INT49985

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Context Info
Confidence 0.72
First Reported 1995
Last Reported 2011
Negated 0
Speculated 6
Reported most in Body
Documents 62
Total Number 68
Disease Relevance 40.13
Pain Relevance 20.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Anatomy Link Frequency
livers 4
Lung 3
bladders 2
chondrocytes 1
macrophages 1
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 717 100.00 Very High Very High Very High
chemokine 176 100.00 Very High Very High Very High
Inflammatory response 161 100.00 Very High Very High Very High
Nerve growth factor 18 100.00 Very High Very High Very High
Enkephalin 8 99.74 Very High Very High Very High
agonist 47 99.62 Very High Very High Very High
Osteoarthritis 108 99.28 Very High Very High Very High
Hippocampus 71 99.16 Very High Very High Very High
Paracetamol 38 99.14 Very High Very High Very High
Inflammation 1335 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1533 100.00 Very High Very High Very High
Cancer 353 100.00 Very High Very High Very High
Necrosis 73 100.00 Very High Very High Very High
Apoptosis 83 99.58 Very High Very High Very High
Osteoarthritis 109 99.28 Very High Very High Very High
Obesity 37 99.00 Very High Very High Very High
Rheumatoid Arthritis 448 98.80 Very High Very High Very High
Leukemia 14 98.76 Very High Very High Very High
Hypoxia 267 98.72 Very High Very High Very High
Injury 385 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that IL-6 protein and mRNA levels were considerably higher in quiescent cultured PA-SMCs than in P-ECs (1.5 ± 0.56 vs. 29.3 ± 5 ng/?
Transcription (levels) of IL-6 protein
1) Confidence 0.72 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.63 Pain Relevance 0.08
In contrast, levels of lung IL-6 receptor and gp 130 mRNA, which were markedly increased after 1 week of hypoxia, remained elevated after 2 weeks of hypoxia (Figure 2d).
Transcription (levels) of IL-6 in lung associated with hypoxia
2) Confidence 0.72 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 1.03 Pain Relevance 0
Following the induction of liver injury with acetaminophen (APAP), a time-dependent increase in liver mRNA expression of IL-6 and its family members IL-11, leukemia inhibitory factor, and oncostatin M was observed in wild type (WT) mice, suggesting a possible hepatoprotective role played by this cytokine family.
Transcription (expression) of IL-6 in liver associated with leukemia, paracetamol, injury and cytokine
3) Confidence 0.70 Published 2003 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 12705907 Disease Relevance 0.58 Pain Relevance 0.46
induces transcription of a panel of genes, including IL-6 and RANTES, whereas NF?
Transcription (transcription) of IL-6
4) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.08 Pain Relevance 0.09
After reverse transcription of mRNA (1 µg), the cDNA produced was analyzed for IL-6, IL-1?
Spec (analyzed) Transcription (analyzed) of IL-6
5) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0 Pain Relevance 0.03
Model calibration was adequate after the addition of IL-6, white cell count, and CRP.
Transcription (addition) of IL-6
6) Confidence 0.69 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2730573 Disease Relevance 0.53 Pain Relevance 0.04
The NRI after the addition of IL-6 to the six simple variable model (5%, p?
Transcription (addition) of IL-6
7) Confidence 0.69 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2730573 Disease Relevance 0.20 Pain Relevance 0.03
In addition, the mRNA expressions of other proinflammatory cytokines, interleukin 6 (Il6) and tumor necrosis factor alpha (Tnfalpha) were examined.
Spec (examined) Transcription (expressions) of Il6 associated with necrosis, cancer and cytokine
8) Confidence 0.62 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16413968 Disease Relevance 0.26 Pain Relevance 0.81
In addition, the mRNA expressions of other proinflammatory cytokines, interleukin 6 (Il6) and tumor necrosis factor alpha (Tnfalpha) were examined.
Spec (examined) Transcription (expressions) of interleukin 6 associated with necrosis, cancer and cytokine
9) Confidence 0.62 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16413968 Disease Relevance 0.26 Pain Relevance 0.81
Cyclosporine is a calcineurin inhibitor that was reported to increase IL-6 production and IL-6 mRNA expression [24].
Transcription (expression) of IL-6
10) Confidence 0.62 Published 2010 Journal BMC Dermatol Section Body Doc Link PMC2860341 Disease Relevance 0.69 Pain Relevance 0.20
IL-6, in the presence of sIL-6R, induced TIMP-1 mRNA and protein expression in cultured human chondrocytes and synovial fibroblasts [58].
Transcription (expression) of IL-6 in chondrocytes
11) Confidence 0.62 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2789585 Disease Relevance 0.64 Pain Relevance 0.03
This was, however, associated with increased mRNA expression for IL-1beta and IL-6 and increased serum corticosterone levels.
Transcription (expression) of IL-6
12) Confidence 0.60 Published 1996 Journal J. Immunol. Section Abstract Doc Link 8955229 Disease Relevance 0.80 Pain Relevance 0.39
Liver mRNA expression of tumor necrosis factor-alpha (TNF-alpha) and IL-6 were measured as pro- and anti-inflammatory cytokines, respectively.
Transcription (expression) of IL-6 in Liver associated with necrosis, inflammation, cancer and cytokine
13) Confidence 0.59 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19014921 Disease Relevance 1.34 Pain Relevance 0.81
B activation, which regulates IL-6 and MCP-1 transcription.
Transcription (transcription) of IL-6
14) Confidence 0.56 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 0.83 Pain Relevance 0.26
The high IL-6-inducing activity found in samples before treatment was strongly reduced in samples obtained 4 hours after the first infusion, following TNF-?
Transcription (found) of IL-6-inducing
15) Confidence 0.53 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064892 Disease Relevance 0.12 Pain Relevance 0.28
Neither anti-IL-6 antibody nor rhuIFN alpha had a direct growth-inhibitory effect on the AB22 mesothelioma cell line in vitro, however, in vivo rhuIFN alpha treatment of mice inoculated with AB22 cells attenuated both IL-6 mRNA expression in the tumours and serum IL-6 levels, ameliorated the depression of lymphocyte activities, and enhanced the number of tumour-infiltrating lymphocytes and macrophages.
Transcription (expression) of IL-6 in macrophages associated with lung cancer, depression and cancer
16) Confidence 0.53 Published 1995 Journal Cancer Immunol. Immunother. Section Abstract Doc Link 7750122 Disease Relevance 1.09 Pain Relevance 0.16
A panel of human and murine mesothelioma cell lines was assayed for endogenous IL-6 production in a bioassay, and for IL-6-mRNA expression.
Transcription (expression) of IL-6 associated with lung cancer
17) Confidence 0.53 Published 1995 Journal Cancer Immunol. Immunother. Section Abstract Doc Link 7750122 Disease Relevance 1.44 Pain Relevance 0.03
We demonstrate that methionine-enkephalin (met-enkephalin) stimulates IL-6 mRNA expression in mice as determined by RNA isolation and hybridization with IL-6 cDNA.
Transcription (expression) of IL-6 associated with enkephalin
18) Confidence 0.51 Published 1998 Journal Int. J. Cardiol. Section Abstract Doc Link 9687093 Disease Relevance 0 Pain Relevance 0.68
Instead, Kupffer cell depletion by liposome/clodronate led to significant decreases in the levels of hepatic mRNA expression of several hepato-regulatory cytokines and mediators, including IL-6, IL-10, IL-18 binding protein and complement 1q, suggesting that Kupffer cells are a significant source for production of these mediators in this model.
Transcription (expression) of IL-6 in Kupffer cell associated with cytokine
19) Confidence 0.50 Published 2002 Journal Chem. Res. Toxicol. Section Abstract Doc Link 12482232 Disease Relevance 0.36 Pain Relevance 0.58
For example, interleukin 6 (IL6) mRNA, which is robustly expressed at wild-type wound sites, is almost undetectable in PU.1 null wounds, and TGF?
Transcription (mRNA) of IL6 associated with injury
20) Confidence 0.50 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 0.98 Pain Relevance 0.26

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