INT49843

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Context Info
Confidence 0.49
First Reported 1993
Last Reported 2008
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 1.53
Pain Relevance 2.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Htr2a) cell death (Htr2a) aging (Htr2a)
plasma membrane (Htr2a) response to stress (Htr2a) cytoplasm (Htr2a)
Anatomy Link Frequency
spinal 2
frontal cortex 2
Htr2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Raphe magnus 3 100.00 Very High Very High Very High
spinal dorsal horn 2 100.00 Very High Very High Very High
tramadol 12 99.72 Very High Very High Very High
Analgesic 5 99.64 Very High Very High Very High
fluoxetine 4 99.18 Very High Very High Very High
tricyclic antidepressant 1 96.72 Very High Very High Very High
antidepressant 2 95.32 Very High Very High Very High
agonist 2 90.20 High High
Central grey 1 87.32 High High
analgesia 2 83.84 Quite High
Disease Link Frequency Relevance Heat
Arthritis 5 100.00 Very High Very High Very High
Convulsion 7 99.98 Very High Very High Very High
Urological Neuroanatomy 5 99.48 Very High Very High Very High
Inflammatory Pain 1 82.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic fluoxetine or desmethylimipramine treatment alters 5-HT2 receptor mediated c-fos gene expression.
Positive_regulation (mediated) of Gene_expression (expression) of 5-HT2 associated with fluoxetine
1) Confidence 0.49 Published 1995 Journal Eur. J. Pharmacol. Section Title Doc Link 7589222 Disease Relevance 0.08 Pain Relevance 0.45
Expression of the 5-HT2A receptor mRNA in NRM, ipsilateral vlPAG, and the ipsilateral spinal dorsal horn of arthritic rats was significantly increased after tramadol treatment.
Positive_regulation (increased) of Gene_expression (Expression) of 5-HT2A in spinal associated with tramadol, raphe magnus, spinal dorsal horn and arthritis
2) Confidence 0.49 Published 2008 Journal Brain Res. Section Abstract Doc Link 18417104 Disease Relevance 0.61 Pain Relevance 2.14
Chronic electroconvulsive seizures increase the expression of serotonin2 receptor mRNA in rat frontal cortex.
Positive_regulation (increase) of Gene_expression (expression) of serotonin2 receptor in frontal cortex associated with convulsion and urological neuroanatomy
3) Confidence 0.08 Published 1993 Journal J. Neurochem. Section Title Doc Link 8376984 Disease Relevance 0.84 Pain Relevance 0.25

General Comments

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