INT49862

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 3.49
Pain Relevance 2.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biosynthetic process (Gpt) cellular_component (Gpt) biological_process (Gpt)
cytoplasm (Gpt)
Anatomy Link Frequency
liver 4
blood 2
body 2
Gpt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 19 100.00 Very High Very High Very High
Glutamate 9 100.00 Very High Very High Very High
Inflammation 9 95.68 Very High Very High Very High
Analgesic 4 83.08 Quite High
opioid receptor 2 76.64 Quite High
antagonist 1 73.04 Quite High
Opioid 1 72.60 Quite High
Bile 3 51.68 Quite High
adenocard 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 37 99.82 Very High Very High Very High
Injury 8 99.74 Very High Very High Very High
Arthritis 2 98.72 Very High Very High Very High
Granuloma 1 96.96 Very High Very High Very High
Increased Venous Pressure Under Development 2 96.40 Very High Very High Very High
Death 3 96.00 Very High Very High Very High
INFLAMMATION 9 95.68 Very High Very High Very High
Pressure And Volume Under Development 2 92.48 High High
Heart Rate Under Development 1 89.44 High High
Pressure Volume 2 Under Development 1 88.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of rats with plant extract (500 mg/kg, orally twice daily for two days) prevented (P < 0.01) the acetaminophen (640 mg/kg) as well as CCl4 (1.5 ml/kg)-induced rise in serum transaminases (GOT and GPT). 4.
Negative_regulation (prevented) of Positive_regulation (-induced) of GPT associated with paracetamol
1) Confidence 0.41 Published 1995 Journal Gen. Pharmacol. Section Abstract Doc Link 7590079 Disease Relevance 0.26 Pain Relevance 0.44
Pretreatment of rats with plant extract (500 mg/kg, orally twice daily for 2 days) prevented (P < 0.001) the paracetamol (640 mg/kg)-induced rise in serum enzymes alkaline phosphatase (ALP) and transaminases (GOT and GPT), whereas the same dose of the extract was unable to prevent (P > 0.05) the CCI4-induced rise in serum enzyme levels. 4.
Negative_regulation (prevented) of Positive_regulation (-induced) of GPT associated with paracetamol
2) Confidence 0.41 Published 1996 Journal Gen. Pharmacol. Section Abstract Doc Link 8909978 Disease Relevance 0.17 Pain Relevance 0.44
Further, Wong et al. [4] have tested the effects of three seaweeds, and found that Sargassum henslowianum exhibited significant protection against carbon tetrachloride-induced liver injury in rats, by reducing the acute increase of glutamate oxaloacetate transaminase (GOT) and glutamate pyruvate transaminase (GPT) levels.
Negative_regulation (reducing) of Positive_regulation (increase) of GPT in liver associated with glutamate and injury
3) Confidence 0.33 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2291455 Disease Relevance 0.57 Pain Relevance 0.22
Naltrexone significantly reduced the elevation of serum glutamate-oxalacetate transaminase and glutamate-pyruvate transaminase (as index of hepatic function) induced by LPS.
Negative_regulation (reduced) of Positive_regulation (elevation) of glutamate-pyruvate transaminase associated with glutamate
4) Confidence 0.31 Published 2005 Journal J. Biomed. Sci. Section Abstract Doc Link 15917999 Disease Relevance 0.59 Pain Relevance 0.28
Pretreatment of rats with plant extract (500 mg/kg) significantly lowered (P < 0.05) the respective serum ALP; GOT and GPT levels to 192 +/- 31, 63 +/- 9 and 35 +/- 8. 5.
Negative_regulation (lowered) of Positive_regulation (levels) of GPT
5) Confidence 0.31 Published 1995 Journal Gen. Pharmacol. Section Abstract Doc Link 7789738 Disease Relevance 0.24 Pain Relevance 0.40
For the acute administration of chemicals in high doses, in the rat liver microsomes a decrease of cytochrome P450, aniline hydroxylase and glutathione (GSH) was noticed with an increase of lipid peroxides even at 2 hours after administration. 24 hours after the chemicals administration, in the blood of rats characteristic changes of hepatotoxicity such as increases glutamate-pyruvate transminase, triglycerides and lipid peroxides, while GSH was decreased.
Negative_regulation (decreased) of Positive_regulation (increases) of glutamate-pyruvate transminase in blood associated with glutamate and hepatotoxicity
6) Confidence 0.23 Published 2002 Journal Rocz. Akad. Med. Bialymst. Section Abstract Doc Link 12533950 Disease Relevance 0.49 Pain Relevance 0.13
The results showed that the sGOT and the sGPT activities, increased by APAP, were decreased significantly (P < 0.05) through treatment with inceasing amounts up to 1000 mg/kg body wt. of the exracts.
Negative_regulation (decreased) of Positive_regulation (increased) of sGPT in body
7) Confidence 0.14 Published 2001 Journal Phytomedicine Section Abstract Doc Link 11417915 Disease Relevance 0.26 Pain Relevance 0.19
Further, the product inhibited the increased level of serum lysosomal enzyme activity viz. serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, alkaline phosphatase and the lipid peroxidation in liver.
Negative_regulation (inhibited) of Positive_regulation (increased) of serum glutamic pyruvic transaminase in liver
8) Confidence 0.12 Published 2007 Journal Indian J. Exp. Biol. Section Abstract Doc Link 17373374 Disease Relevance 0.91 Pain Relevance 0.50

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox