INT49971

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Context Info
Confidence 0.35
First Reported 1995
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 2.40
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Ednra) plasma membrane (Ednra) signal transducer activity (Ednra)
Anatomy Link Frequency
ventricle 1
levers 1
pulmonary artery 1
hippocampus 1
Ednra (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 89 100.00 Very High Very High Very High
narcan 11 100.00 Very High Very High Very High
anesthesia 6 100.00 Very High Very High Very High
GABAergic 4 100.00 Very High Very High Very High
antagonist 58 99.96 Very High Very High Very High
Hippocampus 11 99.24 Very High Very High Very High
Ventral tegmentum 12 98.90 Very High Very High Very High
Nucleus accumbens 139 98.80 Very High Very High Very High
opioid receptor 7 98.56 Very High Very High Very High
alcohol 6 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Myocardial Infarction 6 99.80 Very High Very High Very High
Infarction 9 99.08 Very High Very High Very High
Hypertension 11 97.48 Very High Very High Very High
Middle Cerebral Artery Infarction 15 97.28 Very High Very High Very High
Cardiovascular Disease 4 90.16 High High
Coronary Artery Disease 1 89.92 High High
Cv General 4 Under Development 14 84.76 Quite High
Cv Unclassified Under Development 3 78.72 Quite High
Increased Venous Pressure Under Development 3 78.28 Quite High
Arrhythmias 2 Under Development 1 76.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to a direct vasoconstrictor effect, endothelins modulate vascular responses induced by different mediators.We compared the effect of subthreshold concentrations of endothelin-1 (ET) on vasoreactivity of isolated pulmonary artery (PA) and on integrated blood pressure (BP) responses in both Wistar rats and spontaneously hypertensive rats (SHR).
Regulation (effect) of ET in pulmonary artery associated with hypertension
1) Confidence 0.35 Published 2008 Journal Pharmacol Rep Section Abstract Doc Link 19211987 Disease Relevance 0.17 Pain Relevance 0.11
We have previously shown that inhibition of the (MAPK) extracellular-regulated kinase 1/2 (ERK1/2) pathway has a similar beneficial effect on ET receptor alterations, ischemic infarction area and neurological score after MCAO as the PKC inhibition in the present study [28].
Regulation (effect) of ET receptor associated with kinase c, middle cerebral artery infarction and infarction
2) Confidence 0.20 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1770924 Disease Relevance 0.67 Pain Relevance 0.30
Endothelin-1 and right-sided heart failure in rats: effects of an endothelin receptor antagonist on the failing right ventricle.
Regulation (effects) of endothelin receptor in ventricle associated with antagonist and myocardial infarction
3) Confidence 0.20 Published 2000 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 11078411 Disease Relevance 1.09 Pain Relevance 0.20
A preliminary meta-analysis found large and homogeneous effects of naloxone on EtOH consumption and heterogeneous effects on the consumption of control liquids.
Regulation (effects) of EtOH associated with narcan
4) Confidence 0.15 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12175467 Disease Relevance 0 Pain Relevance 0.31
In this study we sought to evaluate whether the stimulatory effects of EtOH on mesolimbic dopamine (DA) transmission are affected by the administration of ACD-sequestering agent D-penicillamine (Dp).
Spec (whether) Regulation (affected) of EtOH associated with dopamine
5) Confidence 0.11 Published 2009 Journal Drug Alcohol Depend Section Abstract Doc Link 19070441 Disease Relevance 0 Pain Relevance 0.39
The primary aim of the present study was to assess the effects of GABAergic MSDB lesions on urethane- and locomotion-related HPCtheta, and compare these effects to those of cholinergic MSDB lesions.
Regulation (effects) of HPCtheta associated with gabaergic
6) Confidence 0.10 Published 2005 Journal Hippocampus Section Abstract Doc Link 15630696 Disease Relevance 0 Pain Relevance 0.33
Whether the latter involves functional antagonism or a selective effect on ETA-receptors has not been addressed.
Regulation (effect) of ETA
7) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2879375 Disease Relevance 0.17 Pain Relevance 0.24
Effects of endothelin-1 and the ETA-receptor antagonist, BQ123, on ischemic arrhythmias in anesthetized rats.
Regulation (Effects) of ETA-receptor associated with anesthesia and antagonist
8) Confidence 0.05 Published 1995 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 7596133 Disease Relevance 0.30 Pain Relevance 0.24
In the present study, opioid receptors in the NACC, VTA, and hippocampus were evaluated for their capacity to regulate both EtOH- and saccharin-motivated behaviors in the genetically selected alcohol-preferring (P) rat.
Regulation (regulate) of EtOH in hippocampus associated with ventral tegmentum, nucleus accumbens, hippocampus, opioid receptor and alcohol
9) Confidence 0.04 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14603266 Disease Relevance 0 Pain Relevance 0.84
EtOH delivery and stimulus presentations were controlled by a computer running Med PC IV (Med Associates) software, which also recorded responses on both levers.


Regulation (controlled) of EtOH in levers
10) Confidence 0.01 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2770635 Disease Relevance 0 Pain Relevance 0
In addition to its effects on instrumental EtOH seeking, blocking dopamine D1-like receptors may also affect entries into the fluid delivery receptacle made in response to the EtOH-associated light-noise stimulus.
Regulation (effects) of EtOH associated with dopamine
11) Confidence 0.01 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2770635 Disease Relevance 0 Pain Relevance 0.10

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