INT49774

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Context Info
Confidence 0.48
First Reported 1995
Last Reported 2010
Negated 7
Speculated 2
Reported most in Body
Documents 48
Total Number 50
Disease Relevance 17.42
Pain Relevance 20.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (DRD2) plasma membrane (DRD2) signal transducer activity (DRD2)
Anatomy Link Frequency
brain 2
caudate nucleus 1
striatum 1
forebrain 1
amygdala 1
DRD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 655 100.00 Very High Very High Very High
Catechol-O-methyltransferase 294 100.00 Very High Very High Very High
Multiple sclerosis 173 100.00 Very High Very High Very High
Pain 119 100.00 Very High Very High Very High
Neurotransmitter 88 100.00 Very High Very High Very High
dopamine receptor 82 100.00 Very High Very High Very High
narcan 29 100.00 Very High Very High Very High
Ventral tegmentum 23 99.92 Very High Very High Very High
rapifen 30 99.80 Very High Very High Very High
withdrawal 52 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 101 100.00 Very High Very High Very High
Substance Withdrawal Syndrome 12 99.76 Very High Very High Very High
Alcohol Addiction 52 99.68 Very High Very High Very High
Migraine With Aura 30 99.60 Very High Very High Very High
Headache 73 99.40 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 198 99.30 Very High Very High Very High
Drug Dependence 55 99.20 Very High Very High Very High
Pain 134 99.04 Very High Very High Very High
Demyelinating Disease 87 98.98 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

4 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dopamine D2 receptor binding in the human brain is associated with the response to painful stimulation and pain modulatory capacity.
Dopamine D2 receptor Binding (binding) of in brain associated with pain and dopamine
1) Confidence 0.48 Published 2002 Journal Pain Section Title Doc Link 12237205 Disease Relevance 0.66 Pain Relevance 1.21
Conversely, Lee et al. [20] found no association between these three DRD2 polymorphisms and NS or HA scores, within a young Korean sample.
DRD2 Neg (no) Binding (association) of
2) Confidence 0.48 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1779796 Disease Relevance 0 Pain Relevance 0.10
These results indicate that pharmacologically relevant concentrations of alfentanil increase D2 dopamine receptor binding in the striatum in man.
D2 dopamine receptor Binding (binding) of in striatum associated with rapifen and dopamine receptor
3) Confidence 0.48 Published 2002 Journal Synapse Section Abstract Doc Link 12112410 Disease Relevance 0.23 Pain Relevance 0.85
Mu-receptor agonism with alfentanil increases striatal dopamine D2 receptor binding in man.
dopamine D2 receptor Binding (binding) of associated with rapifen and dopamine
4) Confidence 0.48 Published 2002 Journal Synapse Section Title Doc Link 12112410 Disease Relevance 0.14 Pain Relevance 0.99
Statistical analysis revealed a significant association between the DRD2 TaqI A genotypes and "Eros" (a loving style characterized by a tendency to develop intense emotional experiences based on physical attraction to the partner), thus supporting hedonism as a "wanting" or "SEEKING" phenomena.
DRD2 Binding (association) of
5) Confidence 0.47 Published 2008 Journal Theor Biol Med Model Section Body Doc Link PMC2615745 Disease Relevance 0 Pain Relevance 0.27
In migraine patients only few studies on dopamine D2 receptor binding have been reported.
dopamine D2 receptor Binding (binding) of associated with dopamine and migraine
6) Confidence 0.46 Published 1995 Journal Cephalalgia Section Abstract Doc Link 7585929 Disease Relevance 0.25 Pain Relevance 0.39
We used positron emission tomography (PET) to study the effects of alfentanil (a mu-opioid receptor agonist) on striatal dopamine D2 receptor binding in eight healthy male volunteers.
dopamine D2 receptor Binding (binding) of associated with rapifen, dopamine, agonist, positron emission tomography and opioid receptor
7) Confidence 0.41 Published 2002 Journal Synapse Section Abstract Doc Link 12112410 Disease Relevance 0.13 Pain Relevance 0.78
The pain modulatory role of dopamine D2 receptors of the human forebrain was studied by determining the association between dopamine D2 receptor binding potential and the response to experimental pain.
dopamine D2 receptor Binding (association) of in forebrain associated with pain and dopamine
8) Confidence 0.37 Published 2002 Journal Pain Section Abstract Doc Link 12237205 Disease Relevance 0.40 Pain Relevance 0.69
We found no significant interactions of DRD2 TaqI A1 allele × COMT Val allele for either HA or NS, within either sample (Table 1).
DRD2 Neg (no) Binding (interactions) of associated with catechol-o-methyltransferase
9) Confidence 0.37 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1779796 Disease Relevance 0 Pain Relevance 0.25
For example, the functional effects associated with the DRD2 TaqI A polymorphism may be due to the polymorphism being located within the regulatory region of the ankyrin repeat and kinase domain containing 1 (ANKK1) gene [26] or being in linkage disequilibrium with another DRD2 variant.
DRD2 Binding (associated) of
10) Confidence 0.37 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1779796 Disease Relevance 0.08 Pain Relevance 0
No significant association of gender with genotype or allele frequency of DRD2 and COMT was observed in either sample.
DRD2 Neg (No) Binding (association) of associated with catechol-o-methyltransferase
11) Confidence 0.37 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1779796 Disease Relevance 0 Pain Relevance 0.29
Similarly, Noble et al. [10] found that DRD2, examined either as the TaqI A allele or as a haplotype, was not associated with HA.
DRD2 Binding (associated) of
12) Confidence 0.37 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1779796 Disease Relevance 0 Pain Relevance 0.12
Moreover, dopamine release in the VTA is linked to polymorphisms of the DRD2 gene and even attention-deficit hyperactivity disorder (ADHD), whereby carriers of the DRD2 A1 allele show a reduced NAc release of dopamine (DA).
DRD2 Binding (linked) of in NAc associated with nucleus accumbens, ventral tegmentum, dopamine and attention deficit hyperactivity disorder
13) Confidence 0.37 Published 2010 Journal Med. Hypotheses Section Abstract Doc Link 19914781 Disease Relevance 0.50 Pain Relevance 1.02
Blum et al. [10] provided the first evidence that the dopamine D2 receptor gene (DRD2) Taq 1 A1 allele significantly associated with severe alcoholism whereby the author's suggested that they found the first "reward gene" located in the mesolimbic system.
DRD2 Binding (associated) of associated with alcohol addiction and dopamine
14) Confidence 0.37 Published 2010 Journal Med. Hypotheses Section Abstract Doc Link 19914781 Disease Relevance 0.33 Pain Relevance 0.66
Within the dopamine system, Retz et al. [45] found an association between heterozygotes of the DRD3 single nucleotide polymorphism (SNP) and increased impulsivity, and Limosin et al. [46] found an association with the A2 alleles of the DRD2 TaqI A SNP and increased impulsivity in alcoholics, but both represent isolated reports.
DRD2 TaqI Binding (association) of associated with dopamine and attention deficit hyperactivity disorder
15) Confidence 0.36 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1781951 Disease Relevance 0.64 Pain Relevance 0.05
The significant association with the DRD2/NcoI polymorphism in responders suggested that the DRD2/NcoI C allele may be considered a susceptibility factor heralding a good response to rizatriptan.
DRD2 Binding (association) of
16) Confidence 0.36 Published 2007 Journal J Headache Pain Section Abstract Doc Link 17563839 Disease Relevance 0.24 Pain Relevance 0.36
In fact, as reported above, an association between DRD2 gene and MA has been demonstrated [44, 51].
DRD2 Binding (association) of associated with migraine with aura
17) Confidence 0.36 Published 2007 Journal J Headache Pain Section Body Doc Link PMC2779399 Disease Relevance 0.86 Pain Relevance 0.73
This study aimed to examine support for an association of DRD2 and COMT with behavioural activation, using the TCI within two independent samples of depressed outpatients (for both samples n = 146).


DRD2 Spec (examine) Binding (association) of associated with catechol-o-methyltransferase
18) Confidence 0.36 Published 2007 Journal Behav Brain Funct Section Abstract Doc Link PMC1779796 Disease Relevance 0 Pain Relevance 0.17
Noble et al. [10] reported a significant association of NS with the DRD2 TaqI A polymorphism and DRD2 haplotype (TaqI A, TaqI B and intron 6 polymorphisms), although the association was significant for only one NS subscale.
DRD2 Binding (association) of
19) Confidence 0.36 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1779796 Disease Relevance 0 Pain Relevance 0.13
Similarly, there was no significant association of age and DRD2 or COMT.


DRD2 Neg (no) Binding (association) of associated with catechol-o-methyltransferase
20) Confidence 0.36 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1779796 Disease Relevance 0 Pain Relevance 0.27

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