INT49986

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Context Info
Confidence 0.72
First Reported 1995
Last Reported 2010
Negated 0
Speculated 4
Reported most in Abstract
Documents 25
Total Number 29
Disease Relevance 18.30
Pain Relevance 16.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tnf) signal transduction (Tnf) extracellular space (Tnf)
extracellular region (Tnf) plasma membrane (Tnf) intracellular (Tnf)
Anatomy Link Frequency
Liver 5
connective tissue 2
Spleen 1
peritoneal macrophages 1
sciatic nerve 1
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 78 100.00 Very High Very High Very High
Inflammation 36 100.00 Very High Very High Very High
antagonist 10 99.96 Very High Very High Very High
rheumatoid arthritis 7 99.92 Very High Very High Very High
Morphine 30 99.70 Very High Very High Very High
Sciatic nerve 5 99.36 Very High Very High Very High
Hyperalgesia 5 99.08 Very High Very High Very High
fluoxetine 18 99.04 Very High Very High Very High
agonist 5 99.04 Very High Very High Very High
Eae 5 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 44 100.00 Very High Very High Very High
Cancer 35 100.00 Very High Very High Very High
Necrosis 28 100.00 Very High Very High Very High
Rheumatoid Arthritis 8 100.00 Very High Very High Very High
Wallerian Degeneration 16 99.12 Very High Very High Very High
Hyperalgesia 9 99.08 Very High Very High Very High
Injury 26 98.80 Very High Very High Very High
Fibrosarcoma 2 97.68 Very High Very High Very High
Pressure And Volume Under Development 5 97.44 Very High Very High Very High
Multiple Sclerosis 3 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to rapid-WD, the production of TNFalpha, IL-1alpha, and IL-1beta protein was deficient in slow-WD, although their mRNAs were expressed. mRNA expression and protein production of TNFalpha, IL-1alpha, and IL-1beta were differentially regulated during rapid-WD and slow-WD, suggesting that mRNA expression, by itself, is no indication of the functional involvement of cytokines in WD.
Transcription (expression) of TNFalpha associated with wallerian degeneration and cytokine
1) Confidence 0.72 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11943808 Disease Relevance 1.32 Pain Relevance 0.26
Spleen cells from withdrawn mice also showed decreased mRNA levels of IL-1beta, IL-1-Ra, and TNF-alpha and a suppression of co-stimulatory molecule expression.
Transcription (levels) of TNF-alpha in Spleen associated with rheumatoid arthritis
2) Confidence 0.69 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 14741440 Disease Relevance 0.10 Pain Relevance 0.29
RESULTS: Morphine induced TNF-alpha mRNA expression via dopamine and opioid receptors.
Transcription (expression) of TNF-alpha mRNA
3) Confidence 0.69 Published 2007 Journal Biol. Psychiatry Section Body Doc Link 17217924 Disease Relevance 0 Pain Relevance 0
Liver mRNA expression of tumor necrosis factor-alpha (TNF-alpha) and IL-6 were measured as pro- and anti-inflammatory cytokines, respectively.
Transcription (expression) of tumor necrosis factor-alpha in Liver associated with necrosis, inflammation, cancer and cytokine
4) Confidence 0.68 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19014921 Disease Relevance 1.33 Pain Relevance 0.81
Liver mRNA expression of tumor necrosis factor-alpha (TNF-alpha) and IL-6 were measured as pro- and anti-inflammatory cytokines, respectively.
Transcription (expression) of TNF-alpha in Liver associated with necrosis, inflammation, cancer and cytokine
5) Confidence 0.68 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19014921 Disease Relevance 1.34 Pain Relevance 0.81
In addition, the levels of mRNA transcripts for IL-1 alpha, IL-6, and TNF-alpha from livers of treated mice were examined by reverse transcription-polymerase chain reaction (RT-PCR).
Spec (examined) Transcription (levels) of TNF-alpha in livers
6) Confidence 0.68 Published 1995 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7597709 Disease Relevance 0.33 Pain Relevance 0.70
Prescription of TNFalpha antagonists is controlled, according local restrictions, regarding high costs of the therapy.
Transcription (Prescription) of TNFalpha associated with antagonist
7) Confidence 0.68 Published 2008 Journal Reumatizam Section Abstract Doc Link 19024266 Disease Relevance 0.93 Pain Relevance 0.52
In addition, the mRNA expressions of other proinflammatory cytokines, interleukin 6 (Il6) and tumor necrosis factor alpha (Tnfalpha) were examined.
Spec (examined) Transcription (expressions) of tumor necrosis factor alpha associated with necrosis, cancer and cytokine
8) Confidence 0.62 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16413968 Disease Relevance 0.26 Pain Relevance 0.81
Cerulein treatment increased mRNA expression of several proinflammatory cytokines (TNFalpha, IL-1beta, and IL-6) at 12 h with similar magnitude both in wild-type and PACAP-Tg mice.
Transcription (expression) of TNFalpha associated with cytokine
9) Confidence 0.58 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19672038 Disease Relevance 0.93 Pain Relevance 0.27
Morphine enhanced mRNA expression of interleukin (IL)-12 p40 and tumor necrosis factor alpha (TNF-alpha) compared with controls, whereas IL-10 levels were unchanged by drug treatment.
Transcription (expression) of tumor necrosis factor alpha associated with necrosis, cancer and morphine
10) Confidence 0.56 Published 2000 Journal J. Leukoc. Biol. Section Abstract Doc Link 11073113 Disease Relevance 0.28 Pain Relevance 1.06
Morphine enhanced mRNA expression of interleukin (IL)-12 p40 and tumor necrosis factor alpha (TNF-alpha) compared with controls, whereas IL-10 levels were unchanged by drug treatment.
Transcription (expression) of TNF-alpha associated with necrosis, cancer and morphine
11) Confidence 0.56 Published 2000 Journal J. Leukoc. Biol. Section Abstract Doc Link 11073113 Disease Relevance 0.28 Pain Relevance 1.06
To investigate the very early temporal pattern of cytokine regulation we studied 140 mice of C57Bl/6J background after chronic constriction injury (CCI) of the right sciatic nerve and measured the relative mRNA expression of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF) and interleukin-1beta (IL-1beta) and of the anti-inflammatory cytokines IL-4 and IL-10 with quantitative real-time polymerase chain reaction (qRT-PCR).
Transcription (expression) of tumor necrosis factor-alpha in sciatic nerve associated with necrosis, inflammation, cancer, eae, injury, sciatic nerve and cytokine
12) Confidence 0.55 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17204395 Disease Relevance 1.08 Pain Relevance 0.72
In addition, the mRNA expressions of other proinflammatory cytokines, interleukin 6 (Il6) and tumor necrosis factor alpha (Tnfalpha) were examined.
Spec (examined) Transcription (expressions) of Tnfalpha associated with necrosis, cancer and cytokine
13) Confidence 0.54 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16413968 Disease Relevance 0.26 Pain Relevance 0.81
The presence of TNF-alpha mRNA was confirmed in tumor site homogenates by reverse transcription-polymerase chain reaction (RT-PCR), and examination of TNF-alpha protein levels in tumor-bearing mice indicated a significantly higher concentration of this cytokine in tumor microperfusates and tumor site homogenates compared with that obtained from a similar site on the contralateral limb or in naive mice.
Transcription (presence) of TNF-alpha in limb associated with cancer and cytokine
14) Confidence 0.53 Published 2005 Journal Neuroscience Section Abstract Doc Link 15802198 Disease Relevance 1.50 Pain Relevance 0.17
In this study, non- elicited peritoneal macrophages were treated simultaneously with the kappa-agonist U50,488H and lipopolysaccharide (LPS), and the levels of the cytokines interleukin (IL)-1, IL-6 and tumor necrosis factor (TNF)-alpha were determined.
Spec (determined) Transcription (levels) of tumor necrosis factor in peritoneal macrophages associated with necrosis, cancer, agonist and cytokine
15) Confidence 0.52 Published 1996 Journal J. Neuroimmunol. Section Abstract Doc Link 8598393 Disease Relevance 0.20 Pain Relevance 0.80
The impact of these compounds on mRNA expression of GPX, TNF-alpha, and MCP-1 indicated that these compounds could act at a transcription level.
Transcription (expression) of TNF-alpha
16) Confidence 0.52 Published 2009 Journal J. Food Sci. Section Abstract Doc Link 19799668 Disease Relevance 0.44 Pain Relevance 0.58
ME10092 dose-dependently inhibited LPS-induced nuclear translocation of NF-kappaB, transcription of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
Transcription (transcription) of TNF-alpha associated with necrosis and cancer
17) Confidence 0.51 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20074673 Disease Relevance 0.52 Pain Relevance 0.24
In addition, the levels of mRNA transcripts for IL-1 alpha, IL-6, and TNF-alpha from livers of treated mice were examined by reverse transcription-polymerase chain reaction (RT-PCR).
Transcription (transcripts) of TNF-alpha in livers
18) Confidence 0.51 Published 1995 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 7597709 Disease Relevance 0.33 Pain Relevance 0.70
Expression of mRNA for tumor necrosis factor-alpha (TNF-alpha), interleukin-10 (IL-10), matrix metalloproteinase-9, and connective tissue growth factor (CTGF) also increased in the liver following acetaminophen treatment of wild-type mice.
Transcription (Expression) of tumor necrosis factor-alpha in connective tissue associated with necrosis, paracetamol, cancer and metalloproteinase
19) Confidence 0.50 Published 2002 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12392966 Disease Relevance 1.15 Pain Relevance 0.69
Expression of mRNA for tumor necrosis factor-alpha (TNF-alpha), interleukin-10 (IL-10), matrix metalloproteinase-9, and connective tissue growth factor (CTGF) also increased in the liver following acetaminophen treatment of wild-type mice.
Transcription (Expression) of TNF-alpha in connective tissue associated with necrosis, paracetamol, cancer and metalloproteinase
20) Confidence 0.50 Published 2002 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12392966 Disease Relevance 1.15 Pain Relevance 0.69

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