INT49802

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.81
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 75
Total Number 75
Disease Relevance 44.74
Pain Relevance 8.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MUC1) plasma membrane (MUC1) nucleus (MUC1)
cytoplasm (MUC1)
Anatomy Link Frequency
epithelial cell 5
goblet cells 4
lung 4
tear 3
mucous cells 3
MUC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Acupuncture 496 99.92 Very High Very High Very High
Inflammation 1256 99.74 Very High Very High Very High
Opioid 9 99.40 Very High Very High Very High
cINOD 75 99.38 Very High Very High Very High
Inflammatory response 124 98.44 Very High Very High Very High
aspirin 108 98.30 Very High Very High Very High
GABAergic 46 98.24 Very High Very High Very High
alcohol 4 98.08 Very High Very High Very High
opioid receptor 3 98.00 Very High Very High Very High
Inflammatory mediators 153 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 379 100.00 Very High Very High Very High
Breast Cancer 78 99.82 Very High Very High Very High
Papillary Adenocarcinoma 12 99.82 Very High Very High Very High
Disease 382 99.76 Very High Very High Very High
INFLAMMATION 1500 99.74 Very High Very High Very High
Stress 65 99.70 Very High Very High Very High
Infection 581 99.60 Very High Very High Very High
Hypersensitivity 301 99.48 Very High Very High Very High
Gallstones 20 99.48 Very High Very High Very High
Apoptosis 434 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The authors are aware that dry eye disease is generally believed to be a disease of reduced mucin secretions.
Localization (secretions) of mucin in eye associated with disease and eye disease
1) Confidence 0.81 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 1.21 Pain Relevance 0
Secretion of gallbladder mucin is an important step in gallstone pathogenesis.
Localization (Secretion) of mucin associated with gallstones
2) Confidence 0.80 Published 1995 Journal Dig. Dis. Sci. Section Abstract Doc Link 7587793 Disease Relevance 0.49 Pain Relevance 0.35
To determine whether MUC1 release can be triggered simply by particulate binding, in the absence of microbial molecular signalling, we used 1 ┬Ám beads coated with either an antibody against the extracellular domain of MUC1 or with an isotype control antibody.
Localization (release) of MUC1
3) Confidence 0.78 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.41 Pain Relevance 0
In the human stomach, the Leb blood-group antigen is mainly expressed by the surface epithelium and on the MUC5AC secreted mucin [11].
Localization (secreted) of mucin in blood
4) Confidence 0.78 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.25 Pain Relevance 0
We now demonstrate that the majority of H. pylori strains can bind to human MUC1 and that release of MUC1 following binding limits adhesion to the cell surface.
Localization (release) of MUC1 associated with sprains and strains and adhesions
5) Confidence 0.78 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2752161 Disease Relevance 1.20 Pain Relevance 0.08
When the pathogen does bind to MUC1, the extracellular domain of the mucin is released from the epithelial surface, thereby acting as a releasable decoy and preventing prolonged adherence.
Localization (released) of mucin
6) Confidence 0.78 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.45 Pain Relevance 0.03
MUC1 acts as a releasable decoy for MUC1-binding bacteria-sized beads
Localization (releasable) of MUC1
7) Confidence 0.73 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.46 Pain Relevance 0
Isolation of MUC1 and assessment of MUC1 glycosylation
Localization (assessment) of MUC1
8) Confidence 0.73 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.06 Pain Relevance 0
These results demonstrate that when inert bacterial sized particles bind to MUC1, the MUC1 extracellular domain is released from the epithelial cell surface.


Localization (released) of MUC1 in epithelial cell
9) Confidence 0.73 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.10 Pain Relevance 0
On the ocular surface, the large secreted gel-forming mucin, human mucin 5AC (MUC5AC), is expressed by the goblet cells and hydrates in the tear film to act as a lubricating agent and clearing molecule [21,22].
Localization (secreted) of mucin in tear
10) Confidence 0.71 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 0 Pain Relevance 0
This inability to detect membrane bound MUC1 because of glycosylation differences is documented in the literature where the presence of MUC1 on hematopoietic cells in patients having certain cancers was ignored for some time [27].
Localization (presence) of MUC1 in hematopoietic cells associated with cancer
11) Confidence 0.71 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 0.85 Pain Relevance 0
Previous studies have demonstrated that aspirin and other nonsteroidal antiinflammatory drugs (NSAIDs) can both inhibit gallbladder mucin secretion and prevent gallstone formation in animal models of cholesterol gallstone disease.
Localization (secretion) of mucin associated with aspirin, inflammation, cinod, disease and gallstones
12) Confidence 0.70 Published 1995 Journal Dig. Dis. Sci. Section Abstract Doc Link 7587793 Disease Relevance 0.62 Pain Relevance 0.45
MUC1 resulted in an anti-MUC1 antibody response which was
Localization (response) of MUC1
13) Confidence 0.70 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC400208 Disease Relevance 0.88 Pain Relevance 0.09
the widely overexpressed breast cancer antigen MUC1 as well as
Localization (well) of MUC1 associated with breast cancer
14) Confidence 0.70 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC400208 Disease Relevance 1.19 Pain Relevance 0.05
The alternative forms of MUC1 and MUC16 lack the cytoplasmic tail portion of the protein and thus are secreted or shed into the tear film, as opposed to being anchored on epithelial cell membranes.
Localization (secreted) of MUC1 in epithelial cell
15) Confidence 0.69 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 0 Pain Relevance 0
Release of MUC1 can occur either by (a) breakdown of the non-covalent association of the ?
Localization (Release) of MUC1
16) Confidence 0.68 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.37 Pain Relevance 0
When the pathogen does bind to MUC1, the extracellular domain of the mucin is released from the epithelial surface, thereby acting as a releasable decoy and preventing prolonged adherence.
Localization (released) of mucin
17) Confidence 0.68 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.85 Pain Relevance 0
However, MMP-14 only partially affected MUC1 shedding during infection and had no influence on MUC1 shedding in non-infected cells, indicating that other factors are involved in MUC1 release.
Localization (release) of MUC1 associated with infection
18) Confidence 0.68 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.17 Pain Relevance 0
Additionally, secreted isoforms of MUC1 expressed via alternative splicing [37], could potentially be shed without prior H. pylori binding and contribute to the MUC1 pool in the mucus and gastric juice.
Localization (secreted) of MUC1 in gastric juice
19) Confidence 0.68 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.13 Pain Relevance 0
However, knockdown of MMP-14 partially affected MUC1 release early in infection, whereas ADAM17 had no effect.
Localization (release) of MUC1 associated with infection
20) Confidence 0.68 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2752161 Disease Relevance 0.75 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox