INT4984

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Context Info
Confidence 0.50
First Reported 1992
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 5.34
Pain Relevance 8.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tac1) extracellular region (Tac1) plasma membrane (Tac1)
Anatomy Link Frequency
neurons 4
spinal cord neurons 4
spinal 2
leukocyte 2
nerve 2
Tac1 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 59 100.00 Very High Very High Very High
nMDA receptor 11 100.00 Very High Very High Very High
Spinal cord 15 99.82 Very High Very High Very High
long-term potentiation 43 99.80 Very High Very High Very High
Dorsal horn neuron 23 99.80 Very High Very High Very High
Hyperalgesia 7 99.76 Very High Very High Very High
Dorsal horn 9 99.56 Very High Very High Very High
Stimulus evoked pain 12 98.88 Very High Very High Very High
Pain 44 98.78 Very High Very High Very High
Inflammation 20 98.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 8 99.76 Very High Very High Very High
Pressure And Volume Under Development 5 99.60 Very High Very High Very High
Inflammatory Pain 6 99.40 Very High Very High Very High
Nervous System Injury 6 98.88 Very High Very High Very High
Hypersensitivity 18 98.68 Very High Very High Very High
Nociception 15 98.32 Very High Very High Very High
INFLAMMATION 16 95.44 Very High Very High Very High
Ganglion Cysts 7 94.52 High High
Pain 62 90.00 High High
Neuropathic Pain 13 83.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results support the idea that substance P is an important mediator of thermal hypersensitivity in the setting of nerve injury and suggest that increased NK-1 receptor transcription precedes increased NK-1 receptor density, ultimately leading to behavioral hypersensitivity to peripheral thermal stimulation.
Positive_regulation (precedes) of Positive_regulation (increased) of NK-1 in nerve associated with nervous system injury, hypersensitivity and substance p
1) Confidence 0.50 Published 2004 Journal J Pain Section Abstract Doc Link 15042514 Disease Relevance 0.82 Pain Relevance 1.07
These findings indicate that concurrent activation of spinal NMDA and substance P receptors induces an enhancement of spinal transmission of nociception, and that this enhancement is dependent on the intensity or the quality of the peripheral stimulus.
Positive_regulation (induces) of Positive_regulation (activation) of substance P in spinal associated with nociception and substance p
2) Confidence 0.49 Published 1992 Journal Pain Section Abstract Doc Link 1283010 Disease Relevance 0.17 Pain Relevance 0.29
These findings suggest that early stimulation of Tac1 is mediated by both genomic and non-genomic E2 pathways.
Positive_regulation (mediated) of Positive_regulation (stimulation) of Tac1
3) Confidence 0.48 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0.12 Pain Relevance 0.23
In conclusion, the NK1 receptor plays a functional role in mediating leukocyte accumulation independently of the historically important NK1 mediated oedema formation.
Positive_regulation (mediating) of Positive_regulation (accumulation) of NK1 in leukocyte associated with pressure and volume under development
4) Confidence 0.48 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16269189 Disease Relevance 0.39 Pain Relevance 0.36
This study demonstrates that exogenous SP, as well as endogenous tachykinins released from capsaicin-sensitive neurons, can liberate histamine, most likely from airway mast cells, by a mechanism that depends predominantly on the activation of NK1 and NK2 receptors.
Positive_regulation (depends) of Positive_regulation (activation) of NK1 in neurons associated with qutenza and substance p
5) Confidence 0.21 Published 1995 Journal J. Appl. Physiol. Section Abstract Doc Link 7542231 Disease Relevance 0 Pain Relevance 0.62
CFA also induced an upregulation of prodynorphin and neurokinin-1 (NK-1) in dorsal horn neurons, which was suppressed by intrathecal delivery of the MEK (MAP kinase kinase) inhibitor U0126.
Positive_regulation (induced) of Positive_regulation (upregulation) of NK-1 in dorsal horn associated with dorsal horn neuron and intrathecal
6) Confidence 0.13 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11784793 Disease Relevance 0.90 Pain Relevance 0.90
ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity.
Positive_regulation (induces) of Positive_regulation (upregulation) of NK-1 in spinal cord neurons associated with hypersensitivity, stimulus evoked pain, inflammatory pain, enkephalin and spinal cord
7) Confidence 0.12 Published 2002 Journal J. Neurosci. Section Title Doc Link 11784793 Disease Relevance 0.87 Pain Relevance 1.14
ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity.
Positive_regulation (contributes) of Positive_regulation (upregulation) of NK-1 in spinal cord neurons associated with hypersensitivity, stimulus evoked pain, inflammatory pain, enkephalin and spinal cord
8) Confidence 0.12 Published 2002 Journal J. Neurosci. Section Title Doc Link 11784793 Disease Relevance 0.88 Pain Relevance 1.14
Furthermore, activation of NK1 receptors or NMDA receptors is required for LTP.
Positive_regulation (required) of Positive_regulation (activation) of NK1 associated with nmda receptor and long-term potentiation
9) Confidence 0.07 Published 2007 Journal Mol Pain Section Body Doc Link PMC1904186 Disease Relevance 0.43 Pain Relevance 1.29
Activation of NK-1 in these neurons induces heat hyperalgesia via PKCepsilon-mediated potentiation of TRPV1.
Positive_regulation (induces) of Positive_regulation (Activation) of NK-1 in neurons associated with hyperalgesia
10) Confidence 0.07 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17978048 Disease Relevance 0.75 Pain Relevance 1.17
It is concluded that substance P induces contractions through the stimulation of tachykinin NK1 receptors on the smooth muscle cells.
Positive_regulation (induces) of Positive_regulation (stimulation) of NK1 in smooth muscle cells associated with substance p
11) Confidence 0.07 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7509752 Disease Relevance 0 Pain Relevance 0.53

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