INT49932

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Context Info
Confidence 0.71
First Reported 1995
Last Reported 2010
Negated 5
Speculated 0
Reported most in Abstract
Documents 33
Total Number 35
Disease Relevance 8.77
Pain Relevance 7.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger3)
Anatomy Link Frequency
limb 2
cortex 2
uterus 2
brain 1
platelets 1
Ptger3 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 27 99.70 Very High Very High Very High
Hippocampus 64 99.68 Very High Very High Very High
cerebral cortex 9 99.08 Very High Very High Very High
adenocard 6 98.60 Very High Very High Very High
noradrenaline 4 98.36 Very High Very High Very High
Inflammation 45 98.24 Very High Very High Very High
Thalamus 16 97.88 Very High Very High Very High
midbrain 8 97.48 Very High Very High Very High
allodynia 12 97.06 Very High Very High Very High
Dismenorea 7 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 27 99.70 Very High Very High Very High
Cv General 2 Under Development 2 99.36 Very High Very High Very High
Hypercalcemia 8 99.24 Very High Very High Very High
INFLAMMATION 57 98.24 Very High Very High Very High
Neuropathic Pain 12 97.06 Very High Very High Very High
Dysmenorrhea 5 96.40 Very High Very High Very High
Cancer 15 95.72 Very High Very High Very High
Pressure And Volume Under Development 14 95.48 Very High Very High Very High
Pain 40 95.04 Very High Very High Very High
Natriuresis 2 94.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar expression patterns of EP3 and EP4 in the Day 4 pseudopregnant mouse uterus or in the ovariectomized uterus under combined treatment with estrogen and progesterone suggest that these genes are regulated by ovarian steroids rather than by the embryo during the preimplantation period (Days 1-4).
Gene_expression (expression) of EP3 in uterus
1) Confidence 0.71 Published 1997 Journal Biol. Reprod. Section Abstract Doc Link 9116135 Disease Relevance 0.24 Pain Relevance 0.08
In contrast, expression of EP3 in a subpopulation of cells in the stromal bed at the mesometrial side, and of EP4 in the epithelium and stroma on these days, suggests that PGE2 effects on uterine preparation for implantation (such as epithelial cell differentiation, stromal cell proliferation, uterine edema, luminal closure, and increased localized endometrial vascular permeability at the sites of blastocyst attachment) are mediated by these receptor subtypes.
Gene_expression (expression) of EP3 in uterine associated with pressure and volume under development
2) Confidence 0.71 Published 1997 Journal Biol. Reprod. Section Abstract Doc Link 9116135 Disease Relevance 0.27 Pain Relevance 0.10
Only mice lacking the EP3 receptor fail to show a febrile response to PGE2 and to either IL-1beta or LPS.
Neg (lacking) Gene_expression (lacking) of EP3 receptor in PGE2 associated with cv general 2 under development
3) Confidence 0.66 Published 1998 Journal Nature Section Abstract Doc Link 9751056 Disease Relevance 0.82 Pain Relevance 0.20
The gp120-induced allodynia was also attenuated by the non-steroidal anti-inflammatory drug indomethacin, which inhibits prostaglandin synthesis, and did not develop in mice lacking the EP3 prostaglandin E receptor subtype (EP3(-/-)).
Neg (lacking) Gene_expression (lacking) of EP3 associated with inflammation and allodynia
4) Confidence 0.65 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12814662 Disease Relevance 0.88 Pain Relevance 1.00
EP1 and EP3 mRNA expression predominates in the collecting duct and thick limb, respectively, where their stimulation reduces NaCl and water absorption, promoting natriuresis and diuresis.
Gene_expression (expression) of EP3 in limb associated with diuresis and natriuresis
5) Confidence 0.65 Published 2001 Journal Annu. Rev. Physiol. Section Abstract Doc Link 11181968 Disease Relevance 0.31 Pain Relevance 0.04
EP1 and EP3 messenger RNA expression predominate in the collecting duct and thick limb, respectively, where their stimulation reduces sodium chloride and water absorption, promoting natriuresis and diuresis.
Gene_expression (expression) of EP3 in limb associated with diuresis and natriuresis
6) Confidence 0.65 Published 2000 Journal Curr. Opin. Nephrol. Hypertens. Section Abstract Doc Link 10654821 Disease Relevance 0.40 Pain Relevance 0.10
Male C57/BL6 mice, both wild type and animals lacking EP1, EP3, or IP receptors, were used after 18 h of fasting.
Neg (lacking) Gene_expression (lacking) of EP3
7) Confidence 0.64 Published 2007 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 17928639 Disease Relevance 0 Pain Relevance 0.09
PGE2 receptors are classified into four subtypes, EP1, EP2, EP3, and EP4.
Gene_expression (classified) of EP3
8) Confidence 0.62 Published 1997 Journal Biol. Reprod. Section Abstract Doc Link 9116135 Disease Relevance 0.05 Pain Relevance 0
Similar expression patterns of EP3 and EP4 in the Day 4 pseudopregnant mouse uterus or in the ovariectomized uterus under combined treatment with estrogen and progesterone suggest that these genes are regulated by ovarian steroids rather than by the embryo during the preimplantation period (Days 1-4).
Gene_expression (patterns) of EP3 in uterus
9) Confidence 0.55 Published 1997 Journal Biol. Reprod. Section Abstract Doc Link 9116135 Disease Relevance 0.23 Pain Relevance 0.08
In conclusion, mutual interactions occur between the presynaptic H3 and EP3 receptors involved in the inhibition of noradrenaline release in the mouse brain cortex.
Gene_expression (presynaptic) of EP3 in cortex associated with noradrenaline
10) Confidence 0.54 Published 1997 Journal Neuroscience Section Abstract Doc Link 9178880 Disease Relevance 0 Pain Relevance 0.13
Expression of EP3 and FP primarily in the circular muscle of the myometrium on Days 3-5 of pregnancy suggests that the circular muscle, not the longitudinal muscle, is the primary target for PG-mediated uterine contractions required for embryo transport, spacing, and/or accommodation in the uterus.
Gene_expression (Expression) of EP3 in muscle associated with dismenorea
11) Confidence 0.48 Published 1997 Journal Biol. Reprod. Section Abstract Doc Link 9116135 Disease Relevance 0.24 Pain Relevance 0.09
The gp120-induced allodynia was also attenuated by the non-steroidal anti-inflammatory drug indomethacin, which inhibits prostaglandin synthesis, and did not develop in mice lacking the EP3 prostaglandin E receptor subtype (EP3(-/-)).
Neg (lacking) Gene_expression (lacking) of EP3 prostaglandin E receptor subtype associated with inflammation and allodynia
12) Confidence 0.48 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12814662 Disease Relevance 0.88 Pain Relevance 0.97
The underlying mechanisms of these actions of PGE2 in the stomach, duodenum, or small intestine are related to inhibition of stomach contraction (EP1), stimulation of duodenal HCO3- secretion (EP3/EP4), or suppression of bacterial invasion due to inhibition of intestinal contraction (EP4) and stimulation of mucus secretion (EP3/EP4) respectively, although the mechanisms related to the esophageal protection remain unknown.
Gene_expression (/) of EP3 in duodenum
13) Confidence 0.47 Published 2010 Journal Adv Clin Chem Section Abstract Doc Link 20857620 Disease Relevance 0.37 Pain Relevance 0.34
An in situ hybridization study showed that EP3 mRNA is expressed at a particularly high level in the regions surrounding the OVLT (Sugimoto et al. 1994).
Gene_expression (expressed) of EP3 mRNA in OVLT
14) Confidence 0.41 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0.59 Pain Relevance 0.30
A study involving Northern blot analysis and in situ hybridizatuion showed that EP3 is expressed abundantly and widely in the brain (Sugimoto et al. 1992).
Gene_expression (expressed) of EP3 in brain
15) Confidence 0.41 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.26
Moreover, both studies showed that EP2 and EP3, but not EP1 or EP4, are abundantly expressed in the hippocampus or visual cortex.
Neg (not) Gene_expression (expressed) of EP3 in cortex associated with hippocampus
16) Confidence 0.41 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.17
EP3 mRNA is expressed in the neurons of the cerebral cortex, hippocampus, thalamus, midbrain, and lower brain stem.
Gene_expression (expressed) of EP3 mRNA in cerebral cortex associated with midbrain, thalamus, hippocampus and cerebral cortex
17) Confidence 0.41 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.28
The addition of 2B5 to [3H]PGE2 blocked the binding of radioligand to cell membranes transfected with the murine EP3 prostaglandin receptor.
Gene_expression (transfected) of EP3 prostaglandin receptor in 2B5
18) Confidence 0.38 Published 1995 Journal J. Immunol. Section Abstract Doc Link 7594605 Disease Relevance 0.14 Pain Relevance 0.03
Specific immunofluorescent detection of EP3 receptor protein in oocytes was also not observed; diffuse fluorescence was observed throughout the oocyte and was only slightly diminished in the center of the oocyte by preabsorption of the primary antibody (not shown).


Gene_expression (detection) of EP3 receptor protein in oocyte
19) Confidence 0.36 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0.17
While the present study shows that EP2 and EP4 receptor proteins are expressed by mouse cumulus, further studies will be needed to confirm expression of EP3 receptor proteins.
Gene_expression (expression) of EP3
20) Confidence 0.36 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0

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