INT49805
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
KCS subjects demonstrated increased levels of soluble MUC1 compared to NDE. | |||||||||||||||
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The KCS group also demonstrated increased concentrations of soluble MUC1 in the tear film compared with NDE subjects. | |||||||||||||||
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Our findings would suggest that this compensatory or protective mechanism is most prevalent in SS dry eye disease, but may be related to disease severity, as suggested by the increased soluble MUC1 seen in KCS subjects over NDE subjects in our results. | |||||||||||||||
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These results, combined with our previous work with MUC16 [30], demonstrate an excess of both MUC1 and MUC16 in the tear film of SS subjects and increased levels of mRNA for these mucins in conjunctival cells. | |||||||||||||||
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We found that Sjogrens subjects express significantly elevated concentrations of both soluble MUC1 and MUC1 mRNA compared to both KCS and NDE groups. | |||||||||||||||
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We found that Sjogrens subjects express significantly elevated concentrations of both soluble MUC1 and MUC1 mRNA compared to both KCS and NDE groups. | |||||||||||||||
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This increased mucin activity in the early stages of the keratinisation process, or during inflammation, suggests that ocular surface cells can participate in compensatory attempts to synthesize more mucin to maintain a wet surface phenotype or to protect themselves in other ways. | |||||||||||||||
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However, there were significant increases in the amount of shed MUC1 following knockdown of MMP-14 at 8 but not 24 h of infection, although no changes were seen following knockdown of ADAM17 (Figure 6D). | |||||||||||||||
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Tumor cells in the epithelial layer were negative for periodic acid Schiff (PAS) and alcian blue, but partly positive for epithelial membrane antigen (EMA) and CEA, whereas those in the submucosal ducts and glands were strongly positive for PAS, alcian blue, carcinoembryonic antigen, and EMA, especially at their luminal surfaces. | |||||||||||||||
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MUC1 and PDGFA were upregulated at POD 3 (p = 0.048 and 0.045), followed by recovery from POD 5 to POD 14. | |||||||||||||||
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A single J99 SabA deletion mutant resulted in a small non-significant decrease in MUC1 binding and a single J99 BabA deletion mutant showed intermediate MUC1 binding (Figure 2B). | |||||||||||||||
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Immunohistochemically, the neoplastic cells were positive for S-100 protein (diffuse and strong), CD34 (primarily in Antoni B areas), glial fibrillary acidic protein (GFAP; weak and diffuse) and calretinin (mainly in Antoni A areas), while none was positive for CD31, estrogen and progesterone receptors, bcl-2, or epithelial membrane antigen (EMA). | |||||||||||||||
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By IMHC, the cells were positive for inhibin, melan-A, and synaptophysin, and negative for GFAP, EMA, cytokeratins, S-100, HMB-45, and chromogranin. | |||||||||||||||
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The results of this study demonstrate that subjects with confirmed Sjogrens syndrome have increased levels of soluble MUC1 in their tear film and MUC1 mRNA in their conjunctival epithelial cells compared to both KCS and non dry eye (NDE) subjects and that SS subjects have increased levels of membrane bound MUC1 compared to NDE subjects. | |||||||||||||||
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Antibody responses to MUC1 | |||||||||||||||
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Cellular immune response to MUC1 | |||||||||||||||
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However, MUC1 mRNA levels increased progressively in culture but were not significantly affected by the presence of H. pylori (Figure 5B). | |||||||||||||||
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Patients with gallstones had a significantly (P < 0.02) greater concentration of gallbladder mucin in their gallbladder bile compared to patients without gallstones (0.897 +/- 0.226 vs 0.173 +/- 0.039 mg/ml). | |||||||||||||||
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The results of this study demonstrate that subjects with confirmed Sjogrens syndrome have increased levels of soluble MUC1 in their tear film and MUC1 mRNA in their conjunctival epithelial cells compared to both KCS and non dry eye (NDE) subjects and that SS subjects have increased levels of membrane bound MUC1 compared to NDE subjects. | |||||||||||||||
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The carcinoma cells in all cases (14 cases) of PIDC were diffusely positive for MUC1, 45M1, p53 and Ki67, and focally positive for MUC6. | |||||||||||||||
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