INT49992

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Context Info
Confidence 0.47
First Reported 1995
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.80
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lta) extracellular region (Lta)
Anatomy Link Frequency
natural killer cell 2
Lta (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 20 99.34 Very High Very High Very High
cytokine 26 98.80 Very High Very High Very High
Central nervous system 6 81.88 Quite High
Neuritis 2 64.72 Quite High
imagery 2 59.60 Quite High
Central grey 4 50.00 Quite Low
Morphine 4 50.00 Quite Low
narcan 2 50.00 Quite Low
intrathecal 2 50.00 Quite Low
Inflammation 4 46.64 Quite Low
Disease Link Frequency Relevance Heat
Necrosis 3 100.00 Very High Very High Very High
Cancer 3 100.00 Very High Very High Very High
Demyelinating Disease 20 99.34 Very High Very High Very High
Myocardial Infarction 39 98.96 Very High Very High Very High
Coronary Heart Disease 24 86.48 High High
Urological Neuroanatomy 6 81.96 Quite High
Congenital Anomalies 4 72.24 Quite High
Disorder Of Lipid Metabolism 8 71.04 Quite High
Obesity 3 68.56 Quite High
Optic Neuritis 2 65.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
None of the individual haplotypes for the LTA gene was associated with MI risk (?
Positive_regulation (haplotypes) of LTA associated with myocardial infarction
1) Confidence 0.47 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1487176 Disease Relevance 0.63 Pain Relevance 0
RESULTS: Intrathecal morphine inhibited splenic NK cell activity, IL-2 production, TNF-beta activity, and increased in serum ACTH level.
Positive_regulation (increased) of TNF-beta in NK cell
2) Confidence 0.20 Published 1998 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 10437136 Disease Relevance 0.15 Pain Relevance 0
RESULTS: Microinjection of morphine (0.5 microL, 3672 ng) into PAG region had no influence on IL-6 and TNF-alpha (production of splenic macrophages, suppressed the natural killer cell (NK) activity and enhanced T-lymphocyte functions, including concanavalin A (Con A)-induced T-cell proliferation, IL-2 and TNF-beta production.
Positive_regulation (enhanced) of TNF-beta in natural killer cell
3) Confidence 0.08 Published 1995 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 7597910 Disease Relevance 0.16 Pain Relevance 0
A preferential up-modulation of TNF-alpha and lymphotoxin-alpha is observed in clinical exacerbations and of TGF-beta and IL-10 in remissions.
Positive_regulation (up-modulation) of lymphotoxin-alpha
4) Confidence 0.02 Published 1996 Journal J. Neurosci. Res. Section Abstract Doc Link 8872892 Disease Relevance 1.04 Pain Relevance 0.81
MS is associated with the parallel up-regulation of proinflammatory [interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), lymphotoxin-alpha, and interleukin (IL)-12] and immune response-down-regulating [transforming growth factor-beta (TGF-beta), IL-10] cytokines systemically.
Positive_regulation (up-regulation) of lymphotoxin-alpha associated with necrosis, multiple sclerosis, cancer and cytokine
5) Confidence 0.02 Published 1996 Journal J. Neurosci. Res. Section Abstract Doc Link 8872892 Disease Relevance 0.82 Pain Relevance 0.65

General Comments

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