INT49991

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Context Info
Confidence 0.40
First Reported 1995
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.03
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lta) extracellular region (Lta)
Anatomy Link Frequency
natural killer cell 4
MNC 2
Lta (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 4 100.00 Very High Very High Very High
Peripheral nervous system 3 98.98 Very High Very High Very High
Neuritis 9 98.10 Very High Very High Very High
aspirin 1 95.60 Very High Very High Very High
cINOD 6 95.40 Very High Very High Very High
Demyelination 1 91.76 High High
Inflammation 1 91.04 High High
Inflammatory response 1 86.12 High High
Central grey 4 50.00 Quite Low
Morphine 4 50.00 Quite Low
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 9 98.10 Very High Very High Very High
Reprotox - General 1 5 96.08 Very High Very High Very High
Disease 5 93.28 High High
Demyelinating Disease 1 91.76 High High
INFLAMMATION 4 91.04 High High
Syndrome 1 89.80 High High
Urological Neuroanatomy 6 81.96 Quite High
Convalescence 1 75.00 Quite High
Immunization 1 68.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate this, the authors undertook a case-control study (n = 1,012) of the association between NSAIDs and more advanced prostate cancer in Ohio men recruited between 2001 and 2004 and evaluated whether this association was modified by a functional polymorphism in the lymphotoxin alpha (LTA) gene (LTA C+80A, where the CC genotype results in higher LTA production).
Positive_regulation (results) of Gene_expression (production) of LTA associated with cinod and reprotox - general 1
1) Confidence 0.40 Published 2006 Journal Am. J. Epidemiol. Section Abstract Doc Link 16931544 Disease Relevance 0.73 Pain Relevance 0.47
RESULTS: Microinjection of morphine (0.5 microL, 3672 ng) into PAG region had no influence on IL-6 and TNF-alpha (production of splenic macrophages, suppressed the natural killer cell (NK) activity and enhanced T-lymphocyte functions, including concanavalin A (Con A)-induced T-cell proliferation, IL-2 and TNF-beta production.
Positive_regulation (enhanced) of Gene_expression (production) of TNF-beta in natural killer cell
2) Confidence 0.18 Published 1995 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 7597910 Disease Relevance 0.16 Pain Relevance 0
RESULTS: Intrathecal morphine inhibited splenic NK cell activity, IL-2 production, TNF-beta activity, and increased in serum ACTH level.
Positive_regulation (increased) of Gene_expression (production) of TNF-beta in NK cell
3) Confidence 0.15 Published 1998 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 10437136 Disease Relevance 0.15 Pain Relevance 0
To study the involvement of immunoregulatory cytokines, we induced EAN in Lewis rats by immunizing with bovine PNS myelin (BPM) and Freund's complete adjuvant. mRNA expression of the cytokines IL-1beta, IL-6, IL-10, IL-12, TNF-alpha and TNF-beta, and the cytolytic effector molecule cytolysin was examined in lymph node mononuclear cells (MNC) over the course of EAN by in situ hybridization after culture without antigen and in the presence of BPM, the myelin P2 protein, the control antigen acetylcholine receptor, or the mitogen PHA.
Positive_regulation (examined) of Gene_expression (expression) of TNF-beta in MNC associated with peripheral nervous system, neuritis and cytokine
4) Confidence 0.06 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9307234 Disease Relevance 0.99 Pain Relevance 0.95

General Comments

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