INT49903

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Context Info
Confidence 0.67
First Reported 1995
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.25
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Dpys) cytoplasm (Dpys)
Anatomy Link Frequency
sciatic nerve 1
Muscle 1
Dpys (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 12 99.50 Very High Very High Very High
Sciatic nerve 3 98.68 Very High Very High Very High
tetrodotoxin 3 98.22 Very High Very High Very High
Disease Link Frequency Relevance Heat
Paralysis 3 99.06 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, chronic superfusion of tetrodotoxin onto the sciatic nerve resulted in a marked increase in mRNA levels and transcriptional activity of both DHP and RY receptor genes.
Transcription (activity) of DHP in sciatic nerve associated with tetrodotoxin and sciatic nerve
1) Confidence 0.67 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7592768 Disease Relevance 0.09 Pain Relevance 0.25
Neither cAMP nor protein kinase C altered transcriptional activity of the DHP and RY receptor genes.
Transcription (activity) of DHP associated with kinase c
2) Confidence 0.50 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7592768 Disease Relevance 0.06 Pain Relevance 0.28
Muscle paralysis, induced by denervation, had no effect on the DHP receptor mRNA levels while the RY receptor mRNA was decreased.
Transcription (levels) of DHP in Muscle associated with paralysis
3) Confidence 0.50 Published 1995 Journal J. Biol. Chem. Section Abstract Doc Link 7592768 Disease Relevance 0.10 Pain Relevance 0.20

General Comments

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