INT49884

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Context Info
Confidence 0.55
First Reported 1995
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 14.06
Pain Relevance 8.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
macrophages 4
blood 2
T lymphocyte 2
Il4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 307 100.00 Very High Very High Very High
dorsal root ganglion 46 100.00 Very High Very High Very High
chemokine 3 100.00 Very High Very High Very High
Thermal hyperalgesia 24 99.96 Very High Very High Very High
Sciatic nerve 1 99.40 Very High Very High Very High
Migraine 10 99.32 Very High Very High Very High
Analgesic 13 99.28 Very High Very High Very High
cytokine 237 98.64 Very High Very High Very High
Eae 68 98.16 Very High Very High Very High
Neuritis 9 97.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 333 100.00 Very High Very High Very High
Ganglion Cysts 48 100.00 Very High Very High Very High
Hyperalgesia 28 99.96 Very High Very High Very High
Hypersensitivity 42 99.80 Very High Very High Very High
Headache 10 99.32 Very High Very High Very High
Lower Respiratory Tract Infection 82 98.88 Very High Very High Very High
Pancreatitis 320 98.76 Very High Very High Very High
Asthma 180 98.06 Very High Very High Very High
Experimental Autoimmune Neuritis 9 97.60 Very High Very High Very High
Immunization 4 95.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exposure to these analgesics was associated with a differential suppression of interleukin-4 production by T-cells, as well as a more generalized suppression of cytokine production by macrophages.
Negative_regulation (suppression) of Gene_expression (production) of interleukin-4 in macrophages associated with analgesic and cytokine
1) Confidence 0.55 Published 1995 Journal Immunol. Lett. Section Abstract Doc Link 7590906 Disease Relevance 0 Pain Relevance 0.31
Our results revealed that delivery of aerosolized ketamine using an ultrasonic nebulizer markedly suppressed allergen-mediated airway hyperreactivity, airway inflammation and airway inflammatory cell infiltration into the BALF, and significantly decreased the levels of interleukin-4 (IL-4) in the BALF and expression of iNOS and the concentration of NO in the inflamed airways from OVA-treated rats.
Negative_regulation (decreased) of Gene_expression (levels) of interleukin-4 associated with asthma, inflammation and ketamine
2) Confidence 0.37 Published 2007 Journal J Inflamm (Lond) Section Abstract Doc Link PMC1876456 Disease Relevance 0.75 Pain Relevance 0.60
In the experiments that are the subject of the current report, we have demonstrated that transgene-mediated expression of IL-4 in DRG effectively reduces nocifensive behaviors and blocks expression of IL-1?
Negative_regulation (reduces) of Gene_expression (expression) of IL-4 associated with dorsal root ganglion
3) Confidence 0.34 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395302 Disease Relevance 1.33 Pain Relevance 1.23
Vector-mediated IL-4 expression also reduced thermal hyperalgesia.
Negative_regulation (reduced) of Gene_expression (expression) of IL-4 associated with thermal hyperalgesia
4) Confidence 0.34 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395302 Disease Relevance 0.49 Pain Relevance 0.70
Assay of IL-4/IL-13 concentration in BALF
Negative_regulation (Assay) of Gene_expression (concentration) of IL-4
5) Confidence 0.27 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1876456 Disease Relevance 0.89 Pain Relevance 0.43
Our results revealed that delivery of aerosolized ketamine using an ultrasonic nebulizer markedly suppressed allergen-mediated airway hyperreactivity, airway inflammation and airway inflammatory cell infiltration into the BALF, and significantly decreased the levels of interleukin-4 (IL-4) in the BALF and expression of iNOS and the concentration of NO in the inflamed airways from OVA-treated rats.
Negative_regulation (decreased) of Gene_expression (levels) of IL-4 associated with asthma, inflammation and ketamine
6) Confidence 0.27 Published 2007 Journal J Inflamm (Lond) Section Abstract Doc Link PMC1876456 Disease Relevance 0.75 Pain Relevance 0.60
and decrease in the levels of IL-4 and IL-10.
Negative_regulation (decrease) of Gene_expression (levels) of IL-4
7) Confidence 0.17 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC3004822 Disease Relevance 0.80 Pain Relevance 0.13
and IL-2 increased, while the CD3+CD8+ T lymphocyte counts and the levels of IL-4 and IL-10 decreased.


Negative_regulation (decreased) of Gene_expression (levels) of IL-4 in T lymphocyte
8) Confidence 0.15 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC1821034 Disease Relevance 0.75 Pain Relevance 0.08
This clinical effect was associated with dose-dependent down-regulated production of IFN-gamma and the chemokines macrophage inflammatory protein-1 alpha (MIP-1 alpha, MIP-2 and monocyte chemotactic protein-1(MCP-1) as well as up-regulated IL-4 production in sciatic nerve sections from Rolipram-treated EAN rats at maximum of clinical EAN, i.e. on day 14 p.i..
Negative_regulation (down-regulated) of Gene_expression (production) of IL-4 in macrophage associated with chemokine, inflammation, sciatic nerve and neuritis
9) Confidence 0.14 Published 2000 Journal Autoimmunity Section Abstract Doc Link 11078155 Disease Relevance 1.48 Pain Relevance 1.18
Another study on athletes reported a reduction in IL-4 production in the supplemented group after a 30-km run (54), reinforcing the potential change in the type of immune response presented by the athletes who received branched chain amino acids as precursors for glutamine synthesis, and its diversion towards a Th1 type response, which promotes cellular immunity (55).
Negative_regulation (reduction) of Gene_expression (production) of IL-4
10) Confidence 0.10 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC442120 Disease Relevance 0.39 Pain Relevance 0
synthesis, and down-regulates Th2 response, inhibiting IL-4 production, in allergic children with RRI (Ciprandi et al 2004).
Negative_regulation (inhibiting) of Gene_expression (production) of IL-4 associated with hypersensitivity and lower respiratory tract infection
11) Confidence 0.07 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936284 Disease Relevance 0.61 Pain Relevance 0.05
Furthermore, they reduce the production of IL4, which specifically regulates the development of the Th2 phenotype and leads to an increase in the synthesis of IgE, eosinophilia and atopic disease.
Negative_regulation (reduce) of Gene_expression (production) of IL4 associated with disease and eosinophilia
12) Confidence 0.07 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936284 Disease Relevance 0.51 Pain Relevance 0.08
/IL-4 ratios before and after ERCP in order to identify
Negative_regulation (/) of Gene_expression (ratios) of IL-4
13) Confidence 0.07 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2486352 Disease Relevance 0.93 Pain Relevance 0.31
According to our results, neither IL-2 levels nor IL-2/IL-4 ratios
Negative_regulation (/) of Gene_expression (ratios) of IL-4
14) Confidence 0.07 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2486352 Disease Relevance 0.89 Pain Relevance 0.36
According to our results, neither IL-2 levels nor IL-2/IL-4 ratios
Neg (nor) Negative_regulation (nor) of Gene_expression (ratios) of IL-4
15) Confidence 0.07 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2486352 Disease Relevance 0.89 Pain Relevance 0.36
levels of IL-4 at 24 hours after ERCP were lower in the patients with post-ERCP
Negative_regulation (lower) of Gene_expression (levels) of IL-4
16) Confidence 0.07 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2486352 Disease Relevance 0.87 Pain Relevance 0.16
A sharp decrease in the expression of ICAM-1 (F=5.09, p<0.001 and F=2.46, p<0.05, respectively), sICAM-1 1 (F=6.21, p<0.0001 and F=3.99, p<0.007, respectively) and serum IL-4 (F=6.23, p<0.001 and F=3.64, p<0.01, respectively) were observed in experimentally induced and spontaneous migraine attacks.
Negative_regulation (decrease) of Gene_expression (expression) of IL-4 associated with migraine
17) Confidence 0.04 Published 1997 Journal J. Mol. Med. Section Abstract Doc Link 9231885 Disease Relevance 1.15 Pain Relevance 0.88
An altered Th1/Th2 balance, characterized by reduced IL-4, IFN-gamma and TNF-alpha but normal IL-2 levels, was present in untreated heroin addicted subjects, while the Th1/Th2 balance was well conserved in the methadone and buprenorphine groups.
Negative_regulation (reduced) of Gene_expression (levels) of IL-4 associated with methadone and buprenorphine
18) Confidence 0.01 Published 2008 Journal Brain Behav. Immun. Section Abstract Doc Link 18294814 Disease Relevance 0.23 Pain Relevance 1.23
IL-2, IL-4, IFN, TNF, perforin, granzyme B (GrB), and FasL mRNA expression levels were determined in peripheral blood mononuclear cells by competitive RT-PCR.
Spec (determined) Negative_regulation (determined) of Gene_expression (expression) of IL-4 in blood
19) Confidence 0.01 Published 2002 Journal Blood Cells Mol. Dis. Section Abstract Doc Link 12490285 Disease Relevance 0.36 Pain Relevance 0.23

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