INT49805

Context Info Confidence 0.70 First Reported 1993 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 56 Total Number 56 Disease Relevance 44.50 Pain Relevance 4.56

extracellular region (MUC1) plasma membrane (MUC1) nucleus (MUC1) cytoplasm (MUC1)

Anatomy Link Frequency tear 4 epithelial cells 3 lung 3 sensory neurons 2 smooth muscle 2 MUC1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 655 99.72 Nicotine 9 99.50 Bile 4 99.12 Inflammatory mediators 69 98.64 Inflammatory marker 5 98.44 antagonist 7 93.12 cINOD 42 92.64 gABA 59 91.28 agonist 20 90.88 GABAergic 46 90.12

Disease Link Frequency Relevance Heat Nervous System Paraneoplastic Syndromes 16 100.00 Syndrome 472 99.88 Nicotine Addiction 303 99.84 Airway Remodeling 18 99.78 INFLAMMATION 766 99.72 Metaplasia 73 99.70 Sjoegrens Syndrome 279 99.64 Cancer 352 99.50 Dry Eye 207 99.48 Hypersensitivity 212 99.46

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

KCS subjects demonstrated increased levels of soluble MUC1 compared to NDE.

Positive_regulation (increased) of MUC1 associated with sjoegrens syndrome and dry eye

1) Confidence 0.70 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 1.70 Pain Relevance 0

The KCS group also demonstrated increased concentrations of soluble MUC1 in the tear film compared with NDE subjects.

Positive_regulation (increased) of MUC1 in tear associated with sjoegrens syndrome and dry eye

2) Confidence 0.70 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 1.23 Pain Relevance 0

Our findings would suggest that this compensatory or protective mechanism is most prevalent in SS dry eye disease, but may be related to disease severity, as suggested by the increased soluble MUC1 seen in KCS subjects over NDE subjects in our results.

Positive_regulation (increased) of MUC1 in eye associated with sjoegrens syndrome, syndrome, dry eye, disease and eye disease

3) Confidence 0.70 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 1.34 Pain Relevance 0.03

These results, combined with our previous work with MUC16 [30], demonstrate an excess of both MUC1 and MUC16 in the tear film of SS subjects and increased levels of mRNA for these mucins in conjunctival cells.

Positive_regulation (excess) of MUC1 in tear associated with syndrome

4) Confidence 0.70 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 0.74 Pain Relevance 0

We found that Sjogren’s subjects express significantly elevated concentrations of both soluble MUC1 and MUC1 mRNA compared to both KCS and NDE groups.

Positive_regulation (elevated) of MUC1 associated with sjoegrens syndrome and dry eye

5) Confidence 0.70 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 1.26 Pain Relevance 0

We found that Sjogren’s subjects express significantly elevated concentrations of both soluble MUC1 and MUC1 mRNA compared to both KCS and NDE groups.

Positive_regulation (elevated) of MUC1 associated with sjoegrens syndrome and dry eye

6) Confidence 0.70 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 1.26 Pain Relevance 0

This increased mucin activity in the early stages of the keratinisation process, or during inflammation, suggests that ocular surface cells can participate in compensatory attempts to synthesize more mucin to maintain a wet surface phenotype or to protect themselves in other ways.

Positive_regulation (increased) of mucin associated with inflammation

7) Confidence 0.70 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 0.83 Pain Relevance 0.09

However, there were significant increases in the amount of shed MUC1 following knockdown of MMP-14 at 8 but not 24 h of infection, although no changes were seen following knockdown of ADAM17 (Figure 6D).

Positive_regulation (increases) of MUC1 associated with infection

8) Confidence 0.68 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.32 Pain Relevance 0

Tumor cells in the epithelial layer were negative for periodic acid Schiff (PAS) and alcian blue, but partly positive for epithelial membrane antigen (EMA) and CEA, whereas those in the submucosal ducts and glands were strongly positive for PAS, alcian blue, carcinoembryonic antigen, and EMA, especially at their luminal surfaces.

Positive_regulation (positive) of EMA in glands associated with cancer

9) Confidence 0.66 Published 1993 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 8385166 Disease Relevance 1.20 Pain Relevance 0.06

MUC1 and PDGFA were upregulated at POD 3 (p = 0.048 and 0.045), followed by recovery from POD 5 to POD 14.

Positive_regulation (upregulated) of MUC1

10) Confidence 0.55 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.25 Pain Relevance 0.03

A single J99 SabA deletion mutant resulted in a small non-significant decrease in MUC1 binding and a single J99 BabA deletion mutant showed intermediate MUC1 binding (Figure 2B).

Positive_regulation (intermediate) of MUC1

11) Confidence 0.49 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.39 Pain Relevance 0

Immunohistochemically, the neoplastic cells were positive for S-100 protein (diffuse and strong), CD34 (primarily in Antoni B areas), glial fibrillary acidic protein (GFAP; weak and diffuse) and calretinin (mainly in Antoni A areas), while none was positive for CD31, estrogen and progesterone receptors, bcl-2, or epithelial membrane antigen (EMA).

Positive_regulation (positive) of EMA

12) Confidence 0.49 Published 2005 Journal Pathol. Int. Section Abstract Doc Link 15998381 Disease Relevance 0.93 Pain Relevance 0.10

By IMHC, the cells were positive for inhibin, melan-A, and synaptophysin, and negative for GFAP, EMA, cytokeratins, S-100, HMB-45, and chromogranin.

Positive_regulation (negative) of EMA

13) Confidence 0.49 Published 2004 Journal Int. J. Surg. Pathol. Section Abstract Doc Link 15306940 Disease Relevance 0.89 Pain Relevance 0.15

The results of this study demonstrate that subjects with confirmed Sjogren’s syndrome have increased levels of soluble MUC1 in their tear film and MUC1 mRNA in their conjunctival epithelial cells compared to both KCS and non dry eye (NDE) subjects and that SS subjects have increased levels of membrane bound MUC1 compared to NDE subjects.

Positive_regulation (increased) of MUC1 in tear associated with sjoegrens syndrome, syndrome and dry eye

14) Confidence 0.47 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 2.09 Pain Relevance 0

Antibody responses to MUC1

Positive_regulation (responses) of MUC1

15) Confidence 0.47 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC400208 Disease Relevance 0.40 Pain Relevance 0

Cellular immune response to MUC1

Positive_regulation (response) of MUC1

16) Confidence 0.47 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC400208 Disease Relevance 0.13 Pain Relevance 0

However, MUC1 mRNA levels increased progressively in culture but were not significantly affected by the presence of H. pylori (Figure 5B).

Neg (not) Positive_regulation (increased) of MUC1

17) Confidence 0.45 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.12 Pain Relevance 0

Patients with gallstones had a significantly (P < 0.02) greater concentration of gallbladder mucin in their gallbladder bile compared to patients without gallstones (0.897 +/- 0.226 vs 0.173 +/- 0.039 mg/ml).

Positive_regulation (concentration) of mucin in bile associated with bile and gallstones

18) Confidence 0.44 Published 1995 Journal Dig. Dis. Sci. Section Abstract Doc Link 7587793 Disease Relevance 0.99 Pain Relevance 0.82

The results of this study demonstrate that subjects with confirmed Sjogren’s syndrome have increased levels of soluble MUC1 in their tear film and MUC1 mRNA in their conjunctival epithelial cells compared to both KCS and non dry eye (NDE) subjects and that SS subjects have increased levels of membrane bound MUC1 compared to NDE subjects.

Positive_regulation (increased) of MUC1 in tear associated with sjoegrens syndrome, syndrome and dry eye

19) Confidence 0.41 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2927371 Disease Relevance 2.08 Pain Relevance 0

The carcinoma cells in all cases (14 cases) of PIDC were diffusely positive for MUC1, 45M1, p53 and Ki67, and focally positive for MUC6.

Positive_regulation (positive) of MUC1 associated with carcinoma

20) Confidence 0.40 Published 2005 Journal J Carcinog Section Body Doc Link PMC1185555 Disease Relevance 1.00 Pain Relevance 0.08

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