INT4993

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Context Info
Confidence 0.66
First Reported 1985
Last Reported 2009
Negated 3
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 11.04
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuron 11
smooth muscle 1
filament 1
Lrrc23 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 7 100.00 Very High Very High Very High
Somatostatin 2 98.80 Very High Very High Very High
vincristine 1 95.52 Very High Very High Very High
cva 6 93.36 High High
Opioid 1 91.84 High High
Pain 4 88.84 High High
Serotonin 1 85.68 High High
Inflammation 4 85.00 Quite High
Angina 2 79.52 Quite High
abdominal pain 3 79.48 Quite High
Disease Link Frequency Relevance Heat
Cancer 48 99.76 Very High Very High Very High
Ganglion Cysts 3 99.76 Very High Very High Very High
Lung Cancer 5 99.00 Very High Very High Very High
Granular Cell Tumor 1 97.72 Very High Very High Very High
Myxoma 5 97.52 Very High Very High Very High
Neurofibroma 1 93.64 High High
Granuloma 1 93.44 High High
Cv General 3 Under Development 4 93.36 High High
Aggression 1 92.08 High High
Paraganglioma 12 92.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical staining of the neoplastic spindle cells was positive for S-100 antigen, neuron-specific enolase, and glial fibrillary acidic protein.
Gene_expression (positive) of neuron-specific enolase in neuron
1) Confidence 0.66 Published 2009 Journal J. Vet. Diagn. Invest. Section Abstract Doc Link 19139514 Disease Relevance 0.67 Pain Relevance 0.09
Immunohistochemically, the tumor cells were positive for anti-epithelial membrane antigen, vimentin, desmin, neuron-specific enolase and WT1 protein antibodies.
Gene_expression (positive) of neuron-specific enolase in neuron associated with cancer
2) Confidence 0.32 Published 2000 Journal Pathol. Int. Section Abstract Doc Link 10849332 Disease Relevance 0.98 Pain Relevance 0.08
Immunohistochemically, the tumor cells were positive for anti-epithelial membrane antigen, vimentin, desmin, neuron-specific enolase and WT1 protein antibodies.
Gene_expression (antibodies) of neuron-specific enolase in neuron associated with cancer
3) Confidence 0.32 Published 2000 Journal Pathol. Int. Section Abstract Doc Link 10849332 Disease Relevance 0.96 Pain Relevance 0.07
The ganglion cells were positive for leu-enkephalin, neurofilament, neuron-specific enolase, pancreatic polypeptide, and somatostatin in three cases, and glucagon in one.
Gene_expression (positive) of neuron-specific enolase in neuron associated with ganglion cysts, somatostatin and enkephalin
4) Confidence 0.14 Published 1985 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 2578747 Disease Relevance 1.06 Pain Relevance 0.29
Immunohistochemical studies demonstrated positive immunoreactivity for neuron-specific enolase, synaptophysin, chromogranin, vimentin, S-100 protein and p30-32 MIC-2 gene product.
Gene_expression (product) of neuron-specific enolase in neuron
5) Confidence 0.13 Published 2005 Journal Acta Otolaryngol. Section Abstract Doc Link 15823816 Disease Relevance 0.74 Pain Relevance 0.13
Vimentin, S-100 protein and neuron specific enolase was positive in immunological staining and the pathological diagnosis was myxoma.
Gene_expression (positive) of neuron specific enolase in neuron associated with myxoma
6) Confidence 0.12 Published 2001 Journal No Shinkei Geka Section Abstract Doc Link 11452499 Disease Relevance 1.80 Pain Relevance 0.26
Glial fibrillary acid protein was focally positive, and neuron-specific enolase was negative.
Neg (negative) Gene_expression (negative) of neuron-specific enolase in neuron
7) Confidence 0.12 Published 1989 Journal Mod. Pathol. Section Abstract Doc Link 2493641 Disease Relevance 0.76 Pain Relevance 0.05
Fifteen cases studied immunohistochemically were reactive for vimentin and alpha-1-antitrypsin, 13 expressed neuron-specific enolase, 2 expressed cytokeratin, and 1 expressed S-100 protein.
Gene_expression (expressed) of neuron-specific enolase in neuron
8) Confidence 0.07 Published 1992 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 1283055 Disease Relevance 0.41 Pain Relevance 0.14
Immunohistochemically, the ovoid cells were positive for neuron-specific enolase, S-100, CAM5.2, Leu7, and chromogranin A, and negative for carcinoembryonic antigen and epithelial membrane antigen.
Neg (negative) Gene_expression (positive) of neuron-specific enolase in neuron
9) Confidence 0.05 Published 1999 Journal Surg. Today Section Abstract Doc Link 10552341 Disease Relevance 0.73 Pain Relevance 0.08
The tumour was characterized immunohistochemically by the presence of neurofilament protein, glial fibrillary acidic protein, S-100 protein, neuron-specific enolase, chromogranin A, ACTH, leu-enkephalin and vasoactive intestinal polypeptide, and ultrastructurally by demonstration of neurosecretory granules and paranuclear intermediate filament whorls.
Gene_expression (presence) of neuron-specific enolase in filament associated with cancer and enkephalin
10) Confidence 0.04 Published 1990 Journal Virchows Arch A Pathol Anat Histopathol Section Abstract Doc Link 2117315 Disease Relevance 0.43 Pain Relevance 0.10
The lack of detectable expression of neurofilament, met-enkephalin and leu-enkephalin, and neuron-specific enolase is interpreted as evidence against the paraganglial theory of histogenesis.
Gene_expression (expression) of neuron-specific enolase in neuron associated with enkephalin
11) Confidence 0.04 Published 1987 Journal Cancer Section Abstract Doc Link 2438029 Disease Relevance 0.77 Pain Relevance 0.41
Immunohistochemical examination showed proliferating spindle cells, which were positive for vimentin and smooth muscle actin, but negative for desmin, CD34, cytokeratin, epithelial membrane antigen, S100 protein, and neuron specific enolase.
Neg (negative) Gene_expression (negative) of neuron specific enolase in neuron
12) Confidence 0.04 Published 2007 Journal Surg. Today Section Abstract Doc Link 17243033 Disease Relevance 0.79 Pain Relevance 0.19
Immunohistochemically, the tumor cells were immunoreactive for smooth muscle actin and vimentin and non-immunoreactive for CD34, CD117, desmin, pan-cytokeratin, synaptophisin, neuron-specific enolase and S-100 protein.
Gene_expression (immunoreactive) of neuron-specific enolase in smooth muscle associated with cancer
13) Confidence 0.04 Published 2006 Journal Dis. Esophagus Section Abstract Doc Link 16723001 Disease Relevance 0.93 Pain Relevance 0.10

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