INT49994

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.64
First Reported 1995
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 6.94
Pain Relevance 2.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lta) extracellular region (Lta)
Anatomy Link Frequency
natural killer cell 2
MNC 2
plaques 1
TMJ 1
immune system 1
Lta (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 30 100.00 Very High Very High Very High
Inflammatory response 7 99.92 Very High Very High Very High
Peripheral nervous system 6 98.98 Very High Very High Very High
Neuritis 18 98.84 Very High Very High Very High
Inflammation 9 96.28 Very High Very High Very High
aspirin 1 95.60 Very High Very High Very High
cINOD 6 95.04 Very High Very High Very High
Demyelination 2 91.76 High High
pulpitis 1 78.88 Quite High
Central grey 6 50.00 Quite Low
Disease Link Frequency Relevance Heat
Atherosclerotic Plaque 6 99.84 Very High Very High Very High
INFLAMMATION 18 99.56 Very High Very High Very High
Experimental Autoimmune Neuritis 18 98.84 Very High Very High Very High
Adhesions 6 98.24 Very High Very High Very High
Injury 3 98.08 Very High Very High Very High
Disease 15 97.92 Very High Very High Very High
Increased Venous Pressure Under Development 9 97.00 Very High Very High Very High
Coronary Heart Disease 72 96.20 Very High Very High Very High
Reprotox - General 1 5 95.72 Very High Very High Very High
Immunization 2 95.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LTA is expressed in atherosclerotic plaques and has been implicated in the pathogenesis of atherosclerosis and coronary heart disease (CHD).
Gene_expression (expressed) of LTA in heart associated with atherosclerotic plaque, coronary heart disease and increased venous pressure under development
1) Confidence 0.64 Published 2006 Journal PLoS Genetics Section Abstract Doc Link PMC1487176 Disease Relevance 0.92 Pain Relevance 0.15
To investigate this, the authors undertook a case-control study (n = 1,012) of the association between NSAIDs and more advanced prostate cancer in Ohio men recruited between 2001 and 2004 and evaluated whether this association was modified by a functional polymorphism in the lymphotoxin alpha (LTA) gene (LTA C+80A, where the CC genotype results in higher LTA production).
Gene_expression (production) of LTA associated with cinod and reprotox - general 1
2) Confidence 0.52 Published 2006 Journal Am. J. Epidemiol. Section Abstract Doc Link 16931544 Disease Relevance 0.72 Pain Relevance 0.46
LTA is expressed in atherosclerotic plaques in animal models, and has been implicated in the pathogenesis of atherosclerosis and coronary heart disease (CHD) [3,4].
Gene_expression (expressed) of LTA in plaques associated with atherosclerotic plaque, coronary heart disease and increased venous pressure under development
3) Confidence 0.49 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1487176 Disease Relevance 1.16 Pain Relevance 0.09
(LTA) is a cytokine produced by all cells in the body in response to tissue injury, and it plays an important role in regulation of the immune system and local inflammatory response [1].
Gene_expression (produced) of LTA in immune system associated with inflammatory response, injury and cytokine
4) Confidence 0.49 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1487176 Disease Relevance 0.85 Pain Relevance 0.10
In contrast, cells expressing IL-1 beta and TNF beta, the homologous forms of these mediators, were not found in pulp or periapical lesions during this period.
Gene_expression (expressing) of TNF beta
5) Confidence 0.36 Published 1995 Journal Oral Microbiol. Immunol. Section Abstract Doc Link 8602333 Disease Relevance 0.53 Pain Relevance 0.30
RESULTS: Microinjection of morphine (0.5 microL, 3672 ng) into PAG region had no influence on IL-6 and TNF-alpha (production of splenic macrophages, suppressed the natural killer cell (NK) activity and enhanced T-lymphocyte functions, including concanavalin A (Con A)-induced T-cell proliferation, IL-2 and TNF-beta production.
Gene_expression (production) of TNF-beta in natural killer cell
6) Confidence 0.27 Published 1995 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 7597910 Disease Relevance 0.16 Pain Relevance 0
METHODS: Rat splenic natural killer (NK) cell activity was determined by a europium release assay; the concanavalin A-induced splenic IL-2 production, TNF-beta activity, and serum TNF-alpha level were determined by colorimetric thiazolyl blue tetrazolium bromide (MTT) and gentian violet assay, and serum corticotrophin (ACTH) level by radio-immunological method after intrathecal injection of morphine and PAG microinjection of naloxone.
Gene_expression (production) of TNF-beta
7) Confidence 0.23 Published 1998 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 10437136 Disease Relevance 0.18 Pain Relevance 0
RESULTS: Intrathecal morphine inhibited splenic NK cell activity, IL-2 production, TNF-beta activity, and increased in serum ACTH level.
Gene_expression (production) of TNF-beta in NK cell
8) Confidence 0.20 Published 1998 Journal Zhongguo Yao Li Xue Bao Section Body Doc Link 10437136 Disease Relevance 0.15 Pain Relevance 0
Three patterns of cytokine mRNA expressing MNC in relation to clinical EAN could be distinguished: (i) IL-1beta mRNA expressing cells peaked already on day 3 post immunization (p.i.), and BPM- and P2-reactive TNF-alpha, and BPM-reactive IL-6 mRNA expressing cells were also detected already on day 7 p.i., i.e., before onset of clinical EAN; (ii) BPM- and P2-reactive TNF-alpha peaked together with P2-reactive TNF-beta, IL-6 and IL-12 mRNA expressing cells at height of clinical EAN, consistent with a disease-promoting role for these four cytokines; (iii) high levels of BPM- and P2-reactive IL-10 and cytolysin mRNA expressing cells were observed only during recovery (day 28 p.i.), consistent with a disease down-regulating role of IL-10 and cytolysin.
Gene_expression (expressing) of TNF-beta in MNC associated with immunization, disease, neuritis and cytokine
9) Confidence 0.08 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9307234 Disease Relevance 1.16 Pain Relevance 1.00
To study the involvement of immunoregulatory cytokines, we induced EAN in Lewis rats by immunizing with bovine PNS myelin (BPM) and Freund's complete adjuvant. mRNA expression of the cytokines IL-1beta, IL-6, IL-10, IL-12, TNF-alpha and TNF-beta, and the cytolytic effector molecule cytolysin was examined in lymph node mononuclear cells (MNC) over the course of EAN by in situ hybridization after culture without antigen and in the presence of BPM, the myelin P2 protein, the control antigen acetylcholine receptor, or the mitogen PHA.
Gene_expression (expression) of TNF-beta in MNC associated with peripheral nervous system, neuritis and cytokine
10) Confidence 0.08 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9307234 Disease Relevance 0.92 Pain Relevance 0.88
DESIGN: In twelve OA of the TMJ (OA-TMJ) affected patients and in six healthy volunteer subjects studied as control, the expression of IL1beta (interleukin-1beta), IL2, IL4, IL5, IL6, IL10, IL12p35, IL12p40, IL17, IFNgamma (interferon-gamma), TNFalpha (tumor necrosis factor-alpha), and TNFbeta mRNAs was evaluated.
Gene_expression (expression) of TNFbeta in TMJ
11) Confidence 0.00 Published 2008 Journal Arch. Oral Biol. Section Body Doc Link 18508030 Disease Relevance 0.19 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox