INT49896

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Context Info
Confidence 0.58
First Reported 1995
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.16
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Dpys) cytoplasm (Dpys)
Anatomy Link Frequency
Pfc 2
Muscle 1
neural 1
Dpys (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 20 100.00 Very High Very High Very High
Endocannabinoid 3 98.96 Very High Very High Very High
fluoxetine 10 97.84 Very High Very High Very High
antagonist 5 97.76 Very High Very High Very High
Kinase C 8 97.04 Very High Very High Very High
Antinociceptive 3 94.64 High High
tetrodotoxin 2 92.00 High High
Sciatic nerve 2 90.24 High High
Raphe 2 77.20 Quite High
Cannabinoid 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Paralysis 2 99.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Muscle paralysis, induced by denervation, had no effect on the DHP receptor mRNA levels while the RY receptor mRNA was decreased.
Neg (no) Regulation (effect) of DHP in Muscle associated with paralysis
1) Confidence 0.58 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7592768 Disease Relevance 0.10 Pain Relevance 0.20
These results demonstrate that neural factor(s) regulate DHP and RY receptor mRNA levels in vivo via transcriptional mechanisms while protein kinase C and cAMP can modulate DHP and RY receptor transcript levels by a transcription-independent process.
Regulation (regulate) of DHP in neural associated with kinase c
2) Confidence 0.42 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7592768 Disease Relevance 0.06 Pain Relevance 0.28
Fluoxetine (10 mg/kg, s.c.) alone produced a smaller increase in the extracellular 5-HT concentration in the Pfc than Dhp of the same rat (maximal 5-HT concentrations were 183% and 223% of the baseline values in Pfc and Dhp respectively).
Regulation (values) of Dhp in Pfc associated with hippocampus and fluoxetine
3) Confidence 0.20 Published 1999 Journal Chin J Physiol Section Abstract Doc Link 10513599 Disease Relevance 0 Pain Relevance 0.81
Fluoxetine (10 mg/kg, s.c.) alone produced a smaller increase in the extracellular 5-HT concentration in the Pfc than Dhp of the same rat (maximal 5-HT concentrations were 183% and 223% of the baseline values in Pfc and Dhp respectively).
Regulation (values) of Dhp in Pfc associated with hippocampus and fluoxetine
4) Confidence 0.18 Published 1999 Journal Chin J Physiol Section Abstract Doc Link 10513599 Disease Relevance 0 Pain Relevance 0.81
BACKGROUND: Propofol can inhibit fatty acid amidohydrolase, the enzyme responsible for the metabolism of anandamide (an endocannabinoid).
Regulation (responsible) of amidohydrolase associated with endocannabinoid
5) Confidence 0.09 Published 2007 Journal Anesth. Analg. Section Abstract Doc Link 17513659 Disease Relevance 0 Pain Relevance 0.31

General Comments

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