INT49975

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Context Info
Confidence 0.47
First Reported 1993
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 34
Total Number 35
Disease Relevance 9.86
Pain Relevance 12.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SLC6A3) cell death (SLC6A3) aging (SLC6A3)
plasma membrane (SLC6A3) transmembrane transport (SLC6A3) cytoplasm (SLC6A3)
Anatomy Link Frequency
striatum 7
neurons 1
spinal cord 1
putamen 1
brain 1
SLC6A3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 1232 100.00 Very High Very High Very High
positron emission tomography 360 100.00 Very High Very High Very High
monoamine 60 100.00 Very High Very High Very High
Pain 33 100.00 Very High Very High Very High
tolerance 7 100.00 Very High Very High Very High
Migraine 25 99.52 Very High Very High Very High
cocaine 54 99.30 Very High Very High Very High
fluoxetine 6 98.88 Very High Very High Very High
antagonist 23 98.64 Very High Very High Very High
isoflurane 32 98.58 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 29 100.00 Very High Very High Very High
Nicotine Addiction 693 99.76 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 295 99.76 Very High Very High Very High
Headache 29 99.52 Very High Very High Very High
Hemolytic Anemia 28 99.48 Very High Very High Very High
Cognitive Disorder 63 99.34 Very High Very High Very High
Syndrome 118 98.64 Very High Very High Very High
Epilepsy 5 98.48 Very High Very High Very High
Stress 18 97.00 Very High Very High Very High
Congenital Anomalies 107 95.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings documenting an association with DAT suggest that DA modulates the responses of the precuneus during VA.
DAT Binding (association) of associated with dopamine
1) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0.05 Pain Relevance 0.20
These findings offer no evidence for an association of the DAT(Int8) with migraine with and without aura and therefore do not implicate the dopamine transporter gene as a modifier of migraine risk.
DAT Binding (association) of associated with epilepsy, dopamine and migraine
2) Confidence 0.47 Published 2007 Journal Eur. J. Neurol. Section Abstract Doc Link 17539957 Disease Relevance 0.98 Pain Relevance 0.87
Though there is some evidence of a scarce DA innervation of the parietal cortices [57], [58] it is more likely that the association between DAT and BOLD responses in precuneus reflects an indirect modulation by DA through thalamo-cortical pathways rather than a direct modulation.
DAT Binding (association) of in parietal associated with dopamine
3) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0 Pain Relevance 0.25
Inasmuch as DAT is the main mechanism for regulating extracellular DA [16], we postulated that the positive association of DAT with inattention reflected lower and shorter DA signals in subjects with higher DAT.
DAT Spec (postulated) Binding (association) of associated with dopamine and attention deficit hyperactivity disorder
4) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0.53 Pain Relevance 0.35
Significant associations between cold pain tolerance and DAT-1 (p=0.008) and MAO-A (p=0.024) polymorphisms were found.
DAT-1 Binding (associations) of associated with pain and tolerance
5) Confidence 0.40 Published 2009 Journal Pain Section Abstract Doc Link 19796878 Disease Relevance 0.81 Pain Relevance 1.25
BACKGROUND: Isoflurane increases extracellular dopamine concentration and causes trafficking of the dopamine transporter (DAT) in transfected cells.
dopamine transporter Binding (trafficking) of associated with dopamine and isoflurane
6) Confidence 0.37 Published 2004 Journal Anesthesiology Section Abstract Doc Link 15505448 Disease Relevance 0 Pain Relevance 0.31
BACKGROUND: Isoflurane increases extracellular dopamine concentration and causes trafficking of the dopamine transporter (DAT) in transfected cells.
DAT Binding (trafficking) of associated with dopamine and isoflurane
7) Confidence 0.37 Published 2004 Journal Anesthesiology Section Abstract Doc Link 15505448 Disease Relevance 0 Pain Relevance 0.31
In addition, the current results confirm the hypothesis that biotinylation can be used to quantitate the extent of disappearance of DAT from the cell surface making dose-response studies and comparisons of DAT internalization with other general anesthetics practical.
DAT Binding (internalization) of
8) Confidence 0.37 Published 2004 Journal Synapse Section Abstract Doc Link 15170819 Disease Relevance 0 Pain Relevance 0.33
Some of these racemic mixtures were resolved to their enantiomers and tested for binding to norepinephrine (NE) transporter (NET), dopamine (DA) transporter (DAT), and alpha(2) receptor.
DAT Binding (binding) of associated with dopamine
9) Confidence 0.36 Published 2003 Journal J. Med. Chem. Section Abstract Doc Link 14640559 Disease Relevance 0 Pain Relevance 0.33
Thus, it is possible that a progressive accumulation of Mn occurred in the striatum that reached concentrations sufficient to interfere with radioligand binding to DAT.
DAT Binding (binding) of in striatum
10) Confidence 0.36 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.14 Pain Relevance 0.27
Previous investigations have shown that the binding of a selective hydrophilic positron emission tomography radiotracer for the dopamine transporter (DAT) (2beta-carbomethoxy-3beta-(4-chlorophenyl)-8-(2-18F-fluoroethyl)nortropane) decreased in monkey striatum during deep isoflurane anesthesia.
DAT Binding (binding) of in striatum associated with anesthesia, dopamine, positron emission tomography and isoflurane
11) Confidence 0.36 Published 2004 Journal Synapse Section Abstract Doc Link 15170819 Disease Relevance 0 Pain Relevance 0.40
Previous investigations have shown that the binding of a selective hydrophilic positron emission tomography radiotracer for the dopamine transporter (DAT) (2beta-carbomethoxy-3beta-(4-chlorophenyl)-8-(2-18F-fluoroethyl)nortropane) decreased in monkey striatum during deep isoflurane anesthesia.
dopamine transporter Binding (binding) of in striatum associated with anesthesia, dopamine, positron emission tomography and isoflurane
12) Confidence 0.36 Published 2004 Journal Synapse Section Abstract Doc Link 15170819 Disease Relevance 0 Pain Relevance 0.40
In radioligand binding assays, 12-hydroxyibogamine was 50-fold more potent at displacing radioligand binding at the 5-HT transporter than at the DA transporter.
DA transporter Binding (binding) of
13) Confidence 0.36 Published 1995 Journal Life Sci. Section Abstract Doc Link 7596224 Disease Relevance 0 Pain Relevance 0.37
Of these, we will only discuss the dopamine transporter in more detail because it has relevance to ADHD in both humans and animals, the association has been replicated in a number of studies, and it has important implications for understanding the mechanism of action of the stimulants and possibly for identifying which individuals are most likely to respond to treatment.
dopamine transporter Binding (discuss) of associated with dopamine and attention deficit hyperactivity disorder
14) Confidence 0.35 Published 2005 Journal Theor Biol Med Model Section Body Doc Link PMC1352384 Disease Relevance 0.24 Pain Relevance 0.50
The negative association between BOLD responses in ventral ACG and striatal DAT, suggests that individuals with higher DAT (weaker DA signals) require accentuated deactivation of the ventral ACG, possibly to minimize interference of irrelevant processing (i.e. anxiety or negative emotions like fear in the MRI scanner), in order to sustain attention [59].
DAT Neg (negative) Binding (association) of in ventral associated with dopamine and anxiety disorder
15) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0.28 Pain Relevance 0.29
We also hypothesized an interaction with cognitive load increases such that higher DAT availability in striatum would be associated with blunted deactivation of DMN regions.


DAT Binding (associated) of in striatum associated with cognitive disorder
16) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699543 Disease Relevance 0.19 Pain Relevance 0.16
Interestingly, despite disagreement regarding the direction of the association of the SLC6A3-9 allele, studies agree that there seems to be a significant interaction between this gene and DRD2-A1 in increasing susceptibility to tobacco use [103,108].
SLC6A3 Binding (association) of
17) Confidence 0.30 Published 2004 Journal Tob Induc Dis Section Body Doc Link PMC2669467 Disease Relevance 0.80 Pain Relevance 0.14
Interestingly, despite disagreement regarding the direction of the association of the SLC6A3-9 allele, studies agree that there seems to be a significant interaction between this gene and DRD2-A1 in increasing susceptibility to tobacco use [103,108].
SLC6A3 Binding (association) of
18) Confidence 0.30 Published 2004 Journal Tob Induc Dis Section Body Doc Link PMC2671538 Disease Relevance 0.80 Pain Relevance 0.14
However, a firm conclusion that chronic Mn results in the loss of DAT and presumably dopamine neuron terminals in the striatum cannot be made because [11C]-nomifensine is not a selective DAT ligand and because Mn can directly inhibit ligand binding to DAT.
DAT Binding (binding) of in striatum associated with dopamine
19) Confidence 0.28 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0 Pain Relevance 0.62
Typically in this type of assay, one wants a low level of nonspecific binding, in the range of 10–15% of total binding. b) [3H]-Mazindol is known to bind to other monoaminergic uptake sites besides DAT (May et al. 1994).
DAT Binding (bind) of associated with monoamine
20) Confidence 0.27 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0 Pain Relevance 0.30

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