INT49825

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Context Info
Confidence 0.66
First Reported 1995
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 4.87
Pain Relevance 0.87

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oxidoreductase activity (reductase)
Anatomy Mention Frequency
capsule 1
reductase (Caenorhabditis elegans)
Pain Term Frequency Confidence Heat
Morphine 3 100.00 Very High Very High Very High
Codeine 4 100.00 Very High Very High Very High
Angina 1 99.38 Very High Very High Very High
methotrexate 16 98.68 Very High Very High Very High
Calcium channel 2 97.44 Very High Very High Very High
Dopamine 6 89.08 High High
Serotonin 6 83.52 Quite High
cytokine 21 79.76 Quite High
Nicotine 1 72.80 Quite High
Parenteral administration 1 39.12 Quite Low
Disease Term Frequency Confidence Heat
Sprains And Strains 340 99.64 Very High Very High Very High
Disease 76 99.48 Very High Very High Very High
Cv General 3 Under Development 1 99.38 Very High Very High Very High
Spasticity 1 98.86 Very High Very High Very High
Hypertension 13 98.42 Very High Very High Very High
Anxiety Disorder 7 97.84 Very High Very High Very High
[[ /

[[]]]]

17 97.48 Very High Very High Very High
Syndrome 10 96.96 Very High Very High Very High
Chronic Renal Failure 1 92.56 High High
Urinary Tract Infection 234 90.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, codeinone reductase, a representative of the specific enzyme system in morphine biosynthesis, could be detected within the cytosolic serum fraction.
Gene_expression (detected) of reductase associated with morphine
1) Confidence 0.66 Published 2000 Journal Electrophoresis Section Abstract Doc Link 11079569 Disease Relevance 0 Pain Relevance 0.10
Using capsule tissue of differentiated P. somniferum plants as an enzyme source, two codeinone reductase (NADPH) isoenzymes were detected and purified to homogeneity.
Gene_expression (detected) of reductase in capsule
2) Confidence 0.13 Published 1995 Journal Eur. J. Biochem. Section Abstract Doc Link 7588736 Disease Relevance 0 Pain Relevance 0.06
Codeinone reductase (NADPH), which catalyzes the stereospecific reduction of (-)codeinone to (-)codeine, was detected and purified to electrophoretic homogeneity from a cytosolic fraction of Papaver somniferum L. cell cultures.
Gene_expression (detected) of reductase associated with codeine
3) Confidence 0.13 Published 1995 Journal Eur. J. Biochem. Section Abstract Doc Link 7588736 Disease Relevance 0 Pain Relevance 0.10
Concentration of digoxin, a modulator of amino acid transport, and the activity of HMG CoA reductase, which synthesizes digoxin, were higher in these patients; while RBC membrane Na+-K+ ATPase activity showed a decrease.
Gene_expression (synthesizes) of reductase
4) Confidence 0.05 Published 2000 Journal Neurol India Section Abstract Doc Link 11025626 Disease Relevance 0 Pain Relevance 0.20
In particular, the single-pill combination of atorvastatin and amlodipine (Caduet®, Pfizer, Inc) has provided a unique opportunity to explore the issue of adherence in individuals with both hypertension and dyslipidemia.36 Amlodipine besylate is a dihydropyidine calcium channel blocker (CCB) used for treatment of hypertension and both vaso-spastic and chronic stable angina.37 Atorvastatin is a HMG-Co-A reductase inhibitor that has been shown to be an effective and safe treatment for dyslipidemia and is also effective in reducing the rate of coronary events and revascularization procedure in patients with multiple cardiovascular risk factors.38,39
Gene_expression (inhibitor) of reductase associated with angina, spasticity, calcium channel and hypertension
5) Confidence 0.04 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778438 Disease Relevance 0.39 Pain Relevance 0.15
One particularly well-known example is the Escherichia coli transcription factor OxyR that contains two conserved cysteines that form a disulfide in response to slight elevations in H2O2, which alters its DNA binding site and induces expression of, among other genes, glutathione reductase and glutaredoxin [22].
Gene_expression (expression) of reductase
6) Confidence 0.03 Published 2010 Journal Biol Trace Elem Res Section Body Doc Link PMC2855032 Disease Relevance 0 Pain Relevance 0
The levels of serum digoxin, HMG CoA reductase activity, and dolichol were found to be decreased in OCD and la Tourette's syndrome as well as in left hemispheric dominant individuals with a corresponding increase in RBC Na(+)-K+ ATPase activity, serum ubiquinone, and magnesium levels.
Gene_expression (levels) of reductase associated with syndrome and anxiety disorder
7) Confidence 0.02 Published 2002 Journal Int. J. Neurosci. Section Abstract Doc Link 12424821 Disease Relevance 0.71 Pain Relevance 0
Preliminary evidence for M. ulcerans in environmental samples was obtained from PCR detection of the insertion sequence IS2404 [10] along with PCR detection of the enoyl reductase (ER) domain of the mycolactone toxin [26].
Gene_expression (detection) of reductase
8) Confidence 0.01 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2268743 Disease Relevance 0.07 Pain Relevance 0
CYP6A1, which is overproduced in insecticide-resistant strains, cytochrome P450 reductase, and cytochrome b5 have been cloned from the house fly, Musca domestica, and expressed in Escherichia coli.
Gene_expression (expressed) of reductase associated with sprains and strains
9) Confidence 0.01 Published 2002 Journal J Insect Sci Section Body Doc Link PMC405832 Disease Relevance 0.10 Pain Relevance 0
Using mass spectrometry methods, we demonstrated that numerous proteins involved in the citric acid cycle (isocitrate dehydrogenase, aspartate aminotransferase, malate dehydrogenase, and oxoglutarate dehydrogenase) and electron transport (cytochrome c oxidase, ubiquinol-cytochrome c reductase, NADH dehydrogenase, and ATP synthase) were expressed at lower levels in OS compared with YS subjects.
Gene_expression (expressed) of reductase
10) Confidence 0.01 Published 2008 Journal Diabetes Section Body Doc Link PMC2570389 Disease Relevance 0.08 Pain Relevance 0
MTX is a folic acid analog that inactivates the enzyme dihydrofolate reductase and thus the production of thymidylate, which is essential for DNA replication.
Gene_expression (production) of reductase associated with methotrexate
11) Confidence 0.01 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2893757 Disease Relevance 0.86 Pain Relevance 0.26
Interestingly, the three patient isolates that only weakly expressed cyoABCDE also expressed nitrate reductase, formate dehydrogenase N, and nitrite reductase, suggesting that these isolates likely experienced a more anaerobic and nitrate/nitrite-rich environment and may be using these products for anaerobic respiration.
Gene_expression (expressed) of reductase
12) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2978726 Disease Relevance 0.67 Pain Relevance 0
Interestingly, the three patient isolates that only weakly expressed cyoABCDE also expressed nitrate reductase, formate dehydrogenase N, and nitrite reductase, suggesting that these isolates likely experienced a more anaerobic and nitrate/nitrite-rich environment and may be using these products for anaerobic respiration.
Gene_expression (expressed) of reductase
13) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2978726 Disease Relevance 0.67 Pain Relevance 0
For example, the genes encoding nitrate reductase I, narGHJIK, were only expressed in vivo by two strains, AL121 and AL151.
Gene_expression (expressed) of reductase associated with sprains and strains
14) Confidence 0.01 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2978726 Disease Relevance 0.89 Pain Relevance 0

General Comments

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