INT49995

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Context Info
Confidence 0.70
First Reported 1993
Last Reported 2010
Negated 1
Speculated 5
Reported most in Body
Documents 187
Total Number 192
Disease Relevance 125.07
Pain Relevance 70.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
macrophages 24
mononuclear cells 14
DRG 13
gut 10
sciatic nerve 10
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 617 100.00 Very High Very High Very High
cytokine 505 100.00 Very High Very High Very High
Pain 128 100.00 Very High Very High Very High
Inflammatory mediators 115 100.00 Very High Very High Very High
Glutamate 77 100.00 Very High Very High Very High
allodynia 73 100.00 Very High Very High Very High
substance P 36 100.00 Very High Very High Very High
Peripheral nervous system 24 100.00 Very High Very High Very High
Thermal hyperalgesia 23 100.00 Very High Very High Very High
Intracerebroventricular 13 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 811 100.00 Very High Very High Very High
Injury 367 100.00 Very High Very High Very High
Cancer 267 100.00 Very High Very High Very High
Pancreatitis 237 100.00 Very High Very High Very High
Necrosis 213 100.00 Very High Very High Very High
Neuropathic Pain 177 100.00 Very High Very High Very High
Adhesions 144 100.00 Very High Very High Very High
Pain 106 100.00 Very High Very High Very High
Hyperalgesia 87 100.00 Very High Very High Very High
Stress 78 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A significant increase in the expression of TNF-alpha-positive neurons in DRG specimens was observed in both NP graft groups.
Positive_regulation (increase) of Gene_expression (expression) of TNF-alpha in DRG
1) Confidence 0.70 Published 2009 Journal J Neurosurg Spine Section Body Doc Link 19929348 Disease Relevance 0.13 Pain Relevance 0
The increase in TNFalpha expression is specific to discrete regions of the CNS, rather than being the result of a systemic inflammatory response, since TNFalpha bioactivity in plasma is, in fact, decreased in rats undergoing CCI.
Positive_regulation (increase) of Gene_expression (expression) of TNFalpha in plasma
2) Confidence 0.70 Published 2002 Journal Reg Anesth Pain Med Section Body Doc Link 12132059 Disease Relevance 0 Pain Relevance 0
Expression of neuron-associated tumor necrosis factor alpha in the brain is increased during persistent pain.
Positive_regulation (increased) of Gene_expression (Expression) of tumor necrosis factor alpha in brain associated with pain, necrosis, cancer and lasting pain
3) Confidence 0.70 Published 2002 Journal Reg Anesth Pain Med Section Title Doc Link 12132059 Disease Relevance 0.68 Pain Relevance 0.61
An increased TNF-alpha mRNA expression was also observed in LH (46 +/- 8, P < 0.05), LC(30 +/- 3, P < 0.01) and LA(32 +/- 3, P < 0.01) at 6 h which resolved by 24 h following injury.
Positive_regulation (increased) of Gene_expression (expression) of TNF-alpha mRNA associated with injury and hippocampus
4) Confidence 0.70 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8965649 Disease Relevance 0.96 Pain Relevance 0.36
In the contralateral hemisphere, expression of TNF-alpha mRNA was increased in RH (46 +/- 2, P < 0.01) at 1 h and in RA (26 +/- 6%, P < 0.05) at 6 h.
Positive_regulation (increased) of Gene_expression (expression) of TNF-alpha mRNA associated with rheumatoid arthritis and hippocampus
5) Confidence 0.70 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8965649 Disease Relevance 0.90 Pain Relevance 0.33
A marked increase of TNF-alpha mRNA expression was observed in LH (104 +/- 17, P < 0.05 compared with sham), LC (105 +/- 21, P < 0.05) and LA (69 +/- 8, P < 0.01) in the traumatized hemisphere 1 h following injury.
Positive_regulation (increase) of Gene_expression (expression) of TNF-alpha mRNA associated with injury and hippocampus
6) Confidence 0.70 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8965649 Disease Relevance 1.07 Pain Relevance 0.37
RESULTS: In the absence of antiulcer drugs, indomethacin caused extensive multiple hemorrhagic lesions accompanied by a 47% increase in mucosal expression of TNF-alpha and a dramatic (> 300-fold) enhancement in gastric epithelial cell apoptosis.
Positive_regulation (increase) of Gene_expression (expression) of TNF-alpha in epithelial cell
7) Confidence 0.70 Published 1997 Journal Scand. J. Gastroenterol. Section Body Doc Link 9246701 Disease Relevance 0.15 Pain Relevance 0
In contrast, the H2-receptor antagonist ebrotidine, also known for its gastroprotective effects, not only successfully prevented (98.3%) the enhancement in mucosal TNF-alpha expression caused by indomethacin but also caused a 54% reduction in the epithelial cell apoptosis.
Positive_regulation (enhancement) of Gene_expression (expression) of TNF-alpha in epithelial cell
8) Confidence 0.70 Published 1997 Journal Scand. J. Gastroenterol. Section Body Doc Link 9246701 Disease Relevance 0.11 Pain Relevance 0
CONCLUSIONS: Our findings provide new insights into the mechanism of gastric injury caused by NSAIDs and show that ebrotidine protection against indomethacin-induced mucosal damage occurs through the inhibition of epithelial cell apoptosis triggered by the enhancement in the mucosal TNF-alpha expression.
Positive_regulation (enhancement) of Gene_expression (expression) of TNF-alpha in epithelial cell
9) Confidence 0.70 Published 1997 Journal Scand. J. Gastroenterol. Section Body Doc Link 9246701 Disease Relevance 0 Pain Relevance 0
Similarly, intraportal infusion of NE in vivo or in isolated livers increased TNF-alpha synthesis and release which was inhibited by co-infusion of yohimbine.
Positive_regulation (increased) of Gene_expression (synthesis) of TNF-alpha in livers
10) Confidence 0.70 Published 2001 Journal Biochim. Biophys. Acta Section Abstract Doc Link 11476962 Disease Relevance 0.17 Pain Relevance 0.27
The role of Kupffer cell alpha(2)-adrenoceptors in norepinephrine-induced TNF-alpha production.
Positive_regulation (-) of Gene_expression (production) of TNF-alpha in Kupffer cell
11) Confidence 0.70 Published 2001 Journal Biochim. Biophys. Acta Section Title Doc Link 11476962 Disease Relevance 0.46 Pain Relevance 0.18
Moderate and strong cauda equina compression induces TNF-alpha expression and degeneration associated with macrophage invasion.
Positive_regulation (induces) of Gene_expression (expression) of TNF-alpha in macrophage
12) Confidence 0.70 Published 2004 Journal Spine Section Body Doc Link 15131438 Disease Relevance 0 Pain Relevance 0
SUMMARY OF BACKGROUND DATA: Compression of the cauda equina reduces blood flow in compressed nerve roots and causes TNF-alpha expression and neuropathological change.
Positive_regulation (causes) of Gene_expression (expression) of TNF-alpha in nerve
13) Confidence 0.70 Published 2004 Journal Spine Section Body Doc Link 15131438 Disease Relevance 0 Pain Relevance 0
CONCLUSION: Mild cauda equina compression induces TNF-alpha expression and demyelination.
Positive_regulation (induces) of Gene_expression (expression) of TNF-alpha
14) Confidence 0.70 Published 2004 Journal Spine Section Body Doc Link 15131438 Disease Relevance 0 Pain Relevance 0
Elevated expression of TNF-alpha was noted to occur within the first 7 days post-axotomy, which subsequently normalized to baseline levels by day 14.
Positive_regulation (Elevated) of Gene_expression (expression) of TNF-alpha
15) Confidence 0.70 Published 2008 Journal Neurol. Res. Section Body Doc Link 18489817 Disease Relevance 0.31 Pain Relevance 0
Collectively, this evidence suggests that enhanced early neuronal expression of TNF alpha after TBI contributes to subsequent neurological dysfunction.
Positive_regulation (enhanced) of Gene_expression (expression) of TNF alpha in neuronal associated with anesthesia and brain injury
16) Confidence 0.70 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10229121 Disease Relevance 1.11 Pain Relevance 0.26
Similarly, intravenous administration of SNC 80 (6.8 mg/kg) significantly (P < 0.01) increased the production of TNF-alpha and nitric oxide (2- and 1.5-fold increases respectively, compared with saline-injected control) by LPS-stimulated splenic macrophages.
Positive_regulation (increased) of Gene_expression (production) of TNF-alpha in splenic macrophages
17) Confidence 0.69 Published 2001 Journal Life Sci. Section Abstract Doc Link 11400911 Disease Relevance 0.33 Pain Relevance 0.43
We showed that SNC 80 at concentrations of 10(-7) M and 10(-6) M, significantly (P < 0.01) stimulated the in vitro production of tumor necrosis factor-alpha (TNF-alpha) (60-100% increase) and nitric oxide (34-67% increase) by resident and LPS-stimulated peritoneal macrophages.
Positive_regulation (stimulated) of Gene_expression (production) of TNF-alpha in peritoneal macrophages associated with necrosis and cancer
18) Confidence 0.69 Published 2001 Journal Life Sci. Section Abstract Doc Link 11400911 Disease Relevance 0.35 Pain Relevance 0.49
Treatment with metalloprotease inhibitor, Zincov, produced dose-dependent reduction (56.9%) in aspirin-induced increase in the mucosal expression of soluble TNF-alpha, evoked a 62% decrease in the rate of epithelial cell apoptosis, and led to a marked reversal (56.9%) in aspirin-induced delay in ulcer healing.
Positive_regulation (increase) of Gene_expression (expression) of TNF-alpha in epithelial cell associated with aspirin, ulcers and apoptosis
19) Confidence 0.69 Published 2000 Journal IUBMB Life Section Abstract Doc Link 11327313 Disease Relevance 1.14 Pain Relevance 0.41
RESULTS: We found activation of microglia and increased expression of TNF-alpha below the level of the lesion in the lumbar spinal cord after T13 lateral hemisection that correlated with emergence of mechanical allodynia in the hind limbs of rats.
Positive_regulation (increased) of Gene_expression (expression) of TNF-alpha in microglia
20) Confidence 0.69 Published 2006 Journal Ann. Neurol. Section Body Doc Link 16634039 Disease Relevance 0.17 Pain Relevance 0

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