INT49984

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Context Info
Confidence 0.77
First Reported 1994
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.61
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Il1a) extracellular space (Il1a) extracellular region (Il1a)
Il1a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 13 100.00 Very High Very High Very High
Paracetamol 27 99.36 Very High Very High Very High
cINOD 2 84.24 Quite High
antagonist 2 80.24 Quite High
Inflammatory response 2 76.32 Quite High
ketamine 1 62.08 Quite High
anesthesia 2 56.84 Quite High
Disease Link Frequency Relevance Heat
Poisoning 3 99.16 Very High Very High Very High
Fever 2 99.16 Very High Very High Very High
Infection 10 99.08 Very High Very High Very High
Hepatotoxicity 9 96.96 Very High Very High Very High
Sepsis 4 96.72 Very High Very High Very High
Endotoxemia 4 96.32 Very High Very High Very High
Necrosis 5 93.56 High High
Cancer 3 93.20 High High
Sprains And Strains 3 84.12 Quite High
INFLAMMATION 4 84.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that TNF-alpha and IL-1 alpha are released in response to APAP intoxication and are responsible for certain pathological manifestations of APAP-induced hepatotoxicity.
Localization (released) of IL-1 alpha associated with paracetamol, hepatotoxicity and poisoning
1) Confidence 0.77 Published 1995 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7597709 Disease Relevance 0.39 Pain Relevance 0.65
Hyperthermia induces IL-1 alpha but does not decrease release of IL-1 alpha or TNF-alpha after endotoxin.
Localization (release) of IL-1 alpha associated with fever
2) Confidence 0.69 Published 1994 Journal Lymphokine Cytokine Res. Section Title Doc Link 7858059 Disease Relevance 0.86 Pain Relevance 0.15
Neutralization of TNF-alpha or IL-1 alpha with specific antibodies partially prevented the hepatotoxic effects of APAP at the 4- and 8-hr time points.
Localization (Neutralization) of IL-1 alpha associated with paracetamol
3) Confidence 0.69 Published 1996 Journal Toxicol Pathol Section Abstract Doc Link 8992608 Disease Relevance 0.72 Pain Relevance 0.82
This protective effect of LPS appears to be mediated through the release of cytokines such as IL-1 alpha, which in turn suppresses the cytochrome P450 responsible for the activation of acetaminophen and CCl(4) to reactive metabolites.
Localization (release) of IL-1 alpha associated with paracetamol and cytokine
4) Confidence 0.45 Published 2000 Journal Toxicology Section Abstract Doc Link 10924799 Disease Relevance 0.46 Pain Relevance 0.54
The kinetics of the cytokine production varied from one another, with an immediate release of peak levels of IL-1 alpha within 24 hours after infection which did not begin to approach baseline until 9 to 11 days after infection.
Localization (release) of IL-1 alpha associated with infection and cytokine
5) Confidence 0.28 Published 1994 Journal J Ocul Pharmacol Section Abstract Doc Link 8207331 Disease Relevance 1.17 Pain Relevance 0.25

General Comments

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