INT49769

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Context Info
Confidence 0.48
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.39
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SSTR2) cell-cell signaling (SSTR2) cytoplasm (SSTR2)
signal transducer activity (SSTR2)
SSTR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 120 100.00 Very High Very High Very High
Morphine 10 99.98 Very High Very High Very High
Opioid 6 99.98 Very High Very High Very High
agonist 5 94.28 High High
mu opioid receptor 2 91.04 High High
imagery 7 16.32 Low Low
Dopamine 7 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 4 99.24 Very High Very High Very High
Growth Hormone-secreting Pituitary Adenoma 5 82.24 Quite High
Carcinoid 22 82.00 Quite High
Pituitary Cancer 35 79.44 Quite High
Cancer 163 78.84 Quite High
Alzheimer's Dementia 6 69.68 Quite High
Acromegaly 2 63.76 Quite High
Neuroendocrine Cancer 11 50.00 Quite Low
Adenoma 79 48.36 Quite Low
Metastasis 15 43.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine cross-reacts with somatostatin receptor SSTR2 in the T47D human breast cancer cell line and decreases cell growth.
SSTR2 Binding (cross-reacts) of associated with breast cancer, somatostatin and morphine
1) Confidence 0.48 Published 1995 Journal Cancer Res. Section Title Doc Link 7585646 Disease Relevance 0.19 Pain Relevance 0.82
Further analysis indicated that mu-acting opioids interact with the SSTR2 receptor subtype.
SSTR2 receptor Binding (interact) of associated with opioid
2) Confidence 0.48 Published 1995 Journal Cancer Res. Section Abstract Doc Link 7585646 Disease Relevance 0.13 Pain Relevance 0.83
The effects of the SST analogues are mediated by the interaction with SSTR 2 and 5 receptors while the new somatostatin analogue, pasireotide (SOM 230), shows higher binding capacity towards SSTRs 1, 2, 3 and 5 with no agonist activity at the type 4 receptor [15] (Table 3).
SSTR 2 Binding (interaction) of associated with agonist and somatostatin
3) Confidence 0.40 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.08 Pain Relevance 0.40
They concluded that the percentage of cell membrane immunopositive for SSTR2 is associated with the hormone inhibitory effect, so immunohistochemical analysis of SSTR in GHoma could provide important information for predicting the likelihood of successfully employing SSAs in adjuvant therapy (Fig. 4f).


SSTR2 Binding (associated) of
4) Confidence 0.21 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2522328 Disease Relevance 0.99 Pain Relevance 0.08

General Comments

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