INT49801

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Context Info
Confidence 0.48
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 21.34
Pain Relevance 5.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SELP) cell adhesion (SELP) nucleolus (SELP)
plasma membrane (SELP) nucleus (SELP) cytoplasm (SELP)
Anatomy Link Frequency
platelet 9
endothelium 2
plasma 1
macrophages 1
leukocyte 1
SELP (Homo sapiens)
Pain Link Frequency Relevance Heat
Percutaneous transluminal coronary angioplasty 27 99.72 Very High Very High Very High
Inflammatory marker 13 99.40 Very High Very High Very High
Delta-9-tetrahydrocannabinol 9 98.72 Very High Very High Very High
aspirin 32 98.68 Very High Very High Very High
tolerance 25 98.08 Very High Very High Very High
Angina 80 97.54 Very High Very High Very High
Cannabinoid receptor 4 94.76 High High
anesthesia 1 92.56 High High
Inflammation 248 92.32 High High
Cannabinoid 1 90.80 High High
Disease Link Frequency Relevance Heat
Adhesions 614 100.00 Very High Very High Very High
Necrosis 7 99.46 Very High Very High Very High
INFLAMMATION 297 99.40 Very High Very High Very High
Cancer 70 99.28 Very High Very High Very High
Acute Coronary Syndrome 52 99.28 Very High Very High Very High
Heart Rate Under Development 9 99.16 Very High Very High Very High
Nicotine Addiction 1175 99.08 Very High Very High Very High
Impaired Glucose Tolerance 19 98.76 Very High Very High Very High
Urological Neuroanatomy 10 98.12 Very High Very High Very High
Cv General 3 Under Development 71 97.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoreactive positive areas for GP IIb/IIIa, P-selectin, and macrophages, respectively, were calculated using computer-aided planimetry, and numbers of neutrophils were also counted.
Positive_regulation (areas) of P-selectin in macrophages
1) Confidence 0.48 Published 2005 Journal Int. J. Mol. Med. Section Abstract Doc Link 15754016 Disease Relevance 0.97 Pain Relevance 0.81
In the culprit lesions of UAP patients, 17 of the 23 lesions (74%) contained GP IIb/IIIa positive platelet thrombi, and all these platelet thrombi were positive for P-selectin.
Positive_regulation (positive) of P-selectin in platelet associated with angina
2) Confidence 0.45 Published 2005 Journal Int. J. Mol. Med. Section Abstract Doc Link 15754016 Disease Relevance 1.12 Pain Relevance 0.98
Platelet reactivity was assessed by flow cytometry measurements of P-selectin (CD62P) and activated GpIIb/IIIa complex (PAC-1).
Positive_regulation (activated) of P-selectin in Platelet associated with heart rate under development
3) Confidence 0.40 Published 2006 Journal Purinergic Signal Section Abstract Doc Link PMC2096644 Disease Relevance 0.18 Pain Relevance 0.04
Platelet reactivity was assessed by flow cytometry measurements of P-selectin (CD62P) and activated GpIIb/IIIa complex (PAC-1).
Positive_regulation (activated) of CD62P in Platelet associated with heart rate under development
4) Confidence 0.40 Published 2006 Journal Purinergic Signal Section Abstract Doc Link PMC2096644 Disease Relevance 0.18 Pain Relevance 0.04
The effects of THC (final concentrations 10(-7) to 10(-5) M) on the expression of activated platelet fibrinogen receptor (glycoprotein IIb-IIIa) and P selectin were characterized by flow cytometry.
Positive_regulation (activated) of P selectin in platelet associated with delta-9-tetrahydrocannabinol
5) Confidence 0.36 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15385362 Disease Relevance 0.57 Pain Relevance 0.60
[Dynamic observation of alpha-granule membrane protein 140 during the treatment of thrombolytic and anticoagulant therapy in patients with acute myocardial infarction].
Positive_regulation (observation) of alpha-granule membrane protein associated with myocardial infarction
6) Confidence 0.33 Published 1995 Journal Zhonghua Nei Ke Za Zhi Section Title Doc Link 7587606 Disease Relevance 0.37 Pain Relevance 0
The increased surface of P-selectin on platelets is not affected by aspirin administration (2 weeks at 100 mg/day) [112].


Positive_regulation (increased) of P-selectin in platelets associated with aspirin
7) Confidence 0.32 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.95 Pain Relevance 0.21
However, Schaberg et al. [93] went on to observe a large increase in ICAM-1, but not P-selectin, E-selectin, or VCAM-1, expression by the endothelium of peripheral pulmonary vessels in smokers, compared to non-smokers.
Positive_regulation (increase) of P-selectin in endothelium associated with nicotine addiction
8) Confidence 0.32 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.33 Pain Relevance 0.04
The increased surface of P-selectin on platelets is not affected by aspirin administration (2 weeks at 100 mg/day) [112].


Positive_regulation (increased) of P-selectin in platelets associated with aspirin
9) Confidence 0.32 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.95 Pain Relevance 0.21
However, Schaberg et al. [93] went on to observe a large increase in ICAM-1, but not P-selectin, E-selectin, or VCAM-1, expression by the endothelium of peripheral pulmonary vessels in smokers, compared to non-smokers.
Positive_regulation (increase) of P-selectin in endothelium associated with nicotine addiction
10) Confidence 0.32 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.33 Pain Relevance 0.04
Another case-control study involving participants from the WomenÂ’s Health Study found a significant association between elevated soluble P-selectin levels and CS consumption (

Ridker and others, 2001a

).

Positive_regulation (elevated) of P-selectin
11) Confidence 0.29 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688374 Disease Relevance 0.82 Pain Relevance 0.12
Some common parameters are actually recommended for risk stratification (Troponine, CRP and BNP or pro-BNP), some others could become important to identify patients at higher risk: the more promising seem to be parameters of platelet activation (P-selectin and t-PA) and inflammatory markers mediators (MPO) (figure 1).
Positive_regulation (activation) of P-selectin in platelet associated with inflammatory marker and urological neuroanatomy
12) Confidence 0.27 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.00 Pain Relevance 0.08
Osterud et al. [224] found a small, but significant, rise in sP-selectin in the serum of women smokers, compared to non-smokers, that was not apparent in the male or in the total study population.
Positive_regulation (rise) of sP-selectin associated with nicotine addiction
13) Confidence 0.26 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.66 Pain Relevance 0
Osterud et al. [224] found a small, but significant, rise in sP-selectin in the serum of women smokers, compared to non-smokers, that was not apparent in the male or in the total study population.
Positive_regulation (rise) of sP-selectin associated with nicotine addiction
14) Confidence 0.26 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.66 Pain Relevance 0
Serum and plasma were prepared for measurement of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), soluble P-selectin, soluble intracellular adhesion molecule-1 (ICAM-1) and CD40 ligand using commercially available ELISAs (Quantikine, R&D Systems).
Positive_regulation (soluble) of P-selectin in plasma associated with necrosis, cancer and adhesions
15) Confidence 0.14 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2918524 Disease Relevance 0.38 Pain Relevance 0.07
RESULTS: Patients with AMI and UA had higher levels of platelets CD154 and CD62 as compared to those with SA and among patients with AMI, UA and SA versus healthy volunteers.
Positive_regulation (levels) of CD62 in platelets
16) Confidence 0.08 Published 2009 Journal Thromb. Res. Section Body Doc Link 19656553 Disease Relevance 0.16 Pain Relevance 0
In addition, the cell-surface antigen activated leukocyte-cell adhesion molecule, which reacts with the monoclonal antibody SB-10, has been shown to be expressed in undifferentiated cells but is lost during mesenchymal differentiation.
Positive_regulation (activated) of leukocyte-cell adhesion molecule in leukocyte associated with adhesions
17) Confidence 0.06 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154434 Disease Relevance 0.37 Pain Relevance 0
Soluble P-selectin was increased after PTCA and SK lysis up to 8 hours after treatment compared with controls, but no significant differences could be found between treatment groups.


Positive_regulation (increased) of P-selectin associated with percutaneous transluminal coronary angioplasty
18) Confidence 0.05 Published 2001 Journal Crit Care Section Abstract Doc Link PMC31578 Disease Relevance 0.41 Pain Relevance 0.31
We assayed platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31), intercellular adhesion molecule-1 (ICAM-1, CD54), and P-selectin (CD62P) in plasma obtained from 20 patients within 3 h after the onset of acute myocardial infarction (AMI); 16 patients with unstable angina pectoris; 20 patients with stable angina pectoris, and 28 controls.
Positive_regulation (assayed) of CD62P in platelet associated with stable angina pectoris, angina, myocardial infarction and adhesions
19) Confidence 0.05 Published 2003 Journal Int. J. Cardiol. Section Abstract Doc Link 12957760 Disease Relevance 1.72 Pain Relevance 0.65
The aim of the study was to determine whether the levels of soluble P-selectin (sP-selectin) and soluble CD40L (sCD40L) are elevated in Asian Indian subjects with impaired glucose tolerance (IGT), diabetes, and metabolic syndrome (MS).
Spec (whether) Positive_regulation (elevated) of P-selectin associated with diabetes mellitus, tolerance, metabolic syndrome and impaired glucose tolerance
20) Confidence 0.02 Published 2006 Journal Metab. Clin. Exp. Section Abstract Doc Link 16423632 Disease Relevance 1.18 Pain Relevance 0.27

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