INT49959

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Context Info
Confidence 0.67
First Reported 1995
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.12
Pain Relevance 2.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SGCG) cytoskeleton (SGCG) cytoskeleton organization (SGCG)
cytoplasm (SGCG)
Anatomy Link Frequency
tibia 2
SGCG (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 5 99.90 Very High Very High Very High
Opioid 5 99.82 Very High Very High Very High
Morphine 5 99.36 Very High Very High Very High
Arthritis 9 99.16 Very High Very High Very High
opioid receptor 12 98.64 Very High Very High Very High
Enkephalin 2 96.56 Very High Very High Very High
agonist 3 95.04 Very High Very High Very High
rheumatoid arthritis 3 88.36 High High
Dopamine 1 85.00 Quite High
Pain 2 80.28 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 3 99.80 Very High Very High Very High
Arthritis 9 99.16 Very High Very High Very High
Nociception 1 95.28 Very High Very High Very High
Osteoporosis 2 90.64 High High
Rheumatoid Arthritis 3 88.36 High High
Acidosis 2 86.32 High High
Immunization 2 82.84 Quite High
Arthralgia 1 80.52 Quite High
Pressure And Volume Under Development 1 79.92 Quite High
Hyperalgesia 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The opioid-induced stimulation of type II adenylyl cyclase was mediated via pertussis toxin-sensitive Gi proteins, because it was abolished completely by the toxin.
Positive_regulation (mediated) of Positive_regulation (stimulation) of type associated with bordatella infection and opioid
1) Confidence 0.67 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7595566 Disease Relevance 0.24 Pain Relevance 0.69
The ensuing research established that the neuropharmacological properties of capsaicin are due to its activation of the transient receptor potential ion channel of the vanilloid type 1 (TRPV1).
Positive_regulation (due) of Positive_regulation (activation) of type associated with qutenza
2) Confidence 0.67 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464036 Disease Relevance 0.47 Pain Relevance 0.70
We next investigated whether beta gamma subunits play a role in the sensitization of type VI adenylyl cyclase activity; using expression of alpha tau to inhibit beta gamma-mediated effects, we found that the quinpirole-induced sensitization of type VI adenylyl cyclase was abolished.
Positive_regulation (quinpirole-induced) of Positive_regulation (sensitization) of type
3) Confidence 0.49 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8622641 Disease Relevance 0 Pain Relevance 0.14
Mineral density and histomorphometric assessment of bone changes in the proximal tibia early after induction of type II collagen-induced arthritis in growing and mature rats.
Positive_regulation (induction) of Positive_regulation (induction) of type in tibia associated with arthritis
4) Confidence 0.49 Published 2001 Journal J. Bone Miner. Metab. Section Title Doc Link 11281163 Disease Relevance 1.41 Pain Relevance 0.49
These molecular changes include the up-regulation and augmented phosphorylation of adenylyl cyclase type II isoforms, which underlies the ability of morphine to shift opioid receptor G protein signalling from predominantly Gialpha inhibitory to Gbetagamma stimulatory.
Positive_regulation (underlies) of Positive_regulation (up-regulation) of type associated with opioid receptor and morphine
5) Confidence 0.49 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469050 Disease Relevance 0 Pain Relevance 0.72

General Comments

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