INT49867

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Context Info
Confidence 0.39
First Reported 1995
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.07
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Polg) aging (Polg)
Anatomy Link Frequency
poly 3
liver 1
Polg (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 4 98.56 Very High Very High Very High
Paracetamol 18 98.44 Very High Very High Very High
Inflammation 4 97.82 Very High Very High Very High
cINOD 3 97.60 Very High Very High Very High
Glutamate 4 83.56 Quite High
imagery 2 69.88 Quite High
tolerance 1 69.24 Quite High
Analgesic 1 25.00 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 6 99.12 Very High Very High Very High
Hepatotoxicity 4 98.74 Very High Very High Very High
INFLAMMATION 7 98.38 Very High Very High Very High
Hepatitis 5 97.44 Very High Very High Very High
Death 9 97.04 Very High Very High Very High
Critical Illness 2 96.80 Very High Very High Very High
Stress 3 96.00 Very High Very High Very High
Injury 2 95.48 Very High Very High Very High
Targeted Disruption 2 95.28 Very High Very High Very High
Herpes Simplex Virus 3 93.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It remains unclear why Polg and Lig3 RNA levels were decreased while Tfam transcript levels were unchanged.
Negative_regulation (decreased) of Polg
1) Confidence 0.39 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2715231 Disease Relevance 0 Pain Relevance 0
The Thal-induced exacerbation of AAP hepatotoxicity was completely inhibited by nicotinic acid amide, a selective inhibitor of poly(ADP-ribose) polymerase (PARP) (P < 0.0001), suggesting a possible influence of Thal on the hepatic metabolism of NAD-adenoribosylation. 4.
Negative_regulation (inhibitor) of polymerase in poly associated with paracetamol and hepatotoxicity
2) Confidence 0.05 Published 1995 Journal Gen. Pharmacol. Section Abstract Doc Link 7590113 Disease Relevance 0.25 Pain Relevance 0.75
Since inhibitors of the nuclear enzyme poly-(ADP-ribose) polymerase (PARP) were found to be beneficial in many pathophysiological conditions associated with oxidative stress and PARP-1 knock-out mice proved to be resistant to bacterial lipopolysaccharide (LPS)-induced septic shock, PARP inhibitors are candidates for such a role.
Negative_regulation (inhibitors) of polymerase in poly associated with targeted disruption, stress and sepsis
3) Confidence 0.05 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 12694878 Disease Relevance 0.76 Pain Relevance 0.20
Decrease of the inflammatory response and induction of the Akt/protein kinase B pathway by poly-(ADP-ribose) polymerase 1 inhibitor in endotoxin-induced septic shock.
Negative_regulation (inhibitor) of polymerase in poly associated with inflammatory response, inflammation and sepsis
4) Confidence 0.04 Published 2003 Journal Biochem. Pharmacol. Section Title Doc Link 12694878 Disease Relevance 0.96 Pain Relevance 0.32
Recently, we demonstrated the hepatoprotective effects of nicotinic acid amide, a selective inhibitor of poly(ADP-ribose) polymerase (PARP; EC 2.4.2.30) on mice suffering from acetaminophen (AAP)-hepatitis, suggesting that the AAP-induced liver injury involves a step which depends on adenoribosylation.
Negative_regulation (inhibitor) of polymerase in liver associated with paracetamol, injury and hepatitis
5) Confidence 0.02 Published 1996 Journal Gen. Pharmacol. Section Abstract Doc Link 8742498 Disease Relevance 0.41 Pain Relevance 0.56
Had SCH 16 been an un-coating inhibitor or a polymerase inhibitor, the drug would have required a contact time of less than 4 hours to bring about its inhibitory effect.
Negative_regulation (inhibitor) of polymerase
6) Confidence 0.01 Published 2008 Journal Virol J Section Body Doc Link PMC2408923 Disease Relevance 0.27 Pain Relevance 0
GCV, a kind of antiviral drug, can be phosphorylated by HSVtK protein finally into triphosphates, which are potent inhibitors of DNA polymerase, leading to the disruption of cellular DNA synthesis and ultimately cell death.
Negative_regulation (inhibitors) of polymerase associated with death
7) Confidence 0.01 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1463003 Disease Relevance 1.42 Pain Relevance 0.03

General Comments

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