INT4977

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Context Info
Confidence 0.46
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 60
Total Number 60
Disease Relevance 42.48
Pain Relevance 15.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ITIH4) plasma membrane (ITIH4) cytoplasm (ITIH4)
Anatomy Link Frequency
macrophages 4
neurons 3
microglia 2
neuronal 2
nerves 2
ITIH4 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 532 100.00 Very High Very High Very High
Peripheral nervous system 8 99.84 Very High Very High Very High
Calcium channel 20 99.76 Very High Very High Very High
Pain 209 99.68 Very High Very High Very High
Brush evoked pain 5 99.36 Very High Very High Very High
antagonist 387 99.34 Very High Very High Very High
nMDA receptor 102 99.12 Very High Very High Very High
allodynia 15 99.00 Very High Very High Very High
Opioid 71 98.56 Very High Very High Very High
addiction 421 98.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 3153 100.00 Very High Very High Very High
Toxicity 358 100.00 Very High Very High Very High
Gliosis 54 99.98 Very High Very High Very High
Apoptosis 262 99.92 Very High Very High Very High
Pain 159 99.68 Very High Very High Very High
Infection 743 99.66 Very High Very High Very High
Hypersensitivity 206 99.52 Very High Very High Very High
Injury 285 99.44 Very High Very High Very High
Viral Infection 20 99.38 Very High Very High Very High
Neuropathic Pain 382 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, recent findings showing the presence of chemokine receptors on the surface of different cell types resident in the CNS raise the possibility that the association of gp120 with these receptors may contribute to the pathogenesis of neurological dysfunction.
gp120 Binding (association) of associated with chemokine and anesthesia
1) Confidence 0.46 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10820198 Disease Relevance 1.76 Pain Relevance 0.33
Binding of gp120 to macrophages stimulates the cells to release various pro-inflammatory cytokines, including TNF-alpha, which has been shown to regulate transcription of the MOR gene.
gp120 Binding (Binding) of in macrophages associated with inflammation, mu opioid receptor and cytokine
2) Confidence 0.43 Published 2006 Journal Int. Immunopharmacol. Section Abstract Doc Link 16846840 Disease Relevance 0.69 Pain Relevance 0.61
These findings, together with our previous reports, suggest that the neuronal injury observed in HIV-1 infection could be due to direct (or indirect) interactions between the viral protein gp120 and chemokine and/or NMDA receptors.
gp120 Binding (interactions) of in neuronal associated with chemokine, nmda receptor, acquired immune deficiency syndrome or hiv infection, injury and infection
3) Confidence 0.40 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10820198 Disease Relevance 0.81 Pain Relevance 0.29
We investigated the binding of the gp120 glycoprotein of the human immunodeficiency virus (HIV-1) to neural glycolipids and glycoproteins by ELISA.
gp120 Binding (binding) of in neural associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.39 Published 1992 Journal J. Neurosci. Res. Section Abstract Doc Link 1282933 Disease Relevance 0.51 Pain Relevance 0.08
Based on experiments with the selective calcium channel antagonist nimodipine, it appears that the gp120 causes its effects by irreversible binding to a calcium channel.
gp120 Binding (binding) of associated with antagonist and calcium channel
5) Confidence 0.37 Published 1993 Journal J. Neuroimmunol. Section Abstract Doc Link 8458986 Disease Relevance 0.19 Pain Relevance 0.21
Decreases in response thresholds to both heat stimuli (thermal hyperalgesia) and light tactile stimuli (mechanical allodynia) are rapidly induced after gp120 administration. gp120 is the portion of HIV-1 that binds to and activates microglia and astrocytes.
gp120 Binding (binds) of in astrocytes associated with allodynia, thermal hyperalgesia and acquired immune deficiency syndrome or hiv infection
6) Confidence 0.35 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11306633 Disease Relevance 1.25 Pain Relevance 1.01
Opioid compounds have yielded the mixed results when attempting to determine their interaction with the gp120 or the Tat.
gp120 Binding (interaction) of associated with opioid
7) Confidence 0.33 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 1.03 Pain Relevance 0.63
Initial hypotheses included gp120 direct interactions with neurons resulting in apoptosis, stimulation of astrocytes/microglia resulting in indirect effects
gp120 Binding (interactions) of in microglia associated with apoptosis
8) Confidence 0.33 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 1.01 Pain Relevance 0.23
Morphine amplified the effect of tubular cell-gp120 interaction on the proliferation of KF.
cell-gp120 Binding (interaction) of
9) Confidence 0.32 Published 1998 Journal J. Investig. Med. Section Body Doc Link 9676058 Disease Relevance 0 Pain Relevance 0
Through its surface glycoprotein, gp120, HIV-1 binds to surface receptors on target cells, including macrophages, to exert its pathological effects.
gp120 Binding (binds) of in macrophages associated with acquired immune deficiency syndrome or hiv infection
10) Confidence 0.32 Published 2006 Journal Int. Immunopharmacol. Section Abstract Doc Link 16846840 Disease Relevance 0.68 Pain Relevance 0.51
In addition, the alpha chemokine SDF1alpha and the beta chemokines MIP1alpha, MIP1beta, and RANTES, natural ligands of CXCR4 and CCR5, respectively, are potent soluble inhibitors of HIV infection by blocking the binding between the viral envelope glycoprotein gp120 and the coreceptors.
gp120 Binding (binding) of associated with chemokine, acquired immune deficiency syndrome or hiv infection and infection
11) Confidence 0.30 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10820198 Disease Relevance 1.71 Pain Relevance 0.17
Two proteins associated with the AIDS virus, gp120 (a coat glycoprotein) and Tat (transactivation) have been shown to be neurotoxic.
gp120 Binding (associated) of associated with acquired immune deficiency syndrome or hiv infection
12) Confidence 0.29 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 0.75 Pain Relevance 0.08
Amos Smith (University of Pennsylvania), is an entry inhibitor that has been proposed to function through inhibition of CD4 binding [79,80]; however, other evidences indicate that it may bind to unliganded gp120 and target the CD4-induced conformational re-arrangement of gp120 and gp41 [81,82].
gp120 Binding (bind) of
13) Confidence 0.28 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0.13 Pain Relevance 0
Our results suggest a universal inhibitory mechanism is occurring since the invertebrate immunocytes must recognize HIV gp120 peptide to result in this effect, possibly through a CD4 or other type of surface determinant.
gp120 Binding (recognize) of associated with acquired immune deficiency syndrome or hiv infection
14) Confidence 0.28 Published 1993 Journal J. Neuroimmunol. Section Abstract Doc Link 8458986 Disease Relevance 0.28 Pain Relevance 0.19
In the mid and low dosage groups, binding antibodies to gp120 were detected only after the third dose of ADMVA, while in a subset of volunteers in the high dosage group, binding antibodies were detected after the first and/or second vaccinations, although the majority of vaccine recipients also required three injections.
gp120 Binding (binding) of
15) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810329 Disease Relevance 0.58 Pain Relevance 0
Both gp120 and Tat have been shown to induce
gp120 Binding (induce) of
16) Confidence 0.26 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 1.00 Pain Relevance 0.07
heroin, and their derivatives) act primarily at the mu-subtype, which is the subtype primarily responsible for synergistic toxicity with gp120 and Tat.
gp120 Binding (toxicity) of associated with toxicity
17) Confidence 0.26 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 0.95 Pain Relevance 0.83
Both gp120 and Tat have been shown to induce
gp120 Binding (Both) of
18) Confidence 0.26 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 0.98 Pain Relevance 0.07
associated with gp120 and Tat toxicity.
gp120 Binding (associated) of associated with toxicity
19) Confidence 0.25 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 1.02 Pain Relevance 0.33
Anti-gp120 binding antibodies were elicited in all three dose groups after the three injections of ADMVA, although one responder formed antibodies after one vaccination with high dose ADMVA, and five responders formed anti-gp120 antibodies after two vaccinations.
gp120 Binding (binding) of
20) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2810329 Disease Relevance 0.23 Pain Relevance 0.04

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