INT50010

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Context Info
Confidence 0.42
First Reported 1995
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.64
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 1
CHR (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 11 99.08 Very High Very High Very High
depression 1 96.80 Very High Very High Very High
Endogenous opioid 1 93.28 High High
opiate 3 81.36 Quite High
Opioid 2 75.28 Quite High
agonist 1 57.20 Quite High
palliative 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 190 100.00 Very High Very High Very High
Renal Cancer 36 99.96 Very High Very High Very High
Cancer 90 98.64 Very High Very High Very High
Depression 1 96.80 Very High Very High Very High
Hepatotoxicity 4 90.76 High High
Cretinism 6 86.32 High High
Adhesions 18 84.80 Quite High
Intellectual Impairment 12 83.08 Quite High
Hyperthyroidism 10 64.36 Quite High
Liver Failure 1 61.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, the results of this study highlight the importance of plasma sulfate level as a key modulator of acetaminophen metabolism and suggest that individuals with reduced NaS1 sulfate transporter function would be more sensitive to hepatotoxic agents.
Negative_regulation (reduced) of sulfate transport in plasma associated with paracetamol
1) Confidence 0.42 Published 2006 Journal Hepatology Section Abstract Doc Link 16729303 Disease Relevance 0.38 Pain Relevance 0.88
We suspect that a greater number of Chr-associated genes would have been selected in their study had there been at least two Chr samples, since a gene altered in expression only in the single Chr, but not in any of the oncocytomas or the CC, would not have been identified by the selection criteria.


Negative_regulation (number) of Chr-associated associated with carcinoma
2) Confidence 0.19 Published 2002 Journal BMC Bioinformatics Section Body Doc Link PMC130042 Disease Relevance 1.65 Pain Relevance 0
The observed decrease in CDH1 (E-cadherin) in CC (p-value = 0.0045) also matched previously published reports, as did the decrease in VIM (vimentin) expression in Chr RCCa [13,16].
Negative_regulation (decrease) of Chr associated with renal cancer and carcinoma
3) Confidence 0.19 Published 2002 Journal BMC Bioinformatics Section Body Doc Link PMC130042 Disease Relevance 1.29 Pain Relevance 0
The very first reference to its derivation from chrétien (“christian”) and its use in the Valais to denote stupid goitrous people comes only in 1754, in the Encyclopédie.
Negative_regulation (derivation) of chr tien
4) Confidence 0.04 Published 2004 Journal Medical History Section Body Doc Link PMC547918 Disease Relevance 0.23 Pain Relevance 0
ChR desensitization is regulated not by one but by several known second messengers and G-proteins.
Negative_regulation (desensitization) of ChR
5) Confidence 0.04 Published 1995 Journal Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. Section Abstract Doc Link 7599972 Disease Relevance 0.10 Pain Relevance 0.53

General Comments

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