INT4988

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Context Info
Confidence 0.77
First Reported 1988
Last Reported 2011
Negated 13
Speculated 2
Reported most in Body
Documents 64
Total Number 67
Disease Relevance 43.40
Pain Relevance 4.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KRT1) cytoskeleton (KRT1)
Anatomy Link Frequency
neuron 5
granulation 2
keratinocyte 2
muscle 2
epithelial cells 2
KRT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 56 99.60 Very High Very High Very High
chemokine 4 97.12 Very High Very High Very High
Somatostatin 6 93.88 High High
Acupuncture 98 93.84 High High
Opioid 5 93.84 High High
Enkephalin 7 93.20 High High
palliative 9 91.80 High High
abdominal pain 22 91.56 High High
Angina 3 90.80 High High
cva 51 90.52 High High
Disease Link Frequency Relevance Heat
Choriocarcinoma 10 99.92 Very High Very High Very High
Cancer 1189 99.86 Very High Very High Very High
Skin Cancer 153 99.86 Very High Very High Very High
Pseudomyxoma Peritonei 88 99.68 Very High Very High Very High
INFLAMMATION 49 99.60 Very High Very High Very High
Lung Cancer 41 99.24 Very High Very High Very High
Paraganglioma 39 99.04 Very High Very High Very High
Pleural Solitary Fibrous Tumor 5 98.56 Very High Very High Very High
Carcinoma 217 98.52 Very High Very High Very High
Clear Cell Sarcoma 20 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Paraganglioma of the cauda equina with papillary pattern and cytokeratin expression: 2 potential sources of diagnostic error.
Gene_expression (expression) of cytokeratin associated with paraganglioma
1) Confidence 0.77 Published 2001 Journal Gac Med Mex Section Title Doc Link 11692814 Disease Relevance 0.71 Pain Relevance 0.07
Despite their association with terminal epidermal differentiation and keratinization, K1 and K10 may be focally expressed in suprabasal cells of internal noncornifying stratified squamous epithelia (for references, see Moll 1998).
Gene_expression (expressed) of K1 in internal
2) Confidence 0.68 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.50 Pain Relevance 0
In squamous cell carcinomas focal expression of K1 and K10, usually in relation to maturation and keratinization, can be observed regardless of whether they are derived from the skin or from internal organs (for references, see Moll 1998).
Gene_expression (expression) of K1 in skin associated with skin cancer
3) Confidence 0.68 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.51 Pain Relevance 0
Similarly to IFs, keratins are expressed in a tissue-specific manner, with different pairs being the major cellular IFs in different cell populations (Moll et al. 1982; Ku et al. 1999; Coulombe and Omary 2002).
Gene_expression (expressed) of keratin
4) Confidence 0.65 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.07 Pain Relevance 0
Examination of the biopsy by immunohistochemistry and ultrastructural study revealed it to be neuroendocrine in nature, expressing synaptophysin, chromogranin and cytokeratin and containing dense core cytoplasmic granules.
Gene_expression (expressing) of cytokeratin
5) Confidence 0.60 Published 2009 Journal Dig Endosc Section Abstract Doc Link 19691767 Disease Relevance 0.50 Pain Relevance 0.17
In both samples tumor cells coexpressed cytokeratin and vimentin.
Gene_expression (coexpressed) of cytokeratin associated with cancer
6) Confidence 0.60 Published 1996 Journal Diagn. Cytopathol. Section Abstract Doc Link 8732655 Disease Relevance 1.06 Pain Relevance 0.09
K1/K10: major keratins of keratinocyte differentiation and keratinization
Gene_expression (/) of K1 in keratinocyte
7) Confidence 0.59 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.97 Pain Relevance 0.03
Overall, K1 and K10 can be regarded as “keratinization markers” of keratinocytes.
Gene_expression (regarded) of K1 in keratinocytes
8) Confidence 0.59 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.53 Pain Relevance 0
Focally, there may be expression of K1/K10 (particularly in higher differentiated tumor cells which can end in the formation of horn pearls), and—to a lesser extent—K4 and K13.
Gene_expression (expression) of K1 in horn associated with cancer
9) Confidence 0.53 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.97 Pain Relevance 0
Immunocytochemistry revealed these anaplastic cells to be cytokeratin and placenta-like alkaline phosphatase positive but S100, CD30 and lymphoid marker negative.
Neg (negative) Gene_expression (positive) of cytokeratin in placenta
10) Confidence 0.33 Published 2000 Journal Ann. Oncol. Section Abstract Doc Link 10942066 Disease Relevance 0.72 Pain Relevance 0.08
Cytokeratin is expressed in over 80%.
Gene_expression (expressed) of Cytokeratin
11) Confidence 0.32 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC3016302 Disease Relevance 1.40 Pain Relevance 0.09
According to the ancient TCM book, Nan Jing (Classic of Difficulties), the acupoint, K1 (Yongquan), is one of the Well (Jing) points.
Gene_expression (book) of K1
12) Confidence 0.29 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952336 Disease Relevance 0.18 Pain Relevance 0.41
Based upon the ancient TCM book, Nan Jing (Classic of Difficulties), the acupoint, K1 (Yongquan), is one of the Well (Jing) points.
Gene_expression (book) of K1
13) Confidence 0.29 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952336 Disease Relevance 0.39 Pain Relevance 0.25
Immunohistochemically, the tumor cells of the epithelial component were positive for embryonal membrane antigen (EMA), carcinoembryonic antigen (CEA), human mesothelial cells (HBME)-1, and cytokeratin, and the spindle cells were positive for vimentin.
Gene_expression (positive) of cytokeratin in spindle cells associated with cancer
14) Confidence 0.27 Published 2002 Journal Med Electron Microsc Section Abstract Doc Link 12181652 Disease Relevance 0.63 Pain Relevance 0.12
Some cells expressed cytokeratin, CK5, desmin and myogenine (Figure 6C).
Gene_expression (expressed) of cytokeratin
15) Confidence 0.25 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC3016302 Disease Relevance 1.33 Pain Relevance 0.13
Immunohistochemically, these rhabdoid cells were positive for vimentin, epithelial membrane antigen, smooth-muscle actin, cytokeratin, S-100 protein, and glial fibrillary acidic protein.
Gene_expression (positive) of cytokeratin in muscle
16) Confidence 0.20 Published 2007 Journal Arq Neuropsiquiatr Section Abstract Doc Link 17876420 Disease Relevance 1.12 Pain Relevance 0.16
Stain for cytokeratin was negative while tumor cells were positive for vimentin.
Neg (negative) Gene_expression (negative) of cytokeratin associated with cancer
17) Confidence 0.20 Published 2006 Journal BMC Urol Section Body Doc Link PMC1513593 Disease Relevance 0.65 Pain Relevance 0.10
Stain for cytokeratin is negative while tumor cells are positive for vimentin in clear cell sarcoma of the kidney.
Neg (negative) Gene_expression (negative) of cytokeratin in kidney associated with cancer and clear cell sarcoma
18) Confidence 0.20 Published 2006 Journal BMC Urol Section Body Doc Link PMC1513593 Disease Relevance 1.49 Pain Relevance 0.04
Immunohistochemically, the neuroendocrine areas were reactive for C-kit, epithelial membrane antigen, cytokeratin, cytokeratin 7, chromogranin A, neuron-specific enolase, CD56 and S-100 protein.
Gene_expression (reactive) of cytokeratin in neuron
19) Confidence 0.19 Published 2008 Journal APMIS Section Abstract Doc Link 19024610 Disease Relevance 1.17 Pain Relevance 0.08
The neoplastic cells stained positively for cytokeratin and the beta subunit of human chorionic gonadotropin (beta-HCG).
Gene_expression (stained) of cytokeratin
20) Confidence 0.15 Published 1991 Journal Can. J. Ophthalmol. Section Abstract Doc Link 1751915 Disease Relevance 0.48 Pain Relevance 0.17

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