INT49957

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Context Info
Confidence 0.49
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.92
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SGCG) cytoskeleton (SGCG) cytoskeleton organization (SGCG)
cytoplasm (SGCG)
SGCG (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 4 98.80 Very High Very High Very High
Morphine 2 98.50 Very High Very High Very High
opioid receptor 7 95.80 Very High Very High Very High
mu opioid receptor 5 89.76 High High
Enkephalin 2 68.56 Quite High
agonist 1 67.04 Quite High
Disease Link Frequency Relevance Heat
Metastasis 1 100.00 Very High Very High Very High
Colon Cancer 3 96.72 Very High Very High Very High
Bordatella Infection 3 92.24 High High
Cancer 4 81.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Enhancement of type II adenylyl cyclase responses by the co-expression of alpha subunits reflects a functional coupling between alpha subunits and the mu-opioid receptor, because such potentiations were not observed with the constitutively activated alpha subunit mutants.
Positive_regulation (Enhancement) of Localization (responses) of type associated with opioid receptor
1) Confidence 0.49 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7595566 Disease Relevance 0.25 Pain Relevance 0.66
Challenge with morphine for 24 h (1 nM to 1 microM) barely affected cell proliferation, while the secretion of urokinase type plasminogen activator (a protease involved in invasion/metastasis) was markedly augmented by a concentration of 0.1 microM.
Positive_regulation (augmented) of Localization (secretion) of type associated with metastasis and morphine
2) Confidence 0.49 Published 2008 Journal Dig. Dis. Sci. Section Abstract Doc Link 17680363 Disease Relevance 0.66 Pain Relevance 0.37

General Comments

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