INT49993

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Context Info
Confidence 0.70
First Reported 1993
Last Reported 2011
Negated 5
Speculated 7
Reported most in Abstract
Documents 149
Total Number 156
Disease Relevance 88.07
Pain Relevance 53.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
Anatomy Link Frequency
macrophages 13
monocyte 13
lung 12
plasma 10
spinal cord 8
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 1144 100.00 Very High Very High Very High
cytokine 758 100.00 Very High Very High Very High
Spinal cord 81 100.00 Very High Very High Very High
Inflammatory mediators 77 100.00 Very High Very High Very High
Eae 33 100.00 Very High Very High Very High
Chronic pancreatitis 14 100.00 Very High Very High Very High
allodynia 13 100.00 Very High Very High Very High
Intracerebroventricular 12 100.00 Very High Very High Very High
Hyperalgesia 9 100.00 Very High Very High Very High
neuralgia 8 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1360 100.00 Very High Very High Very High
Injury 258 100.00 Very High Very High Very High
Cancer 167 100.00 Very High Very High Very High
Necrosis 91 100.00 Very High Very High Very High
Neuropathic Pain 70 100.00 Very High Very High Very High
Pancreatitis 20 100.00 Very High Very High Very High
Hyperalgesia 20 100.00 Very High Very High Very High
Obesity 296 99.98 Very High Very High Very High
Diabetes Mellitus 176 99.98 Very High Very High Very High
Hyperoxia 102 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the current study, our objective was to determine if the source of IL-6 protein was endogenous to the central nervous system by measuring any detectable increases in spinal IL-6 mRNA expression following established mononeuropathy procedures associated with neuropathic pain: spinal nerve cryoneurolysis (SPCN) or spinal nerve tight ligation (SPTL).
Positive_regulation (increases) of Gene_expression (expression) of IL-6 mRNA in spinal nerve associated with neuropathic pain, central nervous system and diabetic nephropathy
1) Confidence 0.70 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9813345 Disease Relevance 0.68 Pain Relevance 0.62
Peripheral nerve lesion leads to the production of interleukin 6 (IL-6)-related neuropoietic cytokines involved in nerve protection and regeneration.
Positive_regulation (leads) of Gene_expression (production) of interleukin 6 in Peripheral nerve associated with cytokine
2) Confidence 0.67 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18636982 Disease Relevance 0.36 Pain Relevance 0.48
It may also contribute to the vascular inflammation associated with atherogenesis by increasing the synthesis of Interleukin-6 in vascular smooth muscle cells.
Positive_regulation (increasing) of Gene_expression (synthesis) of Interleukin-6 in smooth muscle cells associated with inflammation, atherosclerosis and vasculitis
3) Confidence 0.66 Published 2006 Journal Nutr Metab Cardiovasc Dis Section Abstract Doc Link 16580588 Disease Relevance 0.74 Pain Relevance 0.27
Semiquantitative PCR revealed that E-selectin and IL-6 gene expressions were increased in rats following LPS injection, and an overdose of tamoxifen, an estrogen receptor antagonist, reversed the effect of 17beta-estradiol on E-selectin, but not its effect on IL-6.
Positive_regulation (increased) of Gene_expression (expressions) of IL-6 associated with antagonist and overdose
4) Confidence 0.63 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10384138 Disease Relevance 0.90 Pain Relevance 0.19
Although MV with a VT of 6 or 20 ml/kg did not significantly change IL6 gene expression (p = 0.146), significant differences were found between spontaneous breathing and high VT groups (p = 0.033) (Figure 2A).
Neg (not) Positive_regulation (change) of Gene_expression (expression) of IL6
5) Confidence 0.60 Published 2010 Journal Respir Res Section Body Doc Link PMC2841148 Disease Relevance 0.33 Pain Relevance 0.13
A 35-year-old Japanese woman presented with a phaeochromocytoma and demonstrated marked inflammatory reactions and pyrexia as a result of excessive production of interleukin-6 (IL-6) by the tumour.
Positive_regulation (result) of Gene_expression (production) of interleukin-6 associated with inflammation, cancer, fever and pheochromocytoma
6) Confidence 0.59 Published 2001 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 11298095 Disease Relevance 1.09 Pain Relevance 0.32
At least 100 mg/ml Cara was necessary for detection of IL-6 (2.03+/-0.1 ng/ml) and TNFalpha (0.6+0.09 ng/ml) in PEC.
Positive_regulation (necessary) of Gene_expression (detection) of IL-6
7) Confidence 0.56 Published 2004 Journal Int. Immunopharmacol. Section Abstract Doc Link 15182729 Disease Relevance 1.16 Pain Relevance 0.54
The IL-6 exerting this effect during exercise could be produced by the brain itself, which has been shown to have increased IL-6 production during exercise [58].
Positive_regulation (increased) of Gene_expression (production) of IL-6 in brain
8) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0
Following the 0.3 mg/kg/h infusion, IL-6 expression is increased and maintained at a high level throughout the long-term treatment period.
Positive_regulation (increased) of Gene_expression (expression) of IL-6
9) Confidence 0.55 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0
Thus it is reasonable to assume that increased expression of IL-6 receptor potentially enhances muscle sensitivity to IL-6 and augments the inhibitory effect of IL-6 on IRS-1 transcription.
Positive_regulation (increased) of Gene_expression (expression) of IL-6 in muscle
10) Confidence 0.55 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0.41 Pain Relevance 0.20
It is likely that emboli in the lung trigger an inflammatory reaction, which takes time to become established before IL-6 levels increase.
Positive_regulation (increase) of Gene_expression (levels) of IL-6 in lung associated with inflammation
11) Confidence 0.50 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2702344 Disease Relevance 0.77 Pain Relevance 0.23
Suppression of interleukin-6 by minocycline in a rat model of neuropathic pain.
Positive_regulation (Suppression) of Gene_expression (Suppression) of interleukin-6 associated with neuralgia and neuropathic pain
12) Confidence 0.50 Published 2006 Journal Eur. J. Pharmacol. Section Title Doc Link 16687137 Disease Relevance 0.91 Pain Relevance 1.23
Interleukin-6-mediated hyperalgesia/allodynia and increased spinal IL-6 expression in a rat mononeuropathy model.
Positive_regulation (increased) of Gene_expression (expression) of IL-6 in spinal associated with hyperalgesia, allodynia and diabetic nephropathy
13) Confidence 0.50 Published 1996 Journal J. Interferon Cytokine Res. Section Title Doc Link 8887053 Disease Relevance 0.78 Pain Relevance 0.75
Hyperthermia significantly increased the production of IL-6 (p = 0.049) but not IL-1beta and significantly increased mortality.
Positive_regulation (increased) of Gene_expression (production) of IL-6 associated with fever
14) Confidence 0.50 Published 2002 Journal Pediatr. Res. Section Abstract Doc Link 12438666 Disease Relevance 0.70 Pain Relevance 0.27
Administration of MDP significantly increased the IL-1beta production (p = 0.006) but not IL-6.
Neg (not) Positive_regulation (increased) of Gene_expression (production) of IL-6
15) Confidence 0.50 Published 2002 Journal Pediatr. Res. Section Abstract Doc Link 12438666 Disease Relevance 0.58 Pain Relevance 0.24
Further study is warranted to clarify the role of IL-6 in tumor-related symptoms and the effect of steroid therapy in relation to IL-6 production in cancer patients.
Positive_regulation (relation) of Gene_expression (production) of IL-6 associated with cancer
16) Confidence 0.50 Published 1996 Journal J Pain Symptom Manage Section Abstract Doc Link 8803383 Disease Relevance 0.78 Pain Relevance 0.16
A 35-year-old Japanese woman presented with a phaeochromocytoma and demonstrated marked inflammatory reactions and pyrexia as a result of excessive production of interleukin-6 (IL-6) by the tumour.
Positive_regulation (excessive) of Gene_expression (production) of IL-6 associated with inflammation, cancer, fever and pheochromocytoma
17) Confidence 0.49 Published 2001 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 11298095 Disease Relevance 1.10 Pain Relevance 0.32
Expression of tumor necrosis factor-alpha, interleukin-6, and interferon-gamma in spontaneous chronic pancreatitis in the WBN/Kob rat.
Positive_regulation (pancreatitis) of Gene_expression (Expression) of interleukin-6 associated with necrosis, cancer and chronic pancreatitis
18) Confidence 0.49 Published 2001 Journal Pancreas Section Title Doc Link 11345142 Disease Relevance 1.12 Pain Relevance 0.71
Peripheral nerve lesion leads to the production of interleukin 6 (IL-6)-related neuropoietic cytokines involved in nerve protection and regeneration.
Positive_regulation (leads) of Gene_expression (production) of IL-6 in Peripheral nerve associated with cytokine
19) Confidence 0.49 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18636982 Disease Relevance 0.36 Pain Relevance 0.48
The role of PGE2 in production of IL-6 by AM is further confirmed by restoration of IL-6 release in AM with 0.5 ?
Positive_regulation (by) of Gene_expression (production) of IL-6
20) Confidence 0.48 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2806337 Disease Relevance 0.29 Pain Relevance 0.18

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