INT49808

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Context Info
Confidence 0.78
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 8.74
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
mast cell 5
extracellular matrix 2
urinary bladder 1
plasma 1
fibroblast 1
tryptase (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 220 99.12 Very High Very High Very High
substance P 23 98.44 Very High Very High Very High
nud 30 98.34 Very High Very High Very High
interstitial cystitis 6 97.80 Very High Very High Very High
Pain 9 97.32 Very High Very High Very High
peptic ulcer disease 2 95.04 Very High Very High Very High
Spinal cord 1 92.04 High High
cytokine 30 86.00 High High
agonist 9 85.88 High High
Inflammatory mediators 2 82.72 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 269 99.12 Very High Very High Very High
Dyspepsia 30 98.34 Very High Very High Very High
Interstitial Cystitis 6 97.80 Very High Very High Very High
Microphthalmia 23 97.48 Very High Very High Very High
Edema 38 97.36 Very High Very High Very High
Pain 7 97.32 Very High Very High Very High
Anaphylaxis 58 97.04 Very High Very High Very High
Neurogenic Inflammation 2 96.24 Very High Very High Very High
Hypersensitivity 7 95.56 Very High Very High Very High
Ulcers 23 95.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tryptase, a serine protease released from mast cell secretory granules, is found at elevated levels in pathophysiologic conditions associated with allergic inflammation.
Localization (released) of Tryptase in mast cell associated with inflammation and hypersensitivity
1) Confidence 0.78 Published 1997 Journal Expert Opin Investig Drugs Section Abstract Doc Link 15989643 Disease Relevance 0.62 Pain Relevance 0.20
We here ascertain whether tryptase (a serine endoprotease released by mast cells) and cathepsin D (CD, a lysosomal hydrolase that seems able to derange the extracellular matrix) play a part in peptic ulcer disease and whether they are linked to Helicobacter pylori (Hp) infection.
Localization (released) of tryptase in extracellular matrix associated with peptic ulcer disease, ulcers, disease and infection
2) Confidence 0.32 Published 1995 Journal Dig. Dis. Sci. Section Abstract Doc Link 7587835 Disease Relevance 1.09 Pain Relevance 0.09
We investigated whether tryptase (a serine endoprotease released by mast cells) and cathepsin D (a lysosomal hydrolase which seems able to derange the extracellular matrix) play a part in peptic ulcer disease and whether they are linked to Helicobacter pylori infection and mucosal content of gastrin.
Localization (released) of tryptase in extracellular matrix associated with peptic ulcer disease, ulcers, disease and infection
3) Confidence 0.30 Published 1994 Journal Res Exp Med (Berl) Section Abstract Doc Link 8202635 Disease Relevance 1.22 Pain Relevance 0.10
All sections were blocked in PBS, 5% goat serum albumin (blocking buffer) for 20 min, and staining was performed with the following primary antibodies at the given dilution in blocking buffer (1 hour, room temperature): mouse monoclonal antibodies against CXCR1 (Clone 42705.111, 1:40; R&D Systems, Minneapolis, MN, USA), CXCR2 (Clone 48311.211, 1:10; R&D), CXCR3 (Clone 49801.111, 1:100; R&D), MC tryptase (Clone AA1, 1:50; Dako, Hamburg, Germany), CD68 (Clone KP1, 1:80; Dako), fibroblast prolyl-4-hydroxylase (Clone 5B5, 1:10; Dako), and CD3 (Clone F7.2.38, 1:50; Dako).
Localization (1:80) of tryptase in fibroblast
4) Confidence 0.25 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.10 Pain Relevance 0.05
The possible mechanisms by which LPS and SP induce PAR activation include degranulation of mast cells with a concomitant release of tryptase and plasma extravasation leading to accumulation of products of the coagulation cascade that activate PARs.
Localization (release) of tryptase in plasma associated with substance p
5) Confidence 0.25 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.50 Pain Relevance 0.26
Increased mast cell numbers and tryptase release represent one of the prevalent etiologic theories for interstitial cystitis and other urinary bladder inflammatory conditions.
Localization (release) of tryptase in urinary bladder associated with inflammation and interstitial cystitis
6) Confidence 0.20 Published 2007 Journal BMC Physiol Section Abstract Doc Link PMC1853108 Disease Relevance 0.75 Pain Relevance 0.38
CCRL2 expression by tissue mast cells may serve to coat the cells with the proform of chemerin, which would be immediately activated upon mast cell degranulation and tryptase release (27).
Localization (release) of tryptase in mast cell
7) Confidence 0.18 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.83 Pain Relevance 0.03
These represent a novel mechanism through which trypsin or tryptase released in response to tissue inflammation might trigger the sensation of pain by PAR2 activation.
Localization (released) of tryptase associated with pain and inflammation
8) Confidence 0.16 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15128843 Disease Relevance 0.40 Pain Relevance 0.54
In our previous studies, we showed that pro-chemerin is rapidly activated by extracellular serine proteases such as secreted mast cell tryptase (27).
Localization (secreted) of tryptase in mast cell
9) Confidence 0.15 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556791 Disease Relevance 0.85 Pain Relevance 0.03
To the best of our knowledge, this is the first report describing TFEB expression in response to PAR activation in the bladder and suggest a unifying, mechanistic pathway of bladder inflammation as follows: we hypothesize that mast cells release tryptase resulting in increased PAR activation and, consequently, TFEB/MiTF activity.
Localization (release) of tryptase in mast cells associated with inflammation and microphthalmia
10) Confidence 0.04 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.75 Pain Relevance 0.29
In a study from Shanghai, 550 patients with acute gastrointestinal infection were followed-up for half a year, and the prevalence of PI-FD was estimated to be 6.7% and epigastric pain, epigastric burning sensation, and early satiety were the major symptoms in these patients.26 In gastric biopsies from PI-FD patients, the number of activated mast cells, as evidenced by the total amount of tryptase and histamine released in the gastric mucosa, was reported to be higher than non-PI-FD patients and healthy controls.
Localization (released) of tryptase in mast cells associated with nud and infection
11) Confidence 0.03 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2879823 Disease Relevance 1.58 Pain Relevance 0.71

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