Positive_regulation (upregulation) of NGF in sensory neurons associated with nociception, pain, inflammation and nerve growth factor
9) Confidence 0.25 Published 1995 Journal Nat. Med. Section Abstract Doc Link 7585179 Disease Relevance 0.64 Pain Relevance 1.01

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