INT49813

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Context Info
Confidence 0.49
First Reported 1995
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 2.80
Pain Relevance 2.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 1
Ptz1a (Mus musculus)
Pain Link Frequency Relevance Heat
Gabapentin 40 99.64 Very High Very High Very High
anticonvulsant 40 99.16 Very High Very High Very High
GABAergic 65 99.04 Very High Very High Very High
opiate 3 97.04 Very High Very High Very High
withdrawal 17 96.76 Very High Very High Very High
Morphine 5 96.04 Very High Very High Very High
antiepileptic Drug 20 96.00 Very High Very High Very High
gABA 154 95.04 Very High Very High Very High
Action potential 3 90.36 High High
Glutamate receptor 9 89.52 High High
Disease Link Frequency Relevance Heat
Convulsion 117 100.00 Very High Very High Very High
Epilepsy 33 97.16 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 21 94.32 High High
Disease 6 92.36 High High
Heart Rate Under Development 2 87.16 High High
Death 16 83.96 Quite High
Myoclonus 6 70.96 Quite High
Disseminated Intravascular Coagulation 3 70.72 Quite High
Appetite Loss 1 67.60 Quite High
Decapitation 2 66.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pentylenetetrazol (PTZ) and sodium valproate (VPA) produce acutely in the naive rat various behavioural effects resembling signs of opiate withdrawal in the morphine-treated subject.
Gene_expression (produce) of PTZ associated with opiate, withdrawal and morphine
1) Confidence 0.49 Published 1995 Journal Drug Alcohol Depend Section Abstract Doc Link 7587968 Disease Relevance 0.07 Pain Relevance 0.51
Diazepam was dissolved in vehicle (0.5% Tween 80 and saline), whereas gabapentin, vigabatrin, and PTZ were dissolved in saline.


Gene_expression (dissolved) of PTZ associated with gabapentin
2) Confidence 0.18 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2526378 Disease Relevance 0.54 Pain Relevance 0.46
Preliminary experiments from our group indicated that a single administration of diazepam, gabapentin, or vigabatrin, at the doses and routes described above, was able to reduce PTZ-induced seizures and Fos expression in the mouse brain.
Gene_expression (expression) of PTZ in brain associated with convulsion and gabapentin
3) Confidence 0.16 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2526378 Disease Relevance 0.41 Pain Relevance 0.36
DISCUSSION: It is concluded that dependence on morphine enhances PTZ-induced plastic and epileptic changes in CA1 excitability.
Gene_expression (excitability) of PTZ
4) Confidence 0.06 Published 2009 Journal Epilepsia Section Body Doc Link 19183220 Disease Relevance 0 Pain Relevance 0
Among which, PTZ has been reported to produce seizures by inhibiting GABAergic neurotransmission [30].
Gene_expression (produce) of PTZ associated with convulsion and gabaergic
5) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2560999 Disease Relevance 0.55 Pain Relevance 0.40
PTZ seizures test
Gene_expression (seizures) of PTZ associated with convulsion
6) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2560999 Disease Relevance 0.50 Pain Relevance 0.30
As shown in Fig. 5, clonic and tonic seizures were observed in mice within 30 min after PTZ injection.
Gene_expression (injection) of PTZ associated with convulsion
7) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2560999 Disease Relevance 0.74 Pain Relevance 0.35

General Comments

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