INT49804

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Context Info
Confidence 0.59
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.84
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MUC1) plasma membrane (MUC1) nucleus (MUC1)
cytoplasm (MUC1)
Anatomy Link Frequency
eye 2
tears 2
tracheal epithelial cells 2
goblet cell 2
MUC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 8 99.78 Very High Very High Very High
aspirin 1 98.70 Very High Very High Very High
Acupuncture 124 96.00 Very High Very High Very High
cytokine 64 94.20 High High
Inflammation 143 85.56 High High
Bile 4 79.44 Quite High
antagonist 1 51.92 Quite High
Inflammatory mediators 25 26.48 Quite Low
anesthesia 4 5.20 Low Low
chemokine 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 18 99.92 Very High Very High Very High
Syndrome 101 99.84 Very High Very High Very High
INFLAMMATION 178 99.50 Very High Very High Very High
Gallstones 10 99.48 Very High Very High Very High
Eye Disease 19 99.16 Very High Very High Very High
Nicotine Addiction 133 98.94 Very High Very High Very High
Pulmonary Disease 73 97.88 Very High Very High Very High
Hyperplasia 11 96.08 Very High Very High Very High
Sjoegrens Syndrome 57 93.64 High High
Respiratory Disease 22 89.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The authors are aware that dry eye disease is generally believed to be a disease of reduced mucin secretions.
Negative_regulation (reduced) of Localization (secretions) of mucin in eye associated with disease and eye disease
1) Confidence 0.59 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 1.21 Pain Relevance 0
Previous studies have demonstrated that aspirin and other nonsteroidal antiinflammatory drugs (NSAIDs) can both inhibit gallbladder mucin secretion and prevent gallstone formation in animal models of cholesterol gallstone disease.
Negative_regulation (inhibit) of Localization (secretion) of mucin associated with aspirin, inflammation, cinod, disease and gallstones
2) Confidence 0.51 Published 1995 Journal Dig. Dis. Sci. Section Abstract Doc Link 7587793 Disease Relevance 0.62 Pain Relevance 0.45
Certainly, the secreted mucin MUC5AC has been shown to be reduced in SS tears and conjunctival cells [29].
Negative_regulation (reduced) of Localization (secreted) of mucin in tears associated with syndrome
3) Confidence 0.44 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2613075 Disease Relevance 1.28 Pain Relevance 0
Furthermore, the pathways for inhibiting the mucin secretion should be clarified in our next experiments.
Negative_regulation (inhibiting) of Localization (secretion) of mucin
4) Confidence 0.09 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1397865 Disease Relevance 0.08 Pain Relevance 0.24
The observed decrease in mucin stores in long-term ex-smokers with COPD, and its relation with duration of smoking cessation, can be explained by decreased goblet cell numbers, decreased mucin production, and/or increased mucin secretion.
Negative_regulation (decreased) of Localization (secretion) of mucin in goblet cell associated with pulmonary disease and nicotine addiction
5) Confidence 0.07 Published 2007 Journal Respir Res Section Body Doc Link PMC2214729 Disease Relevance 1.69 Pain Relevance 0.03
The primary mechanism may be that the facilitation of TMV partly results from the decrease of the mucin secreted from the airway.
Negative_regulation (decrease) of Localization (secreted) of mucin
6) Confidence 0.07 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1397865 Disease Relevance 0.09 Pain Relevance 0.22
Studies have demonstrated that inhibition of intracellular NO production blocks the hypersecretion of mucin in guinea pig tracheal epithelial cells stimulated by reactive oxygen species, TNF-?
Negative_regulation (blocks) of Localization (hypersecretion) of mucin in tracheal epithelial cells
7) Confidence 0.01 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 0.87 Pain Relevance 0.24

General Comments

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