INT49922

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Context Info
Confidence 0.67
First Reported 1995
Last Reported 2010
Negated 0
Speculated 5
Reported most in Abstract
Documents 21
Total Number 27
Disease Relevance 14.46
Pain Relevance 17.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf) extracellular space (Ngf) aging (Ngf)
extracellular region (Ngf) molecular_function (Ngf)
Anatomy Link Frequency
nerve 28
neurons 6
neutrophil 3
neuronal 2
peritoneum 2
Ngf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 532 100.00 Very High Very High Very High
Inflammation 43 100.00 Very High Very High Very High
Thermal hyperalgesia 1 100.00 Very High Very High Very High
qutenza 20 99.72 Very High Very High Very High
Hyperalgesia 69 99.58 Very High Very High Very High
sodium channel 7 99.58 Very High Very High Very High
nociceptor 25 99.44 Very High Very High Very High
Multiple sclerosis 5 99.04 Very High Very High Very High
allodynia 2 98.64 Very High Very High Very High
fifth nerve 2 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 71 100.00 Very High Very High Very High
INFLAMMATION 39 100.00 Very High Very High Very High
Cancer 5 99.76 Very High Very High Very High
Pheochromocytoma 3 99.54 Very High Very High Very High
Necrosis 1 99.52 Very High Very High Very High
Multiple Sclerosis 14 99.36 Very High Very High Very High
Injury 102 98.74 Very High Very High Very High
Neuropathic Pain 5 98.64 Very High Very High Very High
Polycystic Ovary Syndrome 4 98.16 Very High Very High Very High
Nervous System Injury 51 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Disc puncture resulted in nerve growth factor induction at postoperative day 3, but not apparent behavioral changes.
Positive_regulation (resulted) of Positive_regulation (induction) of nerve growth factor in nerve
1) Confidence 0.67 Published 2005 Journal Spine Section Body Doc Link 15644754 Disease Relevance 0.06 Pain Relevance 0
Involvement of nerve growth factor (NGF) in the development of this hyperalgesia is suggested by the increase in the level of mRNA encoding NGF in cells in the injured area and in dorsal root ganglia at the level of the lesion and the greatly increased NGF levels (determined by ELISA) in the ganglia ipsilateral to the CCI.
Positive_regulation (increase) of Positive_regulation (increase) of NGF in ganglia associated with hyperalgesia, nerve growth factor and eae
2) Confidence 0.50 Published 1997 Journal Neuroreport Section Abstract Doc Link 9189901 Disease Relevance 1.08 Pain Relevance 1.21
Upregulation of nerve growth factor (NGF) mRNA and protein occurred in exercised muscle over a comparable time course (12 h to 2 d after LC) for muscle mechanical hyperalgesia.
Positive_regulation (occurred) of Positive_regulation (Upregulation) of NGF in nerve associated with hyperalgesia and nerve growth factor
3) Confidence 0.50 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20220009 Disease Relevance 1.03 Pain Relevance 1.33
Upregulation of nerve growth factor (NGF) mRNA and protein occurred in exercised muscle over a comparable time course (12 h to 2 d after LC) for muscle mechanical hyperalgesia.
Positive_regulation (occurred) of Positive_regulation (Upregulation) of nerve growth factor in nerve associated with hyperalgesia and nerve growth factor
4) Confidence 0.50 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20220009 Disease Relevance 1.03 Pain Relevance 1.33
Following several weeks after injury, the sciatic functional index (SFI) values were significantly increased in groups of NAT-NGF and LBD-NGF compared with the control (n?
Positive_regulation (increased) of Positive_regulation (groups) of NAT-NGF associated with nerve growth factor and injury
5) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2703785 Disease Relevance 0.55 Pain Relevance 1.01
When the capsaicin-treated rats received 5 intraplantar injections of nerve growth factor (NGF), the prototypical neurotrophin for capsaicin-sensitive neurons, on day 1, 2, 3, 5 and 6, both the 3beta-HSD and the TRPV1 mRNA had returned to control levels at the time point 8 days after capsaicin.
Positive_regulation (received) of Positive_regulation (injections) of nerve growth factor in neurons associated with nerve growth factor and qutenza
6) Confidence 0.50 Published 2005 Journal Pharmacology Section Abstract Doc Link 15492487 Disease Relevance 0 Pain Relevance 1.00
When the capsaicin-treated rats received 5 intraplantar injections of nerve growth factor (NGF), the prototypical neurotrophin for capsaicin-sensitive neurons, on day 1, 2, 3, 5 and 6, both the 3beta-HSD and the TRPV1 mRNA had returned to control levels at the time point 8 days after capsaicin.
Positive_regulation (received) of Positive_regulation (injections) of NGF in neurons associated with nerve growth factor and qutenza
7) Confidence 0.50 Published 2005 Journal Pharmacology Section Abstract Doc Link 15492487 Disease Relevance 0 Pain Relevance 1.00
We conclude from these data that increases in IL-6 and nerve growth factor may contribute to the development of mechanical allodynia after trigeminal nerve injury, but they are not specifically correlated with the onset or duration of pain behaviors.
Spec (may) Positive_regulation (contribute) of Positive_regulation (increases) of nerve growth factor in nerve associated with pain, fifth nerve, nervous system injury, allodynia and nerve growth factor
8) Confidence 0.48 Published 2001 Journal Arch. Oral Biol. Section Abstract Doc Link 11369318 Disease Relevance 0.71 Pain Relevance 0.73
We have now examined whether the elevation in nerve growth factor (NGF) induced by the inflammation contributes to this progressive hyperalgesia.
Spec (whether) Positive_regulation (contributes) of Spec (whether) Positive_regulation (elevation) of NGF in nerve associated with hyperalgesia, inflammation and nerve growth factor
9) Confidence 0.47 Published 1997 Journal Neuroreport Section Abstract Doc Link 9141043 Disease Relevance 0.89 Pain Relevance 0.70
We have now examined whether the elevation in nerve growth factor (NGF) induced by the inflammation contributes to this progressive hyperalgesia.
Spec (whether) Positive_regulation (induced) of Spec (whether) Positive_regulation (elevation) of NGF in nerve associated with hyperalgesia, inflammation and nerve growth factor
10) Confidence 0.47 Published 1997 Journal Neuroreport Section Abstract Doc Link 9141043 Disease Relevance 0.88 Pain Relevance 0.67
The rat clonal pheochromocytoma cell line PC12 can be induced to display neurite outgrowth upon induction with nerve growth factor (NGF).
Positive_regulation (induced) of Positive_regulation (induction) of NGF in nerve associated with nerve growth factor and pheochromocytoma
11) Confidence 0.47 Published 1995 Journal J. Cancer Res. Clin. Oncol. Section Abstract Doc Link 7593129 Disease Relevance 0.17 Pain Relevance 0.34
By comparison, skin sites from neutrophil-depleted rats did not demonstrate a significant increase in neutrophil and macrophage accumulation after NGF administration.
Positive_regulation (increase) of Positive_regulation (accumulation) of NGF in neutrophil associated with nerve growth factor
12) Confidence 0.47 Published 2002 Journal J. Pathol. Section Abstract Doc Link 12015750 Disease Relevance 0.65 Pain Relevance 0.73
CFA injection resulted in mechanical and thermal hyperalgesia and an elevation in the levels of interleukin-1 beta (IL-1 beta) and nerve growth factor (NGF) in the ipsilateral hindpaw.
Positive_regulation (resulted) of Positive_regulation (elevation) of nerve growth factor in nerve associated with nerve growth factor and thermal hyperalgesia
13) Confidence 0.46 Published 1996 Journal Neuropharmacology Section Abstract Doc Link 8887968 Disease Relevance 0.75 Pain Relevance 0.80
Inflammation results in an early and maintained elevation in nerve growth factor (NGF) levels in inflamed tissues.
Positive_regulation (results) of Positive_regulation (elevation) of nerve growth factor in nerve associated with nerve growth factor and inflammation
14) Confidence 0.46 Published 1996 Journal Philos. Trans. R. Soc. Lond., B, Biol. Sci. Section Abstract Doc Link 8730783 Disease Relevance 0.57 Pain Relevance 0.65
HFES of sympathetic neurons induced a frequency dependent NGF and NT-3 gene and protein up-regulation (relative NGF protein expression: 0Hz=1+/-0.0 vs. 5Hz=1.13+/-0.19 vs. 50Hz=1.77+/-0.08, all n=5, 0Hz/5Hz vs. 50Hz p<0.05), with a subsequent increase of growth associated protein 43 (GAP-43) expression and morphological SNS.
Positive_regulation (induced) of Positive_regulation (up-regulation) of NGF in neurons associated with nerve growth factor
15) Confidence 0.46 Published 2010 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 20138055 Disease Relevance 0.31 Pain Relevance 0.44
Our previous studies have shown that sustained activation of NGF/PI3K/Akt/NF-kappaB signaling is essential for NGF-induced dor gene expression during neuronal differentiation and that the epigenetic modifications at histone 3 lysine 9 temporally correlate with the dor gene transcription.
Positive_regulation (essential) of Positive_regulation (activation) of NGF in neuronal associated with nerve growth factor
16) Confidence 0.45 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20399742 Disease Relevance 0.09 Pain Relevance 0.52
Mangiferin stimulated cell proliferation and induced a significant increase in the supernatant levels of nerve growth factor (NGF) and tumor necrosis factor (TNF)-alpha in vitro in human U138-MG glioblastoma cells.
Positive_regulation (induced) of Positive_regulation (increase) of NGF in nerve associated with necrosis, nerve growth factor, glioblastoma and cancer
17) Confidence 0.45 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20303935 Disease Relevance 0.72 Pain Relevance 0.30
Following several weeks after injury, the sciatic functional index (SFI) values were significantly increased in groups of NAT-NGF and LBD-NGF compared with the control (n?
Positive_regulation (increased) of Positive_regulation (groups) of LBD-NGF associated with nerve growth factor and injury
18) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2703785 Disease Relevance 0.55 Pain Relevance 1.02
We presume that peritoneum surgery resulted in an increase of NGF concentrations at the ovarian level, which in turn induced hyper-androgenism, as observed in women with PCO [20].
Positive_regulation (increase) of Positive_regulation (induced) of NGF in peritoneum associated with nerve growth factor and polycystic ovary syndrome
19) Confidence 0.40 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1564398 Disease Relevance 0.36 Pain Relevance 0.23
Previous reports have suggested that SP and BDNF may co-localize in the same large dense-core vesicles (LDCVs) of the small diameter primary nociceptors, and that their release is dependent on the activation of tyrosine kinase A (trkA) receptors due to enlarged levels of nerve growth factor (NGF) in the periphery [14].
Positive_regulation (dependent) of Positive_regulation (activation) of nerve growth factor in nerve associated with nerve growth factor, nociceptor and substance p
20) Confidence 0.36 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 0.47 Pain Relevance 0.85

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