INT50

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2011
Negated 1
Speculated 3
Reported most in Abstract
Documents 87
Total Number 90
Disease Relevance 14.94
Pain Relevance 30.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ren) extracellular space (Ren) extracellular region (Ren)
intracellular (Ren) response to stress (Ren)
Anatomy Link Frequency
kidney 20
blood 19
plasma 18
brain 12
Heart 4
Ren (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 245 100.00 Very High Very High Very High
anesthesia 34 100.00 Very High Very High Very High
bradykinin 9 100.00 Very High Very High Very High
cocaine 65 99.98 Very High Very High Very High
agonist 54 99.98 Very High Very High Very High
Neuropeptide 2 99.48 Very High Very High Very High
antagonist 51 99.44 Very High Very High Very High
Neuronal nitric oxide synthase 2 99.32 Very High Very High Very High
local anesthetic 20 99.30 Very High Very High Very High
tetrodotoxin 1 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 25 100.00 Very High Very High Very High
Stress 9 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 1 99.96 Very High Very High Very High
Bordatella Infection 20 99.86 Very High Very High Very High
Natriuresis 24 99.64 Very High Very High Very High
Hypertension 154 99.60 Very High Very High Very High
Acute Renal Failure 6 99.40 Very High Very High Very High
Body Weight 8 98.98 Very High Very High Very High
Weight Loss 2 98.56 Very High Very High Very High
Hypotension 16 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The marked resistance of recovery animals to a second bout of acute renal failure thus cannot be attributed to impaired renin release or inadequate plasma renin substrate.
Negative_regulation (impaired) of Localization (release) of renin in plasma associated with acute renal failure
1) Confidence 0.59 Published 1978 Journal Nephron Section Abstract Doc Link 745630 Disease Relevance 0.56 Pain Relevance 0.12
Sodium chloride suppression of renin release in the unanesthetized rat.
Negative_regulation (suppression) of Localization (release) of renin
2) Confidence 0.59 Published 1975 Journal Endocrinology Section Title Doc Link 1204570 Disease Relevance 0 Pain Relevance 0.25
These results suggest that the reduction of blood pressure in two-kidney, one-clip hypertensive rats may be due to reduced renin release through the action of clonidine, while in one-kidney, one-clip hypertensive rats the sympathetic nervous activity may play little or no role in the maintenance of high blood pressure.
Negative_regulation (reduced) of Localization (release) of renin in kidney associated with hypertension and clonidine
3) Confidence 0.59 Published 1983 Journal Chest Section Abstract Doc Link 6337027 Disease Relevance 0.62 Pain Relevance 0.30
In contrast, phenylephrine, oxymetazoline and clonidine did not inhibit renin release.
Negative_regulation (inhibit) of Localization (release) of renin associated with clonidine
4) Confidence 0.59 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 41729 Disease Relevance 0 Pain Relevance 0.26
Propranolol impaired most of the anesthesia-induced renin release and impaired aldosterone release with the one agent (urethane) studied.
Negative_regulation (impaired) of Localization (release) of renin associated with anesthesia
5) Confidence 0.59 Published 1975 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 1129282 Disease Relevance 0 Pain Relevance 0.36
Since the vasoconstrictor effect of clonidine is considered to be due to alpha-adrenergic stimulation, this observation is similar to a previous study reporting suppression of renin secretion by vasoconstrictor infusions of catecholamines (Vandongen & Peart, 1974). 5.
Negative_regulation (suppression) of Localization (secretion) of renin associated with catecholamine and clonidine
6) Confidence 0.59 Published 1975 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 1236608 Disease Relevance 0 Pain Relevance 0.55
These studies demonstrate a direct intrarenal inhibitory effect of clonidine on renin secretion.
Negative_regulation (effect) of Localization (secretion) of renin associated with clonidine
7) Confidence 0.59 Published 1975 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 1236608 Disease Relevance 0 Pain Relevance 0.53
The inhibition of renin secretion in the isolated rat kidney by clonidine hydrochloride (Catapres).
Negative_regulation (inhibition) of Localization (secretion) of renin in kidney associated with clonidine
8) Confidence 0.59 Published 1975 Journal Clin. Exp. Pharmacol. Physiol. Section Title Doc Link 1236608 Disease Relevance 0 Pain Relevance 0.54
The alpha-adrenergic blocking drug phentolamine prevented clonidine suppression of renin release in sodium-depleted rats and was partially effective in normal rats.
Negative_regulation (prevented) of Localization (release) of renin associated with clonidine
9) Confidence 0.59 Published 1976 Journal Circ. Res. Section Abstract Doc Link 5201 Disease Relevance 0.17 Pain Relevance 0.74
After ganglionic blockade in sodium-depleted rats, clonidine caused a significantly greater suppression of renin release than did an equipressor dose of methoxamine.
Negative_regulation (suppression) of Localization (release) of renin associated with clonidine
10) Confidence 0.59 Published 1976 Journal Circ. Res. Section Abstract Doc Link 5201 Disease Relevance 0.15 Pain Relevance 0.73
The mechanism by which clonidine suppresses renin release was investigated in conscious rats.
Negative_regulation (suppresses) of Localization (release) of renin associated with clonidine
11) Confidence 0.59 Published 1976 Journal Circ. Res. Section Abstract Doc Link 5201 Disease Relevance 0.09 Pain Relevance 0.30
These data, combined with hemodynamic correlates, suggest that clonidine inhibits renin release by activation of an intrarenal alpha-adrenergic receptor.
Negative_regulation (inhibits) of Localization (release) of renin associated with clonidine
12) Confidence 0.59 Published 1976 Journal Circ. Res. Section Abstract Doc Link 5201 Disease Relevance 0.14 Pain Relevance 0.64
These results indicate a peripheral site of action for suppression of renin release by clonidine.
Negative_regulation (suppression) of Localization (release) of renin associated with clonidine
13) Confidence 0.59 Published 1976 Journal Circ. Res. Section Abstract Doc Link 5201 Disease Relevance 0.16 Pain Relevance 0.67
In addition, clonidine (12.5 and 25 microgram/kg body weight, IP), a central alpha-adrenergic agonist known to inhibit renin release, attenuated drinking during 1, 2 and 3 hours after 5-HTP was administered.
Negative_regulation (inhibit) of Localization (release) of renin in body associated with body weight, agonist and clonidine
14) Confidence 0.59 Published 1981 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 7015366 Disease Relevance 0.51 Pain Relevance 0.26
The data presented in this paper are consistent with the conclusion that clonidine acts at some site in the sympathetic nervous system of sodium-depleted rats to inhibit renal nerve activity with a resultant suppression of renin secretion and a reduction of the angiotensin II-maintained arterial blood pressure.
Negative_regulation (suppression) of Localization (secretion) of renin in blood associated with clonidine
15) Confidence 0.58 Published 1975 Journal Circ. Res. Section Abstract Doc Link 1192571 Disease Relevance 0.38 Pain Relevance 0.48
Renal plasma flow was decreased by cyclohexyladenosine, without a corresponding increase in the arteriorenal venous difference in plasma renin concentrations, and arterial plasma renin concentration decreased in all rats given cyclohexyladenosine, suggesting inhibition of renin secretion.
Negative_regulation (inhibition) of Localization (secretion) of renin in plasma
16) Confidence 0.58 Published 1984 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 6386128 Disease Relevance 0 Pain Relevance 0.07
Pertussis toxin: a) increased significantly basal renin secretion, b) displaced to the left the concentration-response curve for isoproterenol and epinephrine and magnified the response to epinephrine and c) abolished the inhibitory effect of clonidine on renin secretion.
Negative_regulation (abolished) of Localization (secretion) of renin associated with bordatella infection and clonidine
17) Confidence 0.58 Published 1986 Journal Life Sci. Section Abstract Doc Link 3005789 Disease Relevance 0.33 Pain Relevance 0.19
It was observed that isoproterenol and epinephrine stimulated renin secretion and that clonidine decreased both basal and isoproterenol-stimulated renin secretion in the control group.
Negative_regulation (decreased) of Localization (secretion) of renin associated with clonidine
18) Confidence 0.58 Published 1986 Journal Life Sci. Section Abstract Doc Link 3005789 Disease Relevance 0.36 Pain Relevance 0.18
Suppression of bradykinin-induced renin release by indomethacin in anesthetized rats.
Negative_regulation (Suppression) of Localization (release) of renin associated with anesthesia and bradykinin
19) Confidence 0.58 Published 1984 Journal Clin Exp Hypertens A Section Title Doc Link 6430607 Disease Relevance 0 Pain Relevance 0.36
Sulindac and ibuprofen inhibit furosemide-stimulated renin release but not natriuresis in men on a normal sodium diet.
Negative_regulation (inhibit) of Localization (release) of renin associated with natriuresis
20) Confidence 0.58 Published 1985 Journal Nephron Section Title Doc Link 3903529 Disease Relevance 0.36 Pain Relevance 0.15

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