INT49770

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Context Info
Confidence 0.26
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 0.86
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (FCAR) plasma membrane (FCAR)
Anatomy Link Frequency
B cells 1
FCAR (Homo sapiens)
Pain Link Frequency Relevance Heat
abatacept 15 100.00 Very High Very High Very High
rheumatoid arthritis 1 84.28 Quite High
Arthritis 1 52.56 Quite High
Enkephalin 2 25.00 Low Low
Chronic pancreatitis 5 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Prostatitis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 7 99.12 Very High Very High Very High
Rheumatoid Arthritis 2 84.28 Quite High
Cancer 1 80.00 Quite High
Disease 11 73.76 Quite High
Pancreatitis 33 63.52 Quite High
Apoptosis 1 58.04 Quite High
Autoimmune Disease 7 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Pancreatic Cancer 4 5.00 Very Low Very Low Very Low
Bullous Skin Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To evaluate the ability of different peptide ligands to induce a signal directly on lymphoma cells, thereby establishing their relative affinity to the surface immunoglobulin receptor, acidification rate changes were measured at varying peptide concentrations.
immunoglobulin receptor Binding (affinity) of associated with lymphatic system cancer
1) Confidence 0.26 Published 1995 Journal Cancer Res. Section Abstract Doc Link 7585648 Disease Relevance 0.58 Pain Relevance 0
Fc receptor binding was analyzed in vitro by flow cytometry and surface plasmon resonance (SPR).
Fc receptor Binding (binding) of
2) Confidence 0.26 Published 2007 Journal J. Rheumatol. Section Body Doc Link 17787038 Disease Relevance 0 Pain Relevance 0
CONCLUSION: Abatacept does not mediate CDC or ADCC of target B cells in vitro and has limited Fc receptor binding.
Fc receptor Binding (binding) of in B cells
3) Confidence 0.26 Published 2007 Journal J. Rheumatol. Section Body Doc Link 17787038 Disease Relevance 0 Pain Relevance 0
Abatacept was found to minimally bind the high-affinity Fc receptor CD69 as measured by flow cytometry and SPR with a Kd of 3 X 10-7 M as measured by SPR.
Fc receptor Binding (bind) of
4) Confidence 0.22 Published 2007 Journal J. Rheumatol. Section Body Doc Link 17787038 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: To assess the ability of abatacept to mediate complement-dependent cytotoxicity (CDC) or antibody-dependent cellular cytotoxicity (ADCC) of antigen-presenting cells, and to characterize the binding of abatacept to the 3 Fc receptor classes.
Fc receptor Binding (binding) of associated with abatacept
5) Confidence 0.22 Published 2007 Journal J. Rheumatol. Section Abstract Doc Link 17787038 Disease Relevance 0 Pain Relevance 0.27
Abatacept binds to the Fc receptor CD64 but does not mediate complement-dependent cytotoxicity or antibody-dependent cellular cytotoxicity.
Fc receptor Binding (binds) of associated with abatacept
6) Confidence 0.22 Published 2007 Journal J. Rheumatol. Section Title Doc Link 17787038 Disease Relevance 0 Pain Relevance 0.28
It is equally noteworthy that this IgG4 Fc–Ig Fc interaction extends beyond man to a number of other animal IgG.
Ig Fc Binding (interaction) of
7) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2249926 Disease Relevance 0.27 Pain Relevance 0.07

General Comments

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