INT49930

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Context Info
Confidence 0.37
First Reported 1995
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 13.27
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ighg1)
Anatomy Link Frequency
Mouse 1
immune system 1
skin 1
2B5 1
Ighg1 (Mus musculus)
Pain Link Frequency Relevance Heat
Infliximab 115 99.06 Very High Very High Very High
rheumatoid arthritis 69 98.64 Very High Very High Very High
dexamethasone 8 98.00 Very High Very High Very High
Multiple sclerosis 35 95.84 Very High Very High Very High
cytokine 81 95.24 Very High Very High Very High
Inflammation 149 92.84 High High
Spinal cord 56 91.84 High High
agonist 31 90.84 High High
imagery 6 90.08 High High
Adalimumab 1 89.28 High High
Disease Link Frequency Relevance Heat
Infection 119 100.00 Very High Very High Very High
Anaphylaxis 6 99.76 Very High Very High Very High
Helminth Infection 39 99.64 Very High Very High Very High
Disease 452 99.08 Very High Very High Very High
Peanut Hypersensitivity 3 99.04 Very High Very High Very High
Rheumatoid Arthritis 71 98.64 Very High Very High Very High
Neuromyelitis Optica 430 97.92 Very High Very High Very High
Cancer 17 96.92 Very High Very High Very High
Necrosis 10 96.68 Very High Very High Very High
Multiple Sclerosis 69 95.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, our data showed that neonatal capsaicin treatment did not interfere with either IgG1 or IgE production.
IgG1 Neg (not) Binding (interfere) of
1) Confidence 0.37 Published 2001 Journal Neuroimmunomodulation Section Body Doc Link 11549890 Disease Relevance 0 Pain Relevance 0
We describe the generation of an IgG1 mAb, 2B5, that neutralizes the biologic activity of PGE2 in vitro and in vivo.
IgG1 Binding (generation) of in 2B5
2) Confidence 0.36 Published 1995 Journal J. Immunol. Section Abstract Doc Link 7594605 Disease Relevance 0 Pain Relevance 0
These IgG1 and IgG4 isotypes were also in vivo bound, as demonstrated with immunoperoxidase staining of perilesional skin.
IgG1 Binding (bound) of in skin
3) Confidence 0.36 Published 2010 Journal J Dtsch Dermatol Ges Section Abstract Doc Link 19725838 Disease Relevance 0.41 Pain Relevance 0.08
In our studies, it is possible that maternal antigen-specific IgG1 absorbed into the systemic circulation of offspring, neutralized the antigen - clearing it from the circulation prior to its recognition by cells of the adaptive immune system.
IgG1 Binding (recognition) of in immune system
4) Confidence 0.34 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 0.49 Pain Relevance 0
BD Falcon Microtest™ plates (BD Falcon, Franklin Lakes, NJ) were coated with rat anti-mouse IgG1 (A85-3), IgE (R35-72) (BD PharMingen) or goat anti-mouse IgA (Southern Biotechnology Associates), at 2 ?
IgG1 Binding (coated) of
5) Confidence 0.34 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 0 Pain Relevance 0
Recently, a murine model of peanut allergy demonstrated that maternal derived anti-peanut IgG1 is associated with anaphylactic reactions in offspring [47].
IgG1 Binding (associated) of associated with peanut hypersensitivity and anaphylaxis
6) Confidence 0.33 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2914046 Disease Relevance 1.14 Pain Relevance 0
Bound IgG1 or IgG2a/c was detected by incubation with horseradish peroxidase-conjugated sheep anti-mouse IgG1 (BD Biosciences), or an antibody that recognises both IgG2a and IgG2c (BD Biosciences), followed by TMB (3,3', 5,5'-tetramethylbenzidine) substrate.
IgG1 Binding (Bound) of
7) Confidence 0.27 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212575 Disease Relevance 0.49 Pain Relevance 0.19
kDa) was recognized later in the course of the infection by IgG1 and Ig2a isotypes.
IgG1 Binding (recognized) of associated with infection
8) Confidence 0.25 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2852613 Disease Relevance 1.05 Pain Relevance 0
Sm29 protein has been characterized by our group [8], proving to be a membrane-bound antigen on adult worms that is strongly recognized by IgG1 and IgG3 antibodies of naturally resistant individuals and patients resistant to re-infection living in endemic areas for schistosomiasis in Brazil.
IgG1 Binding (recognized) of associated with helminth infection, schistosomiasis and infection
9) Confidence 0.22 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2553283 Disease Relevance 1.21 Pain Relevance 0.07
Rat anti-mouse IgG from Zymed (San Francisco, CA, USA) was used to detect total Ig; the isotype-specific antibodies used to detect IgG1, IgG2a, and IgM were also purchased from Zymed.
IgG1 Binding (detect) of
10) Confidence 0.21 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0 Pain Relevance 0
TT-specific IgG1 titers were clearly suppressed following treatment with dexamethasone and were minimally affected following treatment with either EE or ER?
IgG1 Binding (titers) of associated with dexamethasone
11) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.67 Pain Relevance 0.31
Human monoclonal AQP4-specific IgG1 antibodies should be used to generate anti-idiotype reagents that could be used to identify AQP4 IgG1 binding in situ of autopsy tissue.
IgG1 Binding (binding) of
12) Confidence 0.20 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 0.63 Pain Relevance 0.09
Mouse monoclonal antiss-DNA antibody of the IgG isotype (IgG1 and IgG3 specifically) has a high affinity to antigen and has been shown to be hydrolytic [30].
IgG1 Binding (affinity) of in Mouse
13) Confidence 0.19 Published 2010 Journal Autoimmune Diseases Section Body Doc Link PMC2989704 Disease Relevance 0.08 Pain Relevance 0
Infliximab is a genetically engineered immunoglobulin 1 (IgG1) murine–human chimeric monoclonal antibody (Sandborn and Hanauer 1999), which binds with high affinity to both the soluble and the transmembrane forms of human tumor necrosis factor-?
IgG1 Binding (binds) of associated with necrosis, infliximab and cancer
14) Confidence 0.17 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936311 Disease Relevance 0.96 Pain Relevance 0.35
Unlabeled beta-endorphin, pentarphine, [Pro3]pentarphine, cyclopentarphine, cyclodipentarphine [cyclo(VKGFYVKGFY)], and Fc-fragment of IgG1 inhibited the binding of [3H]immunorphine to membranes from these organs.
IgG1 Binding (binding) of
15) Confidence 0.16 Published 2004 Journal Biochemistry Mosc. Section Abstract Doc Link 15170374 Disease Relevance 0 Pain Relevance 0.31
An autoantibody (IgG1) that binds AQP4 has been found in a high percentage (~75%) of NMO patients (NMO-IgG) [7].
IgG1 Binding (binds) of associated with neuromyelitis optica
16) Confidence 0.15 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 2.28 Pain Relevance 0.30
For IgG1, one log unit increase in antibodies was associated with a reduction in P. falciparum density by 1,401 parasites/?
IgG1 Binding (associated) of
17) Confidence 0.12 Published 2005 Journal Malar J Section Body Doc Link PMC1262760 Disease Relevance 0.32 Pain Relevance 0
The antigen recognition by anti-parasite IgM, IgA, IgG1, and IgG3 of symptomatic and asymptomatic individuals, determined by immunoblotting, was heterogeneous and revealed only minor differences in the response of the two groups.
IgG1 Spec (determined) Binding (recognition) of
18) Confidence 0.10 Published 1998 Journal Am. J. Trop. Med. Hyg. Section Abstract Doc Link 9502609 Disease Relevance 0.58 Pain Relevance 0.06
Infliximab was the first TNF alpha blocker for RA treatment to be clinically tested and is a genetically constructed IgG1 murine-human chimeric monoclonal antibody that binds both to the soluble subunit as well as the membrane-bound precursor of TNF-alpha [4].
IgG1 Binding (binds) of associated with infliximab and rheumatoid arthritis
19) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2762038 Disease Relevance 1.37 Pain Relevance 0.69
Most importantly all individuals receiving the vaccine developed specific immune responses and the antibodies produced were almost exclusively in the two classes IgG1 and IgG3 which can bind Fc?
IgG1 Binding (bind) of
20) Confidence 0.09 Published 2009 Journal Malar J Section Body Doc Link PMC2720982 Disease Relevance 0.23 Pain Relevance 0

General Comments

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