INT49803

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Context Info
Confidence 0.58
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 37
Total Number 38
Disease Relevance 26.37
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MUC1) plasma membrane (MUC1) nucleus (MUC1)
cytoplasm (MUC1)
Anatomy Link Frequency
epithelial cell 3
eye 2
surface epithelium 2
lung 1
bile 1
MUC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 16 99.46 Very High Very High Very High
Bile 8 97.48 Very High Very High Very High
cytokine 13 95.92 Very High Very High Very High
Acupuncture 62 93.20 High High
aspirin 2 89.12 High High
Inflammation 104 82.80 Quite High
Chronic pancreatitis 15 82.32 Quite High
imagery 8 72.40 Quite High
peptic ulcer disease 88 70.80 Quite High
iatrogenic 1 64.84 Quite High
Disease Link Frequency Relevance Heat
Infection 641 100.00 Very High Very High Very High
Carcinoma 36 100.00 Very High Very High Very High
Gastritis 220 99.96 Very High Very High Very High
Cancer 193 99.90 Very High Very High Very High
Eye Disease 19 99.88 Very High Very High Very High
Nicotine Addiction 400 99.76 Very High Very High Very High
Gallstones 20 99.54 Very High Very High Very High
Necrosis 178 99.50 Very High Very High Very High
Apoptosis 751 99.18 Very High Very High Very High
Pancreatic Cancer 61 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study was performed to determine if chronic NSAID use was associated with a reduction in the mucin content or affected the lipid components of human gallbladder bile.
Negative_regulation (reduction) of mucin in bile associated with bile and cinod
1) Confidence 0.58 Published 1995 Journal Dig. Dis. Sci. Section Abstract Doc Link 7587793 Disease Relevance 0.74 Pain Relevance 0.58
Deficiency of MUC1/Muc1 resulted in increased epithelial cell apoptosis, both in MKN7 cells in vitro, and in H. pylori infected mice.
Negative_regulation (Deficiency) of Muc1 in epithelial cell associated with apoptosis
2) Confidence 0.57 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2752161 Disease Relevance 0.96 Pain Relevance 0.07
Deficiency of MUC1/Muc1 resulted in increased epithelial cell apoptosis, both in MKN7 cells in vitro, and in H. pylori infected mice.
Negative_regulation (Deficiency) of MUC1 in epithelial cell associated with apoptosis
3) Confidence 0.57 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2752161 Disease Relevance 0.96 Pain Relevance 0.07
This pattern is consistent with a loss of beads from the cell surface once the MUC1 binding sites on the beads are filled and/or the MUC1 on the epithelial cell surface is depleted.
Negative_regulation (depleted) of MUC1 in epithelial cell
4) Confidence 0.57 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.17 Pain Relevance 0
Paradoxically, however, necrosis was lower in cells with reduced MUC1.
Negative_regulation (reduced) of MUC1 associated with necrosis
5) Confidence 0.57 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 1.02 Pain Relevance 0
Four patients (#11, 13, 16, 20) received long-term sivelestat and displayed significant downregulation of NAMPT and MUC1 mRNA (p < 0.001 and 0.034 by one-way ANOVA) compared with the 23 patients who did not receive this medication.
Negative_regulation (downregulation) of MUC1
6) Confidence 0.47 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.89 Pain Relevance 0.12
Mucins have been implicated in the pathophysiology of dry eye disease, but mucin deficiency is no longer described as a separate class of dry eye [31].
Negative_regulation (deficiency) of mucin in eye associated with dry eye and eye disease
7) Confidence 0.43 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 1.04 Pain Relevance 0
The rapid decrease in MUC1 protein with sustained levels of MUC1 mRNA, suggest that loss of protein rather than decreased MUC1 production is the likely explanation for MUC1 depletion from the cell.
Negative_regulation (decrease) of MUC1
8) Confidence 0.42 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.06 Pain Relevance 0
In an experiment to evaluate the importance of MUC1 in H. pylori induced apoptosis, transfection of siRNAs into MKN7 cells reduced MUC1 levels by 93% and 97% with the 1?
Negative_regulation (reduced) of MUC1 associated with apoptosis
9) Confidence 0.42 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 1.55 Pain Relevance 0
Our demonstration of progressive depletion of cellular MUC1 is consistent with a previous study where MUC1 expression decreased in Kato III cells after 4 h of co-culture with H. pylori (with unknown adhesion properties) [33].
Negative_regulation (depletion) of MUC1 associated with adhesions
10) Confidence 0.42 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.28 Pain Relevance 0
We have shown that mice deficient in Muc1 are more susceptible to infection by both H. pylori [20] and Campylobacter jejuni [21].
Negative_regulation (deficient) of Muc1 associated with infection
11) Confidence 0.42 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.38 Pain Relevance 0
After 30 min of co-culture, binding of J99 (both with and without the SabA and BabA adhesins) to MKN7 cells was higher when MUC1 was depleted by siRNA (Figure 7B).
Negative_regulation (depleted) of MUC1
12) Confidence 0.42 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.53 Pain Relevance 0
To explore whether H. pylori SabA or BabA adhesin mediated binding to MUC1 was required for depletion of MUC1 we used the J99?
Spec (whether) Negative_regulation (depletion) of MUC1
13) Confidence 0.42 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.17 Pain Relevance 0
Previously we have shown that mice deficient in Muc1 are more susceptible to infection by H. pylori [20] both with regard to the level of colonisation and the degree of pathology that develops.
Negative_regulation (deficient) of Muc1 associated with infection
14) Confidence 0.42 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 1.18 Pain Relevance 0
In cultured MKN7 cells we observed a progressive depletion of MUC1 as it was shed off the cell surface.
Negative_regulation (depletion) of MUC1
15) Confidence 0.42 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.62 Pain Relevance 0
In human patients with chronic gastritis, depletion of the MUC1 extracellular domain ?
Negative_regulation (depletion) of MUC1 associated with gastritis
16) Confidence 0.42 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.57 Pain Relevance 0
However, the proportion of necrotic cells was slightly lower in the cells with reduced MUC1.
Negative_regulation (reduced) of MUC1
17) Confidence 0.42 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 1.39 Pain Relevance 0
The rapid decrease in MUC1 protein with sustained levels of MUC1 mRNA, suggest that loss of protein rather than decreased MUC1 production is the likely explanation for MUC1 depletion from the cell.
Negative_regulation (depletion) of MUC1
18) Confidence 0.42 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.11 Pain Relevance 0
A single J99 SabA deletion mutant resulted in a small non-significant decrease in MUC1 binding and a single J99 BabA deletion mutant showed intermediate MUC1 binding (Figure 2B).
Negative_regulation (decrease) of MUC1
19) Confidence 0.41 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.34 Pain Relevance 0
Cellular MUC1 decreased with infection at 24 h and free MUC1 in the culture medium also decreased at 8 h which is consistent with other experiments (presented as the proportion of uninfected controls for all siRNA conditions in Figure 6C and D, respectively).
Negative_regulation (decreased) of MUC1 associated with infection
20) Confidence 0.41 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.39 Pain Relevance 0

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